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Involvement of ABCA1 transporter in the regulation of anti-atherogenic sphingosine-1-phosphate content in plasma and high-density lipoprotein

Research Project

Project/Area Number 21591158
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionGunma University

Principal Investigator

SATO Koichi  群馬大学, 生体調節研究所, 准教授 (00302498)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsABCA1トランスポ.タ. / スフィンゴシン1-リン酸 / リポ蛋白質 / スフィンゴシン / HDL / 抗動脈硬化性脂質 / ApoA-I / スフィンゴシンキナーゼ / ABCA1トランスポーター / ApoAI / スフンゴシン1-リン酸
Research Abstract

Sphingosine 1-phosphate (S1P) is accumulated in plasma high-density lipoprotein (HDL), which induces anti-atherogenic actions in endothelial and smooth muscle cells. However, it remains uncharacterized how extracellular S1P is produced and accumulated in HDL particles. This study has focused on the relationship between S1P accumulation in HDL particles and lipoprotein formation by ATP-binding cassette transporter A1 (ABCA1 transporter). Our results using ABCA1 transporter-deficient and lecithin-cholesterol acyltransferase-deficient mice suggested that ABCA1 transporter may be involved in the accumulation of S1P in HDL particles.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (55 results)

All 2012 2011 2010 2009 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (17 results) Remarks (8 results)

  • [Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo2012

    • Author(s)
      Mayumi Komachi, Koichi Sato, Masayuki Tobo, Chihiro Mogi, Takayuki Yamada, Hideo Ohta, Hideaki Tomura, Takao Kimura, Dong-Soon Im, Keisuke Yanagida, Satoshi Ishii, Izumi Takeyoshi, Fumikazu Okajima
    • Journal Title

      Cancer Sci

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates panereatic cancer invasion and metastasis in vivo2012

    • Author(s)
      Komachi M
    • Journal Title

      Cancer Science

      Volume: (印刷中) Issue: 6 Pages: 1099-1104

    • DOI

      10.1111/j.1349-7006.2012.02246.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages2011

    • Author(s)
      Xiao-Dong He, Masayuki Tobo, Chihiro Mogi, Takashi Nakakura, Mayumi Komachi, Naoya Murata, Mutsumi Takano, Hideaki Tomura, Koichi Sato, Fumikazu Okajima
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: Vol.415 Pages: 627-631

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages, Biochem2011

    • Author(s)
      Shinichi Matsuzaki, Tamotsu Ishizuka, Hidenori Yamada, Yosuke Kamide, Takeshi Hisada, Isao Ichimonji, Haruka Aoki, Masakiyo Yatomi, Mayumi Komachi, Hiroaki Tsurumaki, Akihiro Ono, Yasuhiko Koga, Kunio Dobashi, Chihiro Mogi, Koichi Sato, Hideaki Tomura, Masatomo Mori, Fumikazu Okajim, Fumikazu Okajim
    • Journal Title

      Biophys. Res. Commun

      Volume: Vol.413 Pages: 499-503

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes2011

    • Author(s)
      Koichi Sato, Yuta Horiuchi, Ye Jin, Enkhzol Malchinkhuu, Mayumi Komachi, Toshihiko Kondo, Fumikazu Okajim
    • Journal Title

      J. Neurochem

      Volume: Vol.117 Pages: 164-174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages2011

    • Author(s)
      Xiao-Dong He
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 415 Issue: 4 Pages: 627

    • DOI

      10.1016/j.bbrc.2011.10.122

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth musele cells2011

    • Author(s)
      Matsuzaki S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413 Issue: 4 Pages: 499-503

    • DOI

      10.1016/j.bbrc.2011.08.087

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unmasking of LPA(1)receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes2011

    • Author(s)
      Sato K
    • Journal Title

      J Neurochem

      Volume: 117 Issue: 1 Pages: 164-174

    • DOI

      10.1111/j.1471-4159.2011.07188.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unmasking of LPA_1 receptor-mediated migration response to lysophosphatidic acid by interleulcin-1β-induced attenuation of Rho signaling pathways in rat astrocytes.2011

    • Author(s)
      Koichi Sato
    • Journal Title

      J.Neurochem.

      Volume: 117(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein2010

    • Author(s)
      Koichi Sato, Fumikazu Okajima
    • Journal Title

      World J. Biol. Chem

      Volume: Vol.1 Pages: 327-337

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification simulates IL-6 production and Ca2^+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells2010

    • Author(s)
      Isao Ichimonji, Hideaki Tomura, Chihiro Mogi, Koichi Sato, Haruka Aoki, Takeshi Hisada, Kunio Dobashi, Tamotsu Ishizuka, Masatomo Mori, Fumikazu Okajima
    • Journal Title

      Am. J. Physiol. Lung Cell. Mol. Physiol

      Volume: Vol.299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways2010

    • Author(s)
      Jin-Peng Liu, Mayumi Komachi, Hideaki Tomura, Chihiro Mogi, Alatangaole Damirin, Masayuki Tobo, Mutsumi Takano, Hiromi Nochi, Koichi Tamoto, Koichi Sato, Fumikazu Okajima
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol

