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The physiological and pathophysiological role of IRS-1 and IRS-2 in the liver

Research Project

Project/Area Number 21591156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

KUBOTA Tetsuya  独立行政法人国立健康・栄養研究所, 臨床栄養研究部栄養療法研究室, 室長 (60385698)

Co-Investigator(Kenkyū-buntansha) KUBOTA Naoto  東京大学, 医学部, 准教授 (50396719)
KADOWAKI Takashi  東京大学, 医学部, 教授 (30185889)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病 / シグナル伝達 / 遺伝子
Research Abstract

In the liver in type 2 diabetes, PEPCK pathway is resistant to insulin action, leading to hyperglycemia via upregulation of gluconeogenesis. On the other hand, insulin pathway is superactive to upregulate SREBP1c to cause steatosis and hypertriglyceridemia. Why impaired insulin action in glucose metabolism "hyperglycemia"and exaggerated insulin action in lipid metabolism"steatosis, coexist in the liver in type 2 diabetes? To investigate these mechanisms, we fed our LIRS1KO and LIRS2KO mice on a HF diet. IRS1 expression levels on a HF diet did not show any change in the control mice. In contrast, unlike IRS1, IRS2 underwent profound downregulation in the control mice on a HF diet. LIRS1KO mice on a HF diet showed severe glucose intolerance and suppression of hepatic steatosis. In contrast, LIRS2KO mice showed only mild glucose intolerance and hepatic steatosis. Under a HF diet, IRS2 is profoundly downregulated, which is causally involved in the dysregulation of glucose metabolism. On the other hand, hyperinsulinemia-mediated IRS1 signal is rather increased, because IRS1 is not downregulated. So, it is causally involved in the steatosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (87 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (82 results) Book (1 results)

  • [Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, et al
    • Journal Title

      Cell Metab

      Volume: 13 Pages: 294-307

    • URL

      http://dx.doi.org/10.1016/j.cmet.2011.01.018

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 294-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived secretory protein, selenoprotein p, causes insulin resistance2010

    • Author(s)
      Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowai T, et al
    • Journal Title

      Cell Metab

      Volume: 12 Pages: 483-495

    • NAID

      120002661942

    • URL

      http://dx.doi.org/10.1016/j.cmet.2010.09.015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived secretory protein, selenoprotein p, causes insulin resistance.2010

    • Author(s)
      Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S.
    • Journal Title

      Cell Metabolism

      Volume: 12 Pages: 483-495

    • NAID

      120002661942

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] チアゾリジン誘導体はアディポネクチン依存性・非依存性に動脈硬化を抑制する2012

    • Author(s)
      窪田哲也、窪田直人、佐藤寛之、岩村智勝、井上真理子、林高則、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第26回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 中枢のIRS-2は肝臓のインスリン感受性を調節する2012

    • Author(s)
      井上真理子、窪田直人、窪田哲也、熊谷洋紀、河合智子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第26回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS1、IRS2の役割2012

    • Author(s)
      岩村智勝,窪田直人,窪田哲也,井上真理子,佐藤寛之,林高則,高本偉碩,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第15回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-01-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている2011

    • Author(s)
      高本偉碩,窪田直人,中屋恵三,熊谷勝義,小畑淳史,勝山修行,窪田哲也,植木浩二郎,門脇孝
    • Organizer
      第25回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明-脳特異的IRS-2欠損マウスを用いて-2011

    • Author(s)
      井上真理子,窪田直人,窪田哲也,熊谷洋紀,河合智子,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第25回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 肥満・インスリン分泌不全を呈する2型糖尿病モデル動物に対するDPP-4阻害薬の長期投与効果2011

    • Author(s)
      中屋恵三,佐藤寛之,窪田直人,高本偉碩,窪田哲也,勝山修行,橋本信嗣,後藤守兄,城森孝仁,植木浩二郎,門脇孝
    • Organizer
      第25回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨格筋のインスリン感受性調節における血管内皮細胞のインスリンシグナルの役割の解明2011

