Identifying a novel insulin-like hormone in a patient with fulminant type 1 diabetes using protein-protein interaction methods
| Project/Area Number |
21591150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 劇症1型糖尿病 / インスリン様物質 / タンパク質間相互作用分析 / 血清 / タンパク質間相互作用解析 |
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| Research Abstract |
In patients with fulminant diabetes, the blood glucose levels are generally difficult to control because their endogenous insulin secretion are depleted from the onset. A patient with fulminant type 1 diabetes shows excellent glycemic control with small amount of exogenous insulin injection. This rare case leads us to hypothesize that an unknown insulin-like hormone will exist in this patient's blood. To explore this hypothesis, we have performed preliminary experiments of protein-protein interaction using human recombinant insulin receptor, although the results were not expected.
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Report
(4 results)
Research Products
(21 results)
