Translational research for novel therapeutic strategy for skeletal dysplasias
Project/Area Number |
21591176
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
|
Research Institution | Kyoto University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
TSUJI Takeito 岡山大学, 自然科学研究科, 准教授 (90314682)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | CNP/GC-B系 / 骨系統疾患 / C型ナトリウム利尿ペプチド(CNP) / モデルマウス / 内軟骨性骨化 / CNP / 軟骨細胞 / BMP |
Research Abstract |
We performed the translational research of the CNP/GC-B system for impaired skeletal growth of skeletal dysplasias using mice model of skeletal dysplasias. We studied interactions between the CNP/GC-B system and molecules that play essential roles on endochondral bone growth using cell lines and organ culture system. Further we investigated the effects of the CNP GC-B system on impaired bone growth in mice models of skeletal dysplasias.
|
Report
(4 results)
Research Products
(28 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Chronically elevated plasma C-typen atriuretic peptide level stimulates skeletal growth in transgenic mice. Am J Physiol Endocrinol Metab2009
Author(s)
Kake T, Kitamura H, Adachi Y, Yoshioka T, Watanabe T, Matsushita H, Fujii T, Kondo E, Tachibe T, Kawase Y, Jishage K, Yasoda A, et al.
-
Journal Title
Am J Physiol Endocrinol Metab
Volume: 297
Issue: 6
Pages: E1339-E1348
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-