    • Author(s)
      窪田哲也,窪田直人,熊谷洋紀,井上真理子,河合智子,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第25回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Impaired Insulin Signaling in the Endothelial Cells Reduces Insulin-induced Glucose Uptake by the Skeletal Muscle2011

    • Author(s)
      Tetsuya Kubota, Naoto Kubota, Tomokatsu Iwamura, Mariko Inoue, Hiroyuki Sato, Takanori Hayashi, Iseki Takamoto, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮細胞インスリンシグナル障害はインスリン依存性の骨格筋の糖取り込み障害を惹起する2011

    • Author(s)
      窪田直人,窪田哲也,植木浩二郎,門脇孝
    • Organizer
      第61回日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている2011

    • Author(s)
      高本偉碩,窪田直人,小畑淳史,熊谷勝義,勝山修行,窪田哲也,北村忠弘,植木浩二郎,門脇孝
    • Organizer
      第61回日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明-脳特異的IRS-2欠損マウスを用いて-2011

    • Author(s)
      井上真理子,窪田直人,窪田哲也,岩村智勝,佐藤寛之,林高則,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第61回日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] チアゾリジン誘導体の抗動脈硬化作用におけるアディポネクチンの役割の解明2011

    • Author(s)
      窪田哲也、窪田直人、佐藤寛之、岩村智勝、井上真理子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 視床下部腹内側核(VMH)破壊肥満モデルではアディポネクチン(ADN)産生が充進する2011

    • Author(s)
      鈴木洋子,石塚典子,清水弘行,大坂寿雅,窪田直人,窪田哲也,門脇孝,井上修二
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] インスリン感受性調節におけるインターロイキン33の役割について2011

    • Author(s)
      渡部拓,竹内倫徳,窪田直人,坂上慎二,後藤知紗,辻野一三,窪田哲也,三品昌美,門脇孝,西村正治
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 視床下部腹内側核(VMH)破壊肥満モデルではアディポネクチン(ADN)産生が亢進する2011

    • Author(s)
      鈴木洋子, 石塚典子, 清水弘行, 大坂寿雅, 窪田直人, 窪田哲也, 門脇孝, 井上修二
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impaired insulin signaling in the endothelial cells reduces insulininduced glucose uptake by the skeletal muscle2011

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Hiroki Kumagai, Marika Inoue, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      Scientific Sessions 71th American Diabetes Association
    • Place of Presentation
      San Diego
    • Year and Date
      2011-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle2011

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Hiroki Kumagai, Mariko Inoue, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      Scientific Sessions 71th American Diabetes Association
    • Place of Presentation
      San Diego
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Effects of SK-0403, a highly selective DPP-4 inhibitor, on β-cell mass and function in haploinsufficiency of β-cell-specific glucokinase mice on a high-fat diet2011

    • Author(s)
      Keizo Nakaya, Naoto Kubota, Iseki Takamoto, Tetsuya Kubota, Hisayuki Katsuyama, Hiroyuki Sato, Shinji Hashimoto, Moritaka Goto, Takahito Jomori, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      71th American Diabetes Association's Scientific Sessions
    • Place of Presentation
      San Diego
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] PGI2アナログは血管内皮細胞のインスリンシグナルを介して肥満モデルマウスの骨格筋のインスリン依存性糖取り込みを改善する2011

    • Author(s)
      窪田哲也、窪田直人、岩村智勝、井上真理子、佐藤寛之、高本偉碩、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第29回肥満症治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 血管内皮細胞インスリンシグナル障害はインスリン依存性の骨格筋の糖取り込み障害を惹起する2011

    • Author(s)
      窪田哲也、窪田直人、熊谷洋紀、井上真理子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] プロスタサイクリン誘導体、ベラプロストナトリウムと低用量ピオグリタゾンの併用による糖尿病改善作用の検討2011

    • Author(s)
      熊谷洋紀、高橋雄大、窪田直人、窪田哲也、井上真理子、河合智子、門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS1、IRS2の役割2011

