| Project/Area Number |
21591183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
JING Xuefeng 和歌山県立医科大学, 先端医学研究所, 講師 (70316123)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Kazushige 和歌山県立医科大学, 和歌山県立医科大学, 教授 (60178548)
SAWADA Takahiro 和歌山県立医科大学, 先端医学研究所.分子医学研究部, 助教 (00382325)
MIYAJIMA Masayasu 和歌山県立医科大学, 医学部, 助教 (80137257)
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| Co-Investigator(Renkei-kenkyūsha) |
CHIHARA Kazuo 神戸大学, 大学院医・学研究科, 客員教授 (00107955)
IIDA Keiji 神戸大学, 大学院医・学研究科, 助手 (80324911)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 成長障害 / 成長ホルモン / EphA4 / Eph / IGF1 / シグナル伝達 |
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| Research Abstract |
GH is regarded as an essential hormone for postnatal body growth that mainly works through IGF1 production in liver and other tissues, and the whole signaling process is named GH-IGF1 axis. We identified EphA4 as an essential binding partner of GHR. EphA4 binds to GHR and augments activation of the JAK2/STAT5B pathway. In addition, EphA4 directly binds to and phosphorylates STAT5B. Through these interactions, EphA4 transcriptionally enhances IGF1 production in liver cells as well as in others. Epha4 KO mice show short stature in an Epha4 gene dose-dependent fashion, and respond well to IGF1 but not to GH treatment.
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