The study of the interactions between muscle and bone/mineral metabolism.

• Project/Area Number: 21591179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kinki University (2011); Kobe University (2009-2010)
• Principal Investigator: KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 筋 / 骨 / 骨芽細胞 / 分化 / シグナル / 筋肉 / 副甲状腺ホルモン / BMP-2

Research Abstract

The aim of our study is the identification of local ossification factors in muscle tissues and humoral bone anabolic factors produced from muscles in order to clarify the interactions between muscle and bone/mineral metabolism. We selected the factors with bone formation activity using the comprehensive gene analysis between muscle-derived cells and ossification signal-enhanced cells. Among them, Tmem119 is expected the factor, which locally induces muscle ossification. On the other hand, osteoglycin and FAM5C may be the candidates of novel humoral bone anabolic factors produced from muscles. We would like to proceed the further study of these factors as the putative targets for the development of the treatment of osteoporosis.

Research Products

• [Journal Article] Role of osteoglycin in the linkage between muscle and bone (2012)
  • Author(s): Tanaka K, Matsumoto E, Higashimaki E, Katagiri T, Sugimoto T, Seino S, Kaji H
  • Journal Title: J Biol Chem Volume: 287 Issue: 15 Pages: 11616-11628
  • DOI: 10.1074/jbc.m111.292193
  • Peer Reviewed
• [Journal Article] Impaired transforming growth factor-ss transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1(MEN1) (2012)
  • Author(s): Canaff L, Vanbellinghen JF, Kaji H, Goltzman D, Hendy GN
  • Journal Title: J Biol Chem Volume: 287 Issue: 11 Pages: 8584-8597
  • DOI: 10.1074/jbc.m112.341958
  • Peer Reviewed
• [Journal Article] Effects of serum from a fibrodysplasia ossificans profressiva patients on osteoblastic cells (2012)
  • Author(s): Hisa I, Kawara A, Katagiri T, Sugimoto T, Kaji H
  • Journal Title: Open J Endocr Metab Dis Volume: 2 Issue: 01 Pages: 1-6
  • DOI: 10.4236/ojemd.2012.21001
  • Peer Reviewed
• [Journal Article] FAM5C is a solubule osteoblast differentiation factor linking muscle to bone (2012)
  • Author(s): Tanaka K, Matsumoto E, Higashimaki Y, Sugimoto T, Seino S, Kaji H
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Issue: 1 Pages: 134-139
  • DOI: 10.1016/j.bbrc.2011.12.147
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway (2011)
  • Author(s): Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H
  • Journal Title: J Biol Chem Volume: 286 Issue: 11 Pages: 9787-9796
  • DOI: 10.1074/jbc.m110.179127
  • Peer Reviewed
• [Journal Article] Role of parathyroid hormone in bone fragility of postmenopausal women with vitamin D insufficiency (2011)
  • Author(s): Yamauchi M, Kaji H, Nawata K, Takaoka S, Yamaguchi T, Sugimoto T
  • Journal Title: Calcif Tissue Int Volume: 88 Issue: 5 Pages: 362-369
  • DOI: 10.1007/s00223-011-9464-6
  • Peer Reviewed
• [Journal Article] Menin interacts with ss-catenin in osteoblast differentiation (2011)
  • Author(s): Inoue Y, Hendy GN, Canaff L, Seino S, Kaji H
  • Journal Title: Horm Metab Res Volume: 43 Issue: 03 Pages: 183-187
  • DOI: 10.1055/s-0030-1270527
  • Peer Reviewed
• [Journal Article] Comparisons of serum sclerostin levels among patients with postmenopausal osteoporosis, primary hyperparathyroidism and osteomalacia (2011)
  • Author(s): Kaji H, Imanishi Y, Sugimoto T, Seino S
  • Journal Title: Exp Clin Endocr Diabet Volume: 119 Pages: 440-444
  • URL: http://dx.doi.org/10.1055/s-0031-1275661
  • Peer Reviewed
• [Journal Article] Alendronate induces mineralization in mouse osteoblastic MC3-T3-E1 cells : regulation of mineralization-related genes. (2010)
  • Author(s): 井上喜文
  • Journal Title: Experimental and Clinical Endocrinology, Diabetes Volume: 118 Pages: 719-723
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.
  • Author(s): 比佐伊都子
  • Journal Title: Journal of Biological Chemistry Volume: (2011 Jan 14 [Epub ahead of print])
  • Peer Reviewed
• [Journal Article] Menin interacts with β-catenin in osteoblast differentiation
  • Author(s): 井上喜文
  • Journal Title: Hormone and Metabolic Research Volume: (2011 Jan 24 [Epub ahead of print])
  • Peer Reviewed
• [Presentation] Interaction of the osteoblast differentiating factor, Tmem119, and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells (2011)
  • Author(s): Tanaka K
  • Organizer: 33th Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] Role of Tmem119 in the signaling of muscle ossification (2011)
  • Author(s): Tanaka K
  • Organizer: 2nd International Osteoporosis Foundation-Asian-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
• [Presentation] Novel parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation (2010)
  • Author(s): Hisa I
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] PTH及びSmad3シグナルにより誘導される新規因子Tmem119は骨芽細胞の分化を促進する (2009)
  • Author(s): 比佐伊都子
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2009-07-23