    • Author(s)
      窪田直人,窪田哲也,熊谷洋紀,井上真理子,渡部拓,西村正治,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] インスリン感受性調節におけるインターロイキン33の役割について2011

    • Author(s)
      渡部拓,竹内倫徳,窪田直人,坂上慎二,後藤知紗,窪田哲也,西村正治,三品昌美,門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている2011

    • Author(s)
      高本偉碩,窪田直人,中屋恵三,熊谷勝義,小畑淳史,勝山修行,窪田哲也,北村忠弘,植木浩二郎,門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] DPP-4阻害薬の2型糖尿病モデル動物に対する抗糖尿病作用2011

    • Author(s)
      中屋恵三,窪田直人,高本偉碩,窪田哲也,佐藤寛之,勝山修行,橋本信嗣,後藤守兄,城森孝仁,植木浩二郎,門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明-脳特異的IRS-2欠損マウスを用いて-2011

    • Author(s)
      井上真理子、窪田直人、窪田哲也、熊谷洋紀、河合智子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-1、IRS-2の役割2011

    • Author(s)
      窪田直人,窪田哲也,熊谷洋紀,井上真理子,渡部拓,西村正浩,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明脳特異的IRS-2欠損マウスを用いて2011

    • Author(s)
      井上真理子, 窪田直人, 窪田哲也, 熊谷洋紀, 河合智子, 山内敏正, 植木浩二郎, 門脇孝
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Effects of SK-o4os, a highly selective DPP-4 inhibitor, on(s-cell mass and function in haploinsufficiency of) s-cellspecific glucokinase mice on a high-fat diet2011

    • Author(s)
      Keizo Nakaya, Naoto Kubota, Iseki Takamoto, Tetsuya Kubota, Hisayuki Katsuyama, Hiroyuki Sate, Shinji Hashimoto, Moritaka Goto, Takahito Jomori, Kohjiro Ueki, and Takashi Kadowaki
    • Organizer
      71th American Diabetes Association's Scientific Sessions
    • Place of Presentation
      San diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired Insulin Signaling in the Endothelial Cells Reduces Insulininduced Glucose Uptake by the Skeletal Muscle2011

    • Author(s)
      Tetsuya Kubota, Naoto Kubota, Tomokatsu Iwamura, Marika Inoue, Hiroyuki Sate, Takanori Hayashi, Iseki Takamoto, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle2010

    • Author(s)
      窪田直人、窪田哲也、門脇孝
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮細胞インスリンシグナルの糖代謝調節における役割の解明2010

    • Author(s)
      窪田直人,窪田哲也,門脇孝
    • Organizer
      第60回日本体質医学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] アディポネクチンの摂食・エネルギー代謝調節メカニズム2010

    • Author(s)
      窪田直人, 窪田哲也, 山内敏正, 植木浩二郎, 箕越靖彦, 門脇孝
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-l、IRS-2の役割2010

    • Author(s)
      窪田直人,窪田哲也,渡部拓,西村正治,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨格筋のインスリン感受性調節における血管内皮細胞のインスリンシグナルの役割の解明2010

    • Author(s)
      窪田哲也,窪田直人,熊谷洋紀,井上真理子,河合智子,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-1、 IRS-2の役割2010

    • Author(s)
      窪田直人, 窪田哲也, 渡部拓, 西村正治, 山内敏正, 植木浩二郎, 門脇孝
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肥満・インスリン分泌不全を呈する2型糖尿病モデル動物に対するDPP-4阻害薬の長期投与効果2010

    • Author(s)
      中屋恵三, 窪田直人, 高本偉碩, 窪田哲也, 勝山修行, 橋本信嗣, 後藤守兄, 城森孝仁, 植木浩二郎, 門脇孝
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肥満・インスリン分泌不全を呈する2型糖尿病モデル動物に対するDPP-4阻害薬の長期投与効果2010

    • Author(s)
      中屋恵三, 窪田直人, 高本偉碩, 窪田哲也, 勝山修行, 橋本信嗣, 後藤守兄, 城森孝仁, 植木浩二郎, 門脇孝
    • Organizer
      第3回日本肥満症治療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelial insulin signaling regulates capillary recruitment and glucose uptae in skeleal muse Scientific Sessions2010

