Research of SDHB as Malignant marker and oncogenesis in malignant pheochromocytomas
| Project/Area Number |
21591168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMANO Hitoshi 筑波大学, 医療医学系, 教授 (20251241)
ISHII Kiyoaki 筑波大学, 医療医学系, 助教 (80419150)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 悪性褐色細胞腫 / SDHB / TMEM127 / 褐色細胞腫 / 遺伝子診断 / mTOR / MAX / SDHD / 大欠失 / MLPA / PC12 |
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| Research Abstract |
In Japanese malignant pheochromocytoma patients, we detected SDHB mutation in 10 cases, including large deletion. Also, we detected germline TMEM127 mutation (c.116_119delTGTC, p.Ile41ArgfsX39) associated with 2q deletion loss of heterozygosity with bilateral adrenal pheochromocytoma. We have, for the first time, introduced the hypothesis that the antitumor effect of sunitinib observed in malignant pheochromocytomas seems to be associated with direct effects on tumor cells.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Identical germlinemutations in the TMEM127 gene in 2unrelated Japanese patients withbilateral pheochromocytoma2012
Author(s)
Takeichi N, Midorikawa S, Watanabe A, Naing BT, Tamura H, Kano T, Sugihara H, Nissato S, Saito Y, Aita Y, Ishii KA, Igarashi T, Kawakami Y, Hara H, Ikeda T, Shimizu K, Suzuki S, Shimano H, KawamotoM, Shimada T, Watanabe T, Oikawa S, Takekoshi K.
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Journal Title
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Peer Reviewed
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[Presentation] Effects of Sunitinib on Catecholamine Synthesis, Secretion and Apoptosis in Pheochromocytoma PC12 Cells2011
Author(s)
Takekoshi K, Saito Y, Tanaka Y, AitaY, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H
Organizer
Third International Symposium on PHEOCHROMOCYTOMA(Paris, France)
Year and Date
2011-09-16
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