      Volume: Vol.299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways2010

    • Author(s)
      Jin-Peng Liu, Takashi Nakakura, Hideaki Tomura, Masayuki Tobo, Chihiro Mogi, Ju-Qiang Wang, Xiao-Dong He, Mutsumi Takano, Alatangaole Damirin, Mayumi Komachi, Koichi Sato, Fumikazu Okajima
    • Journal Title

      Pharmacol. Res

      Volume: Vol.61 Pages: 499-505

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞外pH環境を感知するプロトン感受性GPCRの機能と作用機構2010

    • Author(s)
      戸村秀明, 茂木千尋, 佐藤幸市, 岡島史和
    • Journal Title

      日薬理誌

      Volume: Vol.135 Pages: 240-244

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of sphingosine 1-phosphate in anti-atherogenic actions of hig h-density lipoprotein.2010

    • Author(s)
      Koichi Sato
    • Journal Title

      World J.Biol.Chem.

      Volume: 1 Pages: 327-331

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification simulates IL-6 production and Ca^<2+> mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells.2010

    • Author(s)
      Isao Ichimonji
    • Journal Title

      Am.J.Physiol.Lung Cell.Mol.Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells.2010

    • Author(s)
      Jin-Peng Liu
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.2010

    • Author(s)
      Jin-Peng Liu
    • Journal Title

      Pharmacol.Res.

      Volume: 61 Pages: 499-505

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞外pH環境を感知するプロトン感受性GPCRの機能と作用機機2010

    • Author(s)
      戸村秀明
    • Journal Title

      日薬理誌

      Volume: 135 Pages: 240-244

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010

    • Author(s)
      Takao Kimura
    • Journal Title

      J.Biol.Chem. 285

      Pages: 4387-4397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells2009

    • Author(s)
      Enkhzol Malchinkhuu, Koichi Sato, Tomohiko Maehama, Shogo Ishiuchi, Yuhei Yoshimoto, Chihiro Mogi, Takao Kimura, Hitoshi Kurose, Hideaki Tomura, Fumikazu Okajima
    • Journal Title

      Mol. Biol. Cell

      Volume: Vol.20 Pages: 5156-5165

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells2009

    • Author(s)
      Mayumi Komachi, Alatangaole Damirin, Enkhzol Malchinkhuu, Chihiro Mogi, Masayuki Tobo, Hideo Ohta, Koichi Sato, Hideaki Tomura, Fumikazu Okajima
    • Journal Title

      Vascul. Pharmacol

      Volume: Vol.50 Pages: 178-184

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of superoxide anion production by extracellular acidification in neutrophils2009

    • Author(s)
      Naoya Murata, Chihiro Mogia, Masayuki Tobo, Takashi Nakakura, Koichi Sato, Hideaki Tomura, Fumikazu Okajim
    • Journal Title

      Cell. Immunol

      Volume: Vol.259 Pages: 21-26

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I2009

    • Author(s)
      Fumikazu Okajima, Koichi Sato, Takao Kimura
    • Journal Title

      Endocrine J

      Volume: Vol.56 Pages: 315-332

    • NAID

      10026913244

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] リポタンパク質作用におけるS1Pの役割とそのシグナル伝達機構2009

    • Author(s)
      岡島史和, 木村孝穂, 佐藤幸市
    • Journal Title

      生化学

      Volume: Vol.81 Pages: 393-397

    • NAID

      10024916724

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells.2009

    • Author(s)
      Enkhzol Malchinkhuu
    • Journal Title

      Mol.Biol. Cell 20

      Pages: 5156-5165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells.2009

    • Author(s)
      Mayumi Komachi
    • Journal Title

      Cascul. Pharmacol. 50

      Pages: 178-184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of superoxide anion production by extracellular acidification in neutrophils.2009

    • Author(s)
      Naoya Murata
    • Journal Title

      Cell. Immunol. 259

      Pages: 21-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor calss B type I.2009

    • Author(s)
      Fumikazu Okajima
    • Journal Title

      Endocrine J. 56

      Pages: 315-332

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リポタンパク質作用におけるS1Pの役割とそのシグナル伝達機構2009

    • Author(s)
      岡鳥史和
    • Journal Title

      生化学 81

      Pages: 393-397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血漿ならびにリポ蛋白質HDL中スフィンゴシン1-リン酸量の調節におけるABCA1トランスポーターの役割2011

    • Author(s)
      佐藤幸市, 茂木千尋, 岡島史和
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒト膵臓がん細胞株のインビボ浸潤・転移に対するリゾホスファチジン酸受容体アンタゴニストKi16198の経口投与による抑制作用2011