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Hiroki Kumagai, Mariko Inoue, Tomoko Kawai, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      70th American Diabetes Association
    • Place of Presentation
      Orlando
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Endothelial insulin signaling regulates capillary recruitment and glucose uptake in skeletal muscle2010

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Hiroki Kumagai, Mariko Inoue, Tomoko Kawai, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      Scientific Sessions 70^<th> American Diabetes Association
    • Place of Presentation
      Orlando
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelial insulin signaling regulates capillary recruitment and glucose uptake in skeletal muscle2010

    • Author(s)
      Tetsuya Kubota, Naoto Kubota, Hiroki Kumagai, Mariko Inoue, Tomoko Kawai, Toshimasa Yamauchi, Kohjiro Ueki 1and Takashi Kadowaki
    • Organizer
      The 2nd Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      Okayama
    • Year and Date
      2010-05-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 糖と脂質代謝における肝IRS1とIRS2の生理学的・病態生理学的役割2010

    • Author(s)
      窪田直人, 窪田哲也, 熊谷裕紀, 井上真理子, 河合智子, 山内敏正, 植木浩二郎, 門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-l、IRS-2の役割2010

    • Author(s)
      窪田直人,窪田哲也,熊谷裕紀,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] チアゾリジン誘導体の抗動脈硬化作用におけるアディポネクチンの役割の解明2010

    • Author(s)
      河合智子,窪田直人,窪田哲也,熊谷洋紀,井上真理子,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 骨格筋のインスリン感受性調節における血管内皮細胞のインスリンシグナルの役割の解明2010

    • Author(s)
      窪田哲也,窪田直人,熊谷洋紀,井上真理子,河合智子,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている2010

    • Author(s)
      高本偉碩, 窪田直人, 中屋恵三, 熊谷勝義, 勝山修行, 窪田哲也, 植木浩二郎, 門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-1、 IRS-2の役割2010

    • Author(s)
      窪田直人, 窪田哲也, 熊谷裕紀, 山内敏正, 植木浩二郎, 門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] DPP-4阻害薬の2型糖尿病モデル動物に対する長期投与効果の検討2010

    • Author(s)
      中屋恵三, 窪田直人, 高本偉碩, 窪田哲也, 勝山修行, 橋本信嗣, 後藤守兄, 城森孝仁, 植木浩二郎, 門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明 脳特異的IRS-2欠損マウスを用いて2010

    • Author(s)
      井上真理子, 窪田直人, 窪田哲也, 熊谷洋紀, 河合智子, 山内敏正, 植木浩二郎, 門脇孝
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelial insulin signaling regulates glucose uptake by skeletal muscle2010

    • Author(s)
      Tetsuya Kubota, 1 Naoto Kubota, 1 Hiroki Kumagai1 Mariko Inoue, 1 Iseki Takamoto, 1 Toshimasa Yamauchi, 1 Kohjiro Ueki, 1 and Takashi Kadowaki
    • Organizer
      The 14th international congress of endocrinology
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管内皮細胞のインスリンシグナルの糖代謝調節における役割の解明2010

    • Author(s)
      窪田哲也、窪田直人、熊谷洋紀、井上真理子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第83回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明脳特異的IRS-2欠損マウスを用いて2010

    • Author(s)
      井上真理子,窪田直人,窪田哲也,熊谷洋紀,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第83回日本内分泌学会術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-1、IRS-2の機能的な役割分担2010

    • Author(s)
      窪田直人,窪田哲也,渡部拓,西村正治,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第83回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明-脳特異的IRS-2欠損マウスを用いて-2010

    • Author(s)
      井上真理子、窪田直人、窪田哲也、熊谷洋紀、山口真一、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第83回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rimonabant Ameliorates Insulin Resistance via both Adiponectin-dependent and Adiponectin-independent Pathways2010

