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Impact of visceral fat and adiponectin on association between sleep apnea and cardiovascular diseases

Research Project

Project/Area Number 21591177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionOsaka University

Principal Investigator

KISHIDA Ken  大阪大学, 医学系研究科, 寄附講座助教 (10437329)

Co-Investigator(Kenkyū-buntansha) FUNAHASHI Tohru  大阪大学, 医学系研究科, 寄附講座教授 (60243234)
KIHARA Shinji  大阪大学, 医学系研究科, 講師 (20332736)
Co-Investigator(Renkei-kenkyūsha) YOSHIDA Ryoko  よしだ睡眠呼吸クリニック, 院長
YOKOI Hiroyoshi  小倉記念病院, 循環器科, 部長
YANAGI Koji  大阪中央病院, 循環器科, 部長
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords内分泌学 / 医療・福祉 / 循環器・高血圧 / 糖尿病 / メタボリックシンドローム
Research Abstract

The study demonstrated that 1) co-existence of sleep-disordered breathing/ sleep apnea and visceral fat accumulation is important of preventing cardiovascular diseases, and 2) dysregulation of adipocytokines and increased oxidative stress are important factors as these molecular mechanisms.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (58 results)

All 2012 2011 2010 2009 Other

All Journal Article (33 results) (of which Peer Reviewed: 23 results) Presentation (24 results) Book (1 results)

  • [Journal Article] Coexistence of visceral fat accumulation and sleep-disordered breathing correlates with coronary artery disease2012

    • Author(s)
      Nakagawa Y, Kishida K, Funahashi T, Yanagi K, Shimomura I
    • Journal Title

      JAT

      Volume: (In press)

    • NAID

      130004444634

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing2012

    • Author(s)
      Nakanishi-Minami T, Kishida K, Nakagawa Y, Nishio M, Nakagawa C, Nishida Y, Yanagi K, Yoshida R, Funahashi T, Shimomura I.
    • Journal Title

      Diabetol Metab Syndr

      Volume: 4 Pages: 6-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical importance of assessment of type 2 diabetes mellitus with visceral obesity. A Japanese perspective2012

    • Author(s)
      Kishida K, Funahashi T, Shimomura I.
    • Journal Title

      Curr Diabetes Rev

      Volume: 8(2) Pages: 84-91

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of sleep-disordered breathing in Japanese patients with acromegaly2012

    • Author(s)
      Kashine S, Kishida K, Funahashi T, Shimomura I.
    • Journal Title

      Endocr J

      Volume: 59(1) Pages: 31-8

    • NAID

      10030392820

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] I.虚血性心疾患A.急性冠症候群11. ACS発症に睡眠障害が関与しているか?2012

    • Author(s)
      岸田, 船橋徹
    • Journal Title

      「EBM循環器疾患の治療2012-2013」中外医学社

      Pages: 50-54

    • Related Report
      2011 Final Research Report
  • [Journal Article] Coexistence of visceral fat accumulation and sleep-disordered breathing correlates with coronary artery disease2012

    • Author(s)
      Nakagawa Y, Kishida K., et al
    • Journal Title

      JAT

      Volume: (印刷中)

    • NAID

      130004444634

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing2012

    • Author(s)
      Nakanishi-Minami T, Kishida K., et al
    • Journal Title

      Diabetology & Metabolic Syndrome

      Volume: 4(1) Issue: 1 Pages: 6-6

    • DOI

      10.1186/1758-5996-4-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of sleep-disordered breathing in Japanese patients with acromegaly2012

    • Author(s)
      Kashine S, Kishida K., et al
    • Journal Title

      Endocrine Journal

      Volume: 59 Issue: 1 Pages: 31-38

    • DOI

      10.1507/endocrj.EJ11-0171

    • NAID

      130004443754

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of sleep-disordered breathing, visceral fat accumulation and adiponectin levels in patients with night-time onset of acute coronary syndrome2011

    • Author(s)
      Nakagawa Y, Kishida K, Mazaki T, Yokoi H, Nobuyoshi M, Funahashi T, Shimomura I.
    • Journal Title

      Am J Cardiol

      Volume: 108(9) Pages: 1266-71

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective Contribution of Waist Circumference Reduction on the Improvement of Sleep-disordered Breathing in Patients Hospitalized with Type 2 Diabetes Mellitus2011

    • Author(s)
      Kashine S, Kishida K, Funahashi T, Yasuda T, Okita K, Matsuzawa Y, Shimomura I.
    • Journal Title

