Identification of key molecules by the analysis of pancreatic autopsy specimens in the development of fulminant type 1 diabetes

• Project/Area Number: 21591184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Osaka University
• Principal Investigator: IMAGAWA Akihisa 大阪大学, 医学系研究科, 講師 (80373108)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 劇症1型糖尿病 / 自然免疫 / toll-like receptor / ケモカイン / ウイルス / インスリン / 免疫組織化学 / Toll-like receptor / エンテロウイルス / in situ hybridization / innate immunity

Research Abstract

We analyzed pancreas specimens soon after the onset of fulminant type 1 diabetes. We revealed the expression of viral receptor and enterovirus RNA. The expressions of chemokine and its receptor were also observed. They are candidates of key molecules and viral infection, activation of innate immunity and homing of immunocytes by chemokine interaction may contribute to the development of fulminant type 1 diabetes.

Research Products

• [Journal Article] Glycated albumin to glycated hemoglobin ratio is a sensitive indicator of blood glucose variability in patients with fulminant Type 1 diabetes (2012)
  • Author(s): Matsumoto H, Imagawa A, et al.
  • Journal Title: Internal Med 2012 Volume: (in press)
  • NAID: 130002062134
  • Peer Reviewed
• [Journal Article] Insulin secretion capacity in normal glucose tolerance, impaired glucose tolerance, and diabetes in obese and non-obese Japanese subjects (2012)
  • Author(s): Iwahashi H, Imagawa A, et al.
  • Journal Title: J Diabetes Invest Volume: (in press)
  • Peer Reviewed
• [Journal Article] A case of long-standing autoimmune type 1 diabetes with common variable immunodeficiency (2012)
  • Author(s): Yamaoka M, Imagawa A, et al.
  • Journal Title: Diabetol Int. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Clinical features of Japanese type 2 diabetics with insulinogenic index in normal range after treatment of glucotoxicity (2012)
  • Author(s): Iwahashi H, Imagawa A, et al.
  • Journal Title: Diabetol Int. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Class II HLA genotype in fulminant type 1 diabetes. a nationwide survey with reference to GAD antibodies (2012)
  • Author(s): Tsutsumi C, Imagawa A, et al.
  • Journal Title: J Diabetes Invest Volume: 3 Pages: 62-69
  • Peer Reviewed
• [Journal Article] Liraglutide is effective in type 2 diabetic patients with sustained endogenous insulin secretion capacity (2012)
  • Author(s): Kozawa J, Imagawa A, et al.
  • Journal Title: J Diabetes Invest Volume: (in press)
  • Peer Reviewed
• [Journal Article] Preoperative insulin secretion ability and pancreatic parenchymal thickness as useful parameters for predicting postoperative insulin secretion in patients undergoing pancreatico-duodenectomy. (2012)
  • Author(s): Yoshikawa A, Imagawa A, et al.
  • Journal Title: Endocr J.
  • NAID: 10030816335
  • Peer Reviewed
• [Journal Article] 劇症1型糖尿 (2012)
  • Author(s): 芳川篤志、今川彰久
  • Journal Title: 病検査と技術 Volume: 40(4) Pages: 279-285
  • Peer Reviewed
• [Journal Article] Class II HLA genotype in fulminant type 1 diabetes-a nationwide survey with reference to GAD antibodies (2012)
  • Author(s): Tsutsumi C, Hanafusa T, et al
  • Journal Title: J Diabetes Investigation Volume: 3 Issue: 1 Pages: 62-69
  • DOI: 10.1111/j.2040-1124.2011.00139.x
  • Peer Reviewed
• [Journal Article] Preoperative insulin secretion ability and pancreatic parenchymal thickness as useful parameters for predicting postoperative insulin secretion in patients undergoing pancreaticoduodenectomy (2012)
  • Author(s): Yoshikawa A, Kozawa J, Okita K, Yoneda s, Okauchi Y, Uno S, Iwahashi H, Ohira T, Takiuchi D, Eguchi H, Takeda Y, Imagawa A, Shimomura I
  • Journal Title: Endocrine Journal Volume: 59 Issue: 5 Pages: 383-392
  • DOI: 10.1507/endocrj.EJ11-0322
  • NAID: 10030816335
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Liraglutide is effective in type 2 diabetic patients with sustained endogenous insulin secretion capacity (2012)
  • Author(s): Kozawa J, Inoue K, Iwamoto R, Kurashiki Y, Okauchi Y, Kashine S, Kitamura T, Maeda N, Okita K, Iwahashi H, Funahashi T, Imagawa A, Shimomura I
  • Journal Title: J Diabetes Invest Volume: (in press) Issue: 3 Pages: 294-297
  • DOI: 10.1111/j.2040-1124.2011.00168.x
  • Peer Reviewed
• [Journal Article] Clinical features of Japanese type 2 diabetics with insulinogenicindex in normal range after treatment of glucotoxicity (2012)
  • Author(s): Iwahashi H., et al
  • Journal Title: Diabetol.Int Volume: 2 Issue: 4 Pages: 208-213
  • DOI: 10.1007/s13340-011-0046-7
  • Peer Reviewed
• [Journal Article] A case of long-standing autoimmune type 1 diabetes with common variable immunodeficiency (2012)
  • Author(s): Yamaoka M, Kitamura T, Moriyama M, Shima Y, Haseda F, Okita K, Sakaguchi Y, Iwahashi H, Hanafusa T, Funahashi T, Nagata M, Otsuki M, Imagawa A, Shimomura I
  • Journal Title: Diabetol Int Volume: (in press) Issue: 1 Pages: 50-53
  • DOI: 10.1007/s13340-011-0049-4
  • Peer Reviewed
• [Journal Article] Insulin secretion capacity in normal glucose tolerance, impaired glucose tolerance, and diabetes in obese and non-obese Japanese subjects (2012)
  • Author(s): Iwahashi H, Okauchi Y, Ryo M, Noguchi M, Morita S, Kishida K, Okita K, Ohira T, Funahashi T, Nakamura T, Imasawa A, Shimomura I
  • Journal Title: J Diabetes Invest Volume: (in press) Issue: 3 Pages: 271-275
  • DOI: 10.1111/j.2040-1124.2011.00180.x
  • Peer Reviewed
• [Journal Article] Glycated albumin to glycated hemoglobin ratio is a sensitive indicator of blood glucose variability in patients with fulminant Type 1 diabetes (2012)
  • Author(s): Matsumoto H, Murase-Mishiba Y, Yamamoto N, Sugitatsu-Nakatsukasa S, Shibasaki S, Sano H, Terasaki J, Imagawa A, Hanafusa T
  • Journal Title: Internal Med Volume: (in press)
  • NAID: 130002062134
  • Peer Reviewed
• [Journal Article] Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference : a pilot study of obese Japanese patients with type 2 diabetes (2011)
  • Author(s): Inoue K, Imagawa A, et al.
  • Journal Title: Cardiovasc Diabetol Volume: 10(1) Pages: 109-109
  • Peer Reviewed
• [Journal Article] Right-sided acute suppurative thyroiditis caused by infectious endocarditis (2011)
  • Author(s): Inoue K, Imagawa A, et al.
  • Journal Title: Intern Med. Volume: 50(23) Pages: 2893-7
  • NAID: 130002062706
  • Peer Reviewed
• [Journal Article] Fulminant type 1 diabetes-an important subtype in East Asia (2011)
  • Author(s): Imagawa A, Hanafