Identification and characterization of susceptibility genes for type 1 diabetes by using syntenic homology between human and mouse
| Project/Area Number |
21591152
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185)
NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 1型糖尿病 / 劇症1型糖尿病 / 緩徐進行1型糖尿病 / 遺伝子 / HLA / ゲノム / 自己免疫 / モデル動物 / NODマウス / 遣伝子 |
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| Research Abstract |
Susceptibility genes for type 1 diabetes were studied by using syntenic homology between mouse and human. Contribution of HLA to type 1 diabetes was shown to be different among three subtypes of type 1 diabetes : qualitative difference between fulminant and other subtypes, and quantitative difference between slowly progressive and acute-onset. Functional polymorphisms of MafA, an insulin transactivator, were associated with reduced expression of insulin in the thymus and susceptibility to type 1 diabetes both in mice and humans through the reduced expression of insulin in the thymus.
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Report
(4 results)
Research Products
(86 results)