    • Author(s)
      Naoto Kubota, Taku Watanabe, Tetsuya Kubota, Iseki Takamoto, Kohjiro Ueki, and Takashi Kadowaki
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Endothelial insulin-induced eNOS activation regulates capillary ecruitment and glucos uptake in skeletal muscle2010

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Hiroki Kumagai, Toshimasa Yamauchi, Kohjiro Ueki and Takashi Kadowaki
    • Organizer
      8th International Diabetes Federation Western Pacific Region Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] The physiological and pathophysiological roles of Insulin Receptor substrate 1 and 2 in the regulation of glucose and lipid metabolism in the liver2009

    • Author(s)
      Naoto Kubota、Kubota T、Toshimasa Yamauchi、Kohjiro Ueki, Kadowaki T, The 15th Congress of the ASEAN Federation of Endocrine Societies
    • Organizer
      The 15th Congress of the ASEAN Federation of Endocrine Societies
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] The physiological and pathophysiological roles of Insulin Receptor substrate 1 and 2 in the regulation of glucose and lipid metabolism in the liver2009

    • Author(s)
      Naoto Kubota、Kubota T、Toshimasa Yamauchi、Kohjiro Ueki、Kadowaki T
    • Organizer
      The 15th Korea-Japan Symposium on Diabetes Mellitus
    • Place of Presentation
      Jeju Island
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] アディポネクチンの摂食・エネルギー調節における役割2009

    • Author(s)
      窪田直人、窪田哲也、山内敏正、植木浩二郎、箕越靖彦、門脇孝
    • Organizer
      第62回日本自律神経学会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨格筋のインスリン感受性調節における血管内皮細胞のインスリンシグナルの役割の解明2009

    • Author(s)
      窪田哲也、窪田直人、熊谷洋紀、井上真理子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第13回日本心血管内分泌学会
    • Place of Presentation
      大宮
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-1, IRS-2の機能的な役割分担2009

    • Author(s)
      窪田直人,窪田哲也,山内敏正,植木浩二郎,門脇孝
    • Organizer
      第30回日本肥満学会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 食事中の脂肪酸組成が肥満やインスリン感受性・耐糖能に与える影響について2009

    • Author(s)
      内山弓子、門脇弘子、加藤美智子、井上真理子、窪田哲也、窪田直人、門脇孝
    • Organizer
      第30回日本肥満学会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝臓の糖・脂質代謝におけるIRS-1,IRS-2の機能的な役割分担2009

    • Author(s)
      窪田直人、窪田哲也、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第30回日本肥満学会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗肥満薬リモナバンのインスリン抵抗性改善機構について2009

    • Author(s)
      渡部拓、窪田直人、大杉満、窪田哲也、高本偉碩、窪田哲也、山内敏正、寺内康夫、戸辺一之、植木浩二郎、門脇孝
    • Organizer
      第30回日本肥満学会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of adiponectin in the CNS in the regulation of energy homoeostasis2009

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Kohjiro Ueki, Toshimasa Yamauchi, Minokoshi Yasuhiko, Takashi Kadowaki
    • Organizer
      Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Yakushima
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨格筋のインスリン感受性調節における血管内皮細胞のインスリンシグナルの役割の解明2009

    • Author(s)
      窪田哲也
    • Organizer
      第14回アディポサイエンス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管内皮細胞のインスリンシグナルの糖代謝調節における役割の解明2009

    • Author(s)
      窪田哲也、窪田直人、熊谷洋紀、井上真理子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第59回日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-26
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 糖尿病体質とは 糖尿病の分子生物学の最前線 肝臓の糖・脂質代謝におけるIRS-1、IRS-2の機能的な役割分担2009

    • Author(s)
      窪田直人、窪田哲也、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第59回日本体質医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pioglitazone Ameliorates Cuff Induced Neointimal Formation by both Adiponectin Dependent and Independent Pathways2009