      Intern Med

      Volume: 50(18) Pages: 1895-903

    • NAID

      130000969293

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue2011

    • Author(s)
      Nakagawa Y, Kishida K, Kihara S, Yoshida R, Funahashi T, Shimomura I.
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(3) Pages: 240-7

    • NAID

      130004444504

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 近畿支部教育セミナーまとめテーマ「睡眠時無呼吸と内科疾患」「糖尿病・内分泌疾患・メタボリックシンドロームと睡眠時無呼吸」日本内科学会専門医部会支部セミナー2011

    • Author(s)
      岸田堅
    • Journal Title

      日本内科学会雑誌

      Volume: 第100巻、第10号 Pages: 3084-3092

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Report from Kinki Chapter Educational Seminer : Sleep apnea syndrome in internal medicine2011

    • Author(s)
      Imagawa A, Kishida K., et al
    • Journal Title

      Nihon Naika Gakkai Zasshi

      Volume: 100(10) Pages: 3084-3092

    • NAID

      10030390456

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of sleep-disordered breathing, visceral fat accumulation and adiponectin levels in patients with night-time onset of acute coronary syndrome2011

    • Author(s)
      Nakagawa Y, Kishida K., et al
    • Journal Title

      Am J Cardiol

      Volume: 108(9) Issue: 9 Pages: 1266-1271

    • DOI

      10.1016/j.amjcard.2011.06.042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Contribution of Waist Circumference Reduction on the Improvement of Sleep-disordered Breathing in Patients Hospitalized with Type 2 Diabetes Mellitus2011

    • Author(s)
      Kashine S, Kishida K., et al
    • Journal Title

      Internal Medicine

      Volume: 50 Issue: 18 Pages: 1895-1903

    • DOI

      10.2169/internalmedicine.50.5669

    • NAID

      130000969293

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 2 diabetes and sleep-disordered breathing/sleep apnea ; Role of adipocytokines2011

    • Author(s)
      Kishida K.
    • Journal Title

      InTech Edited by : Colleen Croniger

      Pages: 267-276

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3.臨床-病態・治療編 13)血管糖尿病とアディポサイトカイン2011

    • Author(s)
      岸田堅
    • Journal Title

      Annual Book of Vascular Diabetes「血管糖尿病」フジメディカル出版

      Pages: 199-204

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 特集肥満症:診断と治療の進歩III肥満症とその合併症4.肥満症と血管合併症2011

    • Author(s)
      岸田堅
    • Journal Title

      日本内科学会雑誌

      Volume: 100(4) Pages: 958-965

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus2010

    • Author(s)
      Kashine S, Kishida K, Funahashi T, Nakagawa Y, Otuki M, Okita K, Iwahashi H, Kihara S, Nakamura T, Matsuzawa Y, Shimomura I.
    • Journal Title

      Metabolism

      Volume: 59(5) Pages: 690-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臨床6「アディポネクチンと睡眠時無呼吸症候群」2010

    • Author(s)
      岸田堅
    • Journal Title

      治療学

      Volume: 第44巻第11号 Pages: 70-74

    • Related Report
      2011 Final Research Report
  • [Journal Article] 睡眠時無呼吸症候群連載:知っておきたい血管医学用語2010

    • Author(s)
      岸田堅
    • Journal Title

      Vascular Medicine

      Volume: Vol.6. No.3 Pages: 66-71

    • Related Report
      2011 Final Research Report
  • [Journal Article] 「睡眠時無呼吸症候群と糖尿病(腎透析も含め)」特集「睡眠時無呼吸症候群-研究と臨床の新時代-」2010

    • Author(s)
      岸田堅
    • Journal Title

      THE LUNG perspectives

      Volume: 第68号vol.18 Pages: 3-3

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 「メタボリックシンドロームに合併しやすい臓器障害」「呼吸器~睡眠時無呼吸症候群を中心に~」2010

    • Author(s)
      岸田堅船橋徹
    • Journal Title

      Medicament News

      Pages: 11-13

    • Related Report
      2011 Final Research Report
  • [Journal Article] 「睡眠時無呼吸症候群」連載:知っておきたい血管医学用語2010

