Elucidation of the role of CITED2 in hepatic glucose production
| Project/Area Number |
21591155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
MATSUMOTO Michihiro 独立行政法人国立国際医療研究センター, 研究所・糖尿病研究センター・分子代謝制御研究部, 部長 (90467663)
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Kenjiro 国立国際医療センター, 研究所・臨床薬理研究部, 室長 (80533736)
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| Research Collaborator |
SAKAI Mashito
TSUJIMURA Tomoko
CAO Yongheng
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CITED2 / 遺伝子転写 / 糖尿病 / インスリン / グルカゴン / 肝糖産生 / ノックアウトマウス |
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| Research Abstract |
We unveiled that CITED2 functions as a transducer of glucagon and insulin signaling in the regulation of PGC-1αactivity that is associated with the transcriptional control of gluconeogenesis and that this function is mediated through the modulation of GCN5-dependent PGC-1αacetylation. We also found that loss of hepatic CITED2 function suppresses gluconeogenesis in diabetic mice, suggesting it as a therapeutic target for hyperglycemia.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation2012
Author(s)
Kimura K, Yamada T, Matsumoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H
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Journal Title
Diabetes
Volume: 61
Pages: 61-73
Related Report
Peer Reviewed
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[Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC12011
Author(s)
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Matsumoto M, Kasuga M, Kido Y
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URL
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Peer Reviewed
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[Journal Article] Overexpression of KLF15 in adipocytes of mice results in down-regulation of SCD1 expression in adipocytes and consequent enhancement of glucose-induced insulin secretion2011
Author(s)
Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M
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Journal Title
J Biol Chem
Volume: 286
Pages: 37458-37469
Related Report
Peer Reviewed
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[Journal Article] Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC12011
Author(s)
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y
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Related Report
Peer Reviewed
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[Presentation] 脂肪細胞における転写因子KLF15の過剰発現はSCD1発現を抑制し、インスリン分泌を増加させる2011
Author(s)
永礼智基, 阪上浩, 松本道宏, 曹永恒, 酒井真志人, 稲垣健二郎, 松木泰, 渡辺英二郎, 池田和貴, 田口良, 上村尚美, 太田成男, 平松隆司, 春日雅人
Organizer
第32回日本肥満学会
Place of Presentation
淡路
Year and Date
2011-09-23
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