    • Author(s)
      Tetsuya Kubota, Naoto Kubota, Iseki Takamoto, Masao Moroi, Kaoru Sugi, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      第41回日本動脈硬化学会年次学術集会
    • Place of Presentation
      山口
    • Year and Date
      2009-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Pioglitazone Ameliorates Cuff Induced Neointimal Formation by both Adiponectin Dependent and Independent Pathways.2009

    • Author(s)
      Tetsuya Kubota、Naoto Kubota、Iseki Takamoto, Masao Moroi, Kaoru Sugi, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      第41回日本動脈硬化学会年次学術集会
    • Place of Presentation
      山口
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管内皮細胞インスリンシグナルの糖代謝調節における役割の解明2009

    • Author(s)
      窪田哲也、窪田直人、山口真一、井上真理子、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 膵β細胞にdominant negative型Tcf7l2を過剰発現させたマウスは耐糖能異常を呈する2009

    • Author(s)
      高本偉碩、窪田直人、中屋恵三、熊谷勝義、勝山修行、渡部拓、窪田哲也、植木浩二郎、宮崎純一、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管内皮特異的Akt/PKB欠損マウスの解析2009

    • Author(s)
      鈴木美穂、植木浩二郎、金子和真、窪田哲也、窪田直人、Morris Birnbaum、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明-脳特異的IRS-2欠損マウスを用いて2009

    • Author(s)
      井上真理子、窪田直人、窪田哲也、山口真一、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗肥満薬リモナバンのインスリン抵抗性改善機構にはアディポネクチンに依存的なパスウェイと非依存的なパスウェイがある2009

    • Author(s)
      渡部拓、窪田直人、窪田哲也、大杉満、高本偉碩、山内敏正、寺内康夫、戸辺一之、植木浩二郎、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] IRS-2欠損膵β細胞株の樹立2009

    • Author(s)
      中屋恵三、高本偉碩、窪田直人、熊谷勝義、勝山修行、渡部拓、窪田哲也、植木浩二郎、宮崎純一、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵β細胞にdominant negative型Tcf712を過剰発現させたマウスは耐糖能異常を呈する2009

    • Author(s)
      高本偉碩、窪田直人、中屋恵三、熊谷勝義、勝山修行、渡部拓、窪田哲也、植木浩二郎、宮崎純一、門脇孝
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] インスリンシグナルの破綻と糖尿病 肝臓の糖・脂質代謝におけるIRS-1、IRS-2の役割2009

    • Author(s)
      窪田直人、窪田哲也、伊藤晋介、山内敏正、寺内康夫、戸辺一之、植木浩二郎、門脇孝
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢のIRS-2の糖代謝調節における役割の解明-脳特異的IRS-2欠損マウスを用いて2009

    • Author(s)
      井上真理子、窪田直人、窪田哲也、山口真一、山内敏正、植木浩二郎、門脇孝
    • Organizer
      第46回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of adiponectin in the CNS in the regulation of energy homoeostasisi2009

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Kohjiro Ueki, Toshimasa Yamauchi, Minokoshi Yasuhiko, Takashi Kadowaki
    • Organizer
      Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Yakushima
    • Related Report
      2011 Final Research Report
  • [Presentation] The physiological and pathophysiological roles of Insulin Receptor substrate 1and 2 in the regulation of glucose and lipid metabolism in the liver2009

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      The 15th Korea-Japan Symposium on Diabetes Mellitus
    • Place of Presentation
      Jeju Island
    • Related Report
      2011 Final Research Report
  • [Presentation] The physiological and pathophysiological role ofInsulin Receptor substrate 1 and 2 in the regulation of glucose and lipid metabolism in the liver2009

    • Author(s)
      Naoto Kubota, Tetsuya Kubota, Toshimasa Yamauchi, Kohjiro Ueki, Takashi Kadowaki
    • Organizer
      The 15th Congress of the ASEAN Federation of Endocrine Societies
    • Place of Presentation
      Bangkok
    • Related Report
      2011 Final Research Report
  • [Book] 栄養・食生活、「健康食品」と生活習慣病-C.糖尿病,健康・栄養食品アドバイザリースタッフ・テキストブック2010

    • Author(s)
      窪田哲也
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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