Translational research for novel therapeutic strategy for skeletal dysplasias

• Project/Area Number: 21591176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyoto University
• Principal Investigator: YASODA Akihiro 京都大学, 医学研究科, 講師 (50378642)
• Co-Investigator(Renkei-kenkyūsha): TSUJI Takeito 岡山大学, 自然科学研究科, 准教授 (90314682)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: CNP/GC-B系 / 骨系統疾患 / C型ナトリウム利尿ペプチド(CNP) / モデルマウス / 内軟骨性骨化 / CNP / 軟骨細胞 / BMP

Research Abstract

We performed the translational research of the CNP/GC-B system for impaired skeletal growth of skeletal dysplasias using mice model of skeletal dysplasias. We studied interactions between the CNP/GC-B system and molecules that play essential roles on endochondral bone growth using cell lines and organ culture system. Further we investigated the effects of the CNP GC-B system on impaired bone growth in mice models of skeletal dysplasias.

Research Products

• [Journal Article] Skeletal analysis of the long bone abnormality (lbab/lbab) mouse, a novel chondrodysplastic C-type natriuretic peptide mutant (2012)
  • Author(s): Kondo E, Nakao K, et al
  • Journal Title: Calcif Tissue Int. Volume: 90 Issue: 4 Pages: 307-318
  • DOI: 10.1007/s00223-011-9567-0
  • NAID: 120004057182
  • Peer Reviewed
• [Journal Article] Skeletal Analysis of the Long Bone Abnormality (lbab/lbab)Mouse, A Novel Chondrodysplastic C-Type Natriuretic Peptide Mutant (2012)
  • Author(s): Kondo E, Yasoda A, et al
  • Journal Title: Calcif Tissue Int Volume: 90 Pages: 307-18
  • NAID: 120004057182
  • Peer Reviewed
• [Journal Article] Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias (2010)
  • Author(s): Yasoda A, Nakao K
  • Journal Title: Endocrine Journal Volume: 57 Issue: 8 Pages: 659-666
  • DOI: 10.1507/endocrj.K10E-164
  • NAID: 130004443630
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Circulating C-type natriuretic peptide(CNP) rescues chondrodysplastic CNPknockout mice from their impaired skeletal growth and early death (2010)
  • Author(s): Fujii T, Komatsu Y, Yasoda A, et al.
  • Journal Title: Endocrinology Volume: 151 Issue: 9 Pages: 4381-8
  • DOI: 10.1210/en.2010-0078
  • Peer Reviewed
• [Journal Article] Genetic basis for skeletal disease CNP therapy forachondroplasia (2010)
  • Author(s): Yasoda A, Nakao K
  • Journal Title: Clin Calcium Volume: 20 Pages: 1212-8
• [Journal Article] Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias. (2010)
  • Author(s): Yasoda A, Nakao K
  • Journal Title: Endocr J. Volume: 57 Pages: 659-666
  • NAID: 10029585746
• [Journal Article] Circulating C-type natriuretic peptide (CNP) rescues chondrodysplastic CNP knockout mice from their impaired skeletal growth and early death. (2010)
  • Author(s): Fujii T, Komatsu Y, Yasoda A, et al.
  • Journal Title: Endocrinology Volume: 151 Pages: 4381-4388
  • Peer Reviewed
• [Journal Article] Genetic basis for skeletal disease. CNP therapy for achondroplasia. (2010)
  • Author(s): Yasoda A, Nakao K.
  • Journal Title: Clin Calcium Volume: 20 Pages: 1212-1218
• [Journal Article] Systemic administration of C-typenatriuretic peptide as a novel therapeutic strategy for skeletal dysplasias (2009)
  • Author(s): Yasoda A, Kitamura H, Fujii T, et al.
  • Journal Title: Endocrinology Volume: 150 Issue: 7 Pages: 3138-44
  • DOI: 10.1210/en.2008-1676
  • Peer Reviewed
• [Journal Article] Translational research of novel hormones : lessons from animal models and rare human diseases for common human diseases (2009)