    • Author(s)
      岸田堅
    • Journal Title

      Vascular Medicine

      Volume: 6(3) Pages: 66-71

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アディポネクチンと睡眠時無呼吸症候群2010

    • Author(s)
      岸田堅
    • Journal Title

      アディポネクチン

      Volume: 44(11) Pages: 70-74

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling2009

    • Author(s)
      Nakagawa Y, Kishida K, Kihara S, Funahashi T. Shimomura I.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 382(1) Pages: 183-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠時無呼吸症候群(SAS)外来患者におけるSAS手帳導入の効果~適切な在宅医療提供を目的とした試み2009

    • Author(s)
      岸田堅船橋徹下村伊一郎
    • Journal Title

      ホルモンと臨床

      Volume: vol.57(No.11) Pages: 71-75

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠時無呼吸症候群患者における自己記入式質問表を用いた胃食道逆流症の評価とその臨床的特徴2009

    • Author(s)
      岸田堅, 船橋徹, 下村伊一郎
    • Journal Title

      ホルモンと臨床

      Volume: vol.57, No.11 Pages: 65-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドロームと睡眠時無呼吸症候群2009

    • Author(s)
      岸田堅
    • Journal Title

      メタボリックシンドロームBIO

      Volume: Clinica24(4) Pages: 24-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling2009

    • Author(s)
      Nakagawa Y, et al.
    • Journal Title

      Biochem Biophys Res Commun 382(1)

      Pages: 183-188

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus2009

    • Author(s)
      Kashine S, et al.
    • Journal Title

      Metabolism 13

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドロームと睡眠時無呼吸症候群2009

    • Author(s)
      岸田堅
    • Journal Title

      BIO Clinica (0919-8237) 24巻4号

      Pages: 316-322

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Nocturnal Falls of Adiponectin Levels in Steep Apnea with Abdominal Obesity and Impact of Hypoxia-Induced Dysregulated Adiponectin Production in Obese Murine Mesenteric Adipose Tissue.

    • Author(s)
      Nakagawa Yasuhiko, Tohru Funahashi, Kishida Ken., et al.
    • Journal Title

      J Atheroscler Thromb.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血管糖尿病の予防対策を目指した臨床検査の活用法-全身血管エコー検査と睡眠呼吸検査を中心に2011

    • Author(s)
      岸田堅
    • Organizer
      第64回日本臨床化学会近畿支部例会-生活習慣病の臨床・基礎研究の最先端
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管糖尿病の予防対策を目指した臨床検査の活用法~全身血管エコー検査と睡眠呼吸検査を中心に~2011

    • Author(s)
      岸田堅
    • Organizer
      第64回日本臨床化学会近畿支部例会
    • Place of Presentation
      大阪大学医学部保健学科(大阪府)(招待講演)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタボリックシンドローム医療update-分子メカニズムから地域予防対策まで-2011

    • Author(s)
      岸田堅
    • Organizer
      第2回産業医から診た糖尿病治療講演会
    • Place of Presentation
      守口ロイヤルパインズホテル(大阪府)(招待講演)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「睡眠時無呼吸と内科疾患」シンポジウム「糖尿病・内分泌疾患・メタボリックシンドロームと睡眠時無呼吸」2011

    • Author(s)
      岸田堅
    • Organizer
      第192回日本内科学会近畿地方会併催内科専門医部会近畿支部内科専門医セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Management of metabolic syndrome : Current practice and future perspectives The VACATION-J study : Visceral adiposity and atherosclerotic risk factor accumulation2011

    • Author(s)
      Ken Kishida
    • Organizer
      The 4^<rd> Annual Scientific Meeting of the Japan Atherosclerosis Society
    • Place of Presentation
      Sapporo (Hokkaido)(招待講演)
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大阪大学代謝血管学における睡眠呼吸障害と心血管病の取り組み2011

    • Author(s)
      岸田堅
    • Place of Presentation
      熊本
    • Year and Date
      2011-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 急性冠症候群における睡眠呼吸障害・内臓脂肪・アディポサイトカインの関連性に関する検討2011

    • Author(s)
      岸田堅
    • Organizer
      第7回関西循環器SDB研究会-循環器疾患における睡眠呼吸障害
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 急性冠症候群における睡眠呼吸障害・内臓脂肪・アディポサイトカインの関連性に関する検討2011

    • Author(s)
      岸田堅
    • Organizer
      第7回関西循環器SDB研究会
    • Place of Presentation
      ホテルグランヴィア大阪(大阪府)(招待講演)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] From bench to bedside「内臓脂肪蓄積学を基盤にした動脈硬化性心血管イベント予防対策」2011

