| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Sphingosine 1-phosphate (S1P) is accumulated in plasma high-density lipoprotein (HDL), which induces anti-atherogenic actions in endothelial and smooth muscle cells. However, it remains uncharacterized how extracellular S1P is produced and accumulated in HDL particles. This study has focused on the relationship between S1P accumulation in HDL particles and lipoprotein formation by ATP-binding cassette transporter A1 (ABCA1 transporter). Our results using ABCA1 transporter-deficient and lecithin-cholesterol acyltransferase-deficient mice suggested that ABCA1 transporter may be involved in the accumulation of S1P in HDL particles.
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