    • Author(s)
      小町麻由美, 佐藤幸市, 戸村秀明, 岡島史和
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      ホテル東京ガーデンパレス(東京都)
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ヒト膵臓癌細胞株のインビボ転移・浸潤に対するリゾホスファチジン酸受容体アンタゴニストKi16198の抑制作用2010

    • Author(s)
      小町麻由美, 佐藤幸市, 茂木千尋, 当房雅之, 山田敬之, 戸村秀明, 岡島史和
    • Organizer
      BMB2010(日本分子生物学会年会、日本生化学会)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖質コルチコイドの抗炎症作用におけるTDAG8の役割2010

    • Author(s)
      Xiao-Dong He, 当房雅之, 茂木千尋, 佐藤幸市, 戸村秀明、岡島史和
    • Organizer
      BMB2010(日本分子生物学会年会、日本生化学会)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Final Research Report
  • [Presentation] Each one of specified histidine residues in GPR4 is important for acidic pH-induced stimulation of multiple signaling pathways2010

    • Author(s)
      Hideaki Tomura, Jin-Peng Liu, Takashi Nakakura, Masayuki Tobo, Chihiro Mogi, Xiao-Dong He, Mutsumi Takano, Mayumi Komichi, Masashi Ebara, Ayaka Matsui, Koichi Sato, Fumikazu Okajima
    • Organizer
      BMB2010(日本分子生物学会年会、日本生化学会)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Final Research Report
  • [Presentation] β-adrenergic agonist, isoproterenol, inhibits lysophosphatidic acid-induced glioma cell migration through the cAMP/Epac/Rap1B/PTEN-dependent signaling pathways2010

    • Author(s)
      Koichi Sato, Enkhzol Malchinkhuu, Fumikazu Okajima
    • Organizer
      JSH International Symposium in Akita
    • Place of Presentation
      秋田大学(秋田県)
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 細胞外プロトンをセンスするGタンパク共役型受容体の情報変換機構と生体機能2010

    • Author(s)
      戸村秀明, 茂木千尋, 当房雅之, 佐藤幸市, 岡島史和
    • Organizer
      第52回日本脂質生化学会
    • Place of Presentation
      森秋旅館(群馬県)
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ヒト膵臓癌細胞株のインビボ転移・浸潤に対するリゾホスファチジン酸受容体アンタゴニストKi16425の抑制作用2010

    • Author(s)
      小町麻由美
    • Organizer
      BMB2010(日本分子生物学会年会、日本生化学会)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖質コルチコイドの抗炎症作用におけるTDAG8の役割2010

    • Author(s)
      Xiaodong He
    • Organizer
      BMB2010(日本分子生物学会年会、日本生化学会)
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Each one of specified histidine residues in GPR4 is important for acidic pH-induced stimulation of multiple signaling pathways.2010

    • Author(s)
      Hideaki Tomura
    • Organizer
      BMB2010(日本分子生物学会年会、日本生化学会)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] リゾホスファチジン酸による血管内皮細胞のVEカドヘリンのトランスロケーション制御機構2010

    • Author(s)
      木村孝穂
    • Organizer
      第52回日本脂質生化学会
    • Place of Presentation
      森秋旅館(群馬県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットアストロサイトにおけるインターロイキンー1βによるリゾホスファチジン酸受容体/遊走応答系の特異的な増強作用とRhoシグナリング2009

    • Author(s)
      佐藤幸市, 堀内雄太, 小町麻由美, 岡島史和
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト膵臓癌細胞の遊走・浸潤におけるリゾホスファチジン酸受容体LPA2の役割について2009

    • Author(s)
      小町麻由美, 佐藤幸市, 戸村秀明, 岡島史和
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト大動脈平滑筋細胞における細胞外プロトン/OGR1受容体を介したシクロゲナーゼ.2の発現のリゾホスファチジン酸による増加2009

    • Author(s)
      戸村秀明, 劉進朋, 茂木千尋, 小町麻由美, 当房雅之, 中倉敬, 佐藤幸市, 岡島史和
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト大動脈血管平滑筋細胞のCOX-2発現/プロスタサイクリン産生応答におけるプロトン感受性GPCRとLPA受容体のクロストーク2009

    • Author(s)
      劉進朋, 戸村秀明, 茂木千尋, 小町麻由美, 当房雅之, 佐藤幸市, 岡島史和
    • Organizer
      第51回日本脂質生化学会
    • Place of Presentation
      ウィルあいち(愛知県)
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ラットアストロサイトにおけるインターロイキンー1βによるリゾホスファチジン酸受容体/遊走応答系の特異のな増強作用とRhoシグナリング2009

    • Author(s)
      佐藤幸市
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト大動脈平滑筋細胞における細胞外プロトン/OGR1受容体を介したシクロゲナーゼ-2の発現のリゾホスファチジン酸による増加2009

    • Author(s)
      戸村秀明
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.gunma-u.ac.jp/index-j.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.gunma-u.ac.jp/index-j.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.gunma-u.ac.jp/index-j.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.gunma-u.ac.jp/index-j.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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