    • Author(s)
      岸田堅
    • Organizer
      第54回日本糖尿病学会年次学術集会シンポジウム:糖尿病と動脈硬化
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 内臓脂肪蓄積学を基盤にした動脈硬化性心血管イベント予防対策2011

    • Author(s)
      岸田堅
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌市(北海道)(招待講演)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病・内分泌疾患・メタボリックシンドロームと睡眠時無呼吸2010

    • Author(s)
      岸田堅
    • Organizer
      第192回日本内科学会近畿地方会併催内科専門医部会近畿支部内科専門医セミナー「睡眠時無呼吸と内科疾患」
    • Place of Presentation
      大阪国際交流センター(大阪府)(招待講演)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床アディポサイエンス研究2010

    • Author(s)
      岸田堅
    • Organizer
      第15回アディポサイエンス研究会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 年齢別・性別による内臓脂肪評価と大阪大学におけるメタボリックシンドロームの全身血管病予防対策Age-and gender-specific evaluation of visceral fat accumulation with multiple risk factors and the Osaka University preventive strategy for systemic vascular disease in the metabolic syndrome2010

    • Author(s)
      岸田堅
    • Organizer
      第42回日本動脈硬化学会総会
    • Place of Presentation
      長良川国際会議場(岐阜県)(招待講演)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] メタボリックシンドロームと糖尿病-分子メカニズムから地域予防対策まで2010

    • Author(s)
      岸田堅
    • Organizer
      第36回神戸薬科大学卒後研修講座糖尿病診療の最近の話題
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 肥満メタボリックシンドロームの臨床2010

    • Author(s)
      岸田堅, 船橋徹, 下村伊一郎
    • Organizer
      第83回日本内分泌学会学術総会クリニカルアワー招待講演
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖尿病診療において知っておきたい疾患睡眠時無呼吸症候群2010

    • Author(s)
      岸田堅
    • Organizer
      Meet The Expert Conference
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Sleep apnea syndrome in Japanese diabetic patients and change of adiponectin concentrations during sleep2009

    • Author(s)
      樫根晋, 岸田堅
    • Organizer
      第41回日本動脈硬化学会総会
    • Place of Presentation
      海峡メッセ下関 (山口県)
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] The protective effect of adiponectin on pulmonary arterial remodeling induced by hypoxia in vivo2009

    • Author(s)
      中川靖彦, 岸田堅
    • Organizer
      第41回日本動脈硬化学会総会
    • Place of Presentation
      海峡メッセ下関 (山口県)
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 「アディポサイトカインと肥満症」「睡眠時無呼吸低呼吸症候群とその関連疾患におけるアディポネクチンの臨床・基礎解析」2009

    • Author(s)
      岸田堅
    • Organizer
      第82回日本内分泌学会学術総会シンポジウム
    • Place of Presentation
      群馬
    • Year and Date
      2009-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 睡眠時無呼吸低呼吸症候群とその関連疾患におけるアディポネクチンの臨床・基礎解析2009

    • Author(s)
      岸田堅
    • Organizer
      第82回日本内分泌学会総会
    • Place of Presentation
      群馬県民会館 (群馬県)
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸低呼吸症候群における夜間アディポネクチン低下およびその機序に関する研究2009

    • Author(s)
      中川靖彦, 岸田堅
    • Organizer
      第82回日本内分泌学会総会
    • Place of Presentation
      群馬県民会館 (群馬県)
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2型糖尿病入院症例における睡眠時無呼吸症候群の検討2009

    • Author(s)
      樫根晋, 岸田堅
    • Organizer
      第82回日本内分泌学会総会
    • Place of Presentation
      群馬県民会館 (群馬県)
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人糖尿病患者における睡眠時無呼吸症候群と夜間アディポネクチンの低下2009

    • Author(s)
      樫根晋, 岸田堅
    • Organizer
      第106回日本内科学会総会
    • Place of Presentation
      東京国際フォーラム (東京都)
    • Year and Date
      2009-04-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 「睡眠障害」コース「内分泌・代謝内科領域にみられる睡眠障害とその治療」2009

    • Author(s)
      岸田堅
    • Organizer
      社会人医学教育部門主催セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-26
    • Related Report
      2011 Final Research Report
  • [Book] Chapter 14. Type 2 diabetes and sleep-disordered breathing/ sleep apnea ; Role of adipocytokines.2011

    • Author(s)
      Kishida K.
    • Publisher
      InTech, Publication
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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