  • Author(s): K. Nakao, K. Ebihara(5人中3番目)
  • Journal Title: J Mol Med Volume: 87 Issue: 10 Pages: 1029-1039
  • DOI: 10.1007/s00109-009-0515-7
  • Peer Reviewed
• [Journal Article] Chronically elevated plasma C-typen atriuretic peptide level stimulates skeletal growth in transgenic mice. Am J Physiol Endocrinol Metab (2009)
  • Author(s): Kake T, Kitamura H, Adachi Y, Yoshioka T, Watanabe T, Matsushita H, Fujii T, Kondo E, Tachibe T, Kawase Y, Jishage K, Yasoda A, et al.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 297 Issue: 6 Pages: E1339-E1348
  • DOI: 10.1152/ajpendo.00272.2009
  • Peer Reviewed
• [Journal Article] Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias. (2009)
  • Author(s): Yasoda, et al.
  • Journal Title: Endocrinology. 150 Pages: 3138-3144
  • Peer Reviewed
• [Journal Article] Translational research of novel hormones : lessons from animal models and rare human diseases for common human diseases. (2009)
  • Author(s): Nakao, et al.
  • Journal Title: J Mol Med. 87 Pages: 1029-1039
  • Peer Reviewed
• [Journal Article] Chronically elevated plasma C-type natriuretic peptide (CNP) level stimulates skeletal growth in transgenic mice. (2009)
  • Author(s): Kake, et al.
  • Journal Title: Am J Physiol Endocrinol Metab. 297
  • Peer Reviewed
• [Presentation] 骨系統疾患に焦点をあてた骨代謝研究 (2011)
  • Author(s): 八十田明宏
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 軟骨無形成症モデルマウスに対するCNP投与による骨伸長障害改善効果の検討 (2010)
  • Author(s): 八十田明宏, 他
  • Organizer: 第28回骨代謝学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-22
• [Presentation] Genetic basis for skeletal disease. CNP therapy for achondroplasia (2010)
  • Author(s): Akihiro Yasoda, et al
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Evaluation forthe role of serum c-type natriureticpeptide in endochondral ossification (2010)
  • Author(s): Toshihito Fujii, Yasato Komatsu, Akihiro Yasoda, et al
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] CNP Therapy (2010)
  • Author(s): Yasoda, et al.
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-30
• [Presentation] Evaluation for the role of serum c-type natriuretic peptide in endochondral ossification (2010)
  • Author(s): Fujii, Yasoda, et al.
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-30
• [Presentation] CNPmutant Lbab mouse as a novel model for skeletal dysplasia (2010)
  • Author(s): Eri Kondo, Akihiro Yasoda, et al
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-29
• [Presentation] CNP mutant Lbab mouse as a novel model (2010)
  • Author(s): Kondo,Yasoda, et al.
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-29
• [Presentation] C型ナトリウム利尿ペプチド(CNP)/グアニル酸シクラーゼB(GC-B)系の骨伸長促進作用とそのトランスレーショナル研究 (2010)
  • Author(s): 八十田明宏他
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-26
• [Presentation] 内軟骨性骨化におけるCNP/GC-B系とTGFβ/BMPファミリーのクロストーク (2010)
  • Author(s): 藤井寿人、八十田明宏、他
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-26
• [Presentation] 著明な高Ca血症で発症し部位同定に難渋した原発性副甲状腺機能亢進症の一例 (2010)
  • Author(s): 近藤絵里、八十田明宏、他
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-26
• [Presentation] 内軟骨性骨化におけるCNP/GC-B系とTGF-B/BMPファミリーのクロストーク (2010)
  • Author(s): 藤井寿人、八十田明宏, 他
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-26
• [Presentation] 著明な高Ca血症で発症し部位同定に難渋した原発性副甲状腺機能亢進症の一例 (2010)
  • Author(s): 近藤絵里、八十田明宏, 他
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-26
• [Presentation] C型ナトリウム利尿ペプチド(CNP)/グアニル酸シクラーゼ-B(GC-B)系の骨伸長促進作用とそのトランスレーショナル研究 (2010)
  • Author(s): 八十田明宏, 他
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-25