Oxidative stress and phospholipid oxidation : mechanism for the facilitation of monocyte/macrophage adhesion
Project/Area Number |
21591165
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Nippon Medical School |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | リン脂質 / 酸化 / 単球 / 接着 / 脂質代謝異常 / 酸化変性 / PCOOH / ICAM-1 / Rac / マクロファージ / Rac1 |
Research Abstract |
In this study, we investigated the mechanism underlying the induction of THP-1 monocytic cell adhesion to ICAM-1 by phosphatidylcholine hydroperoxide(PCOOH), a primary oxidation product of phosphatidylcholine. Our results indicate that PCOOH may induce the cell adhesion via Rac activation, actin polymerization, and localization of LFA-1.We also found that non-oxidized phosphatidylserine induces THP-1 cell adhesion to ICAM-1 as well as PCOOH.
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Report
(4 results)
Research Products
(17 results)
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[Presentation] Involvement of Rho family proteins on phosphatidylcholine hydroperoxide-induced polymerization and cell adhesion in THP-1 cells2009
Author(s)
A. Asai, F. Okajima, K. Tanimura, Y. Nakajima, M. Nagao, M. Sudo, T. Harada, K. Nakagawa, T. Miyazawa, S. Oikawa
Organizer
8th International Congress of Coronary Artery Disease
Place of Presentation
Prague, Czech Republic
Year and Date
2009-10-13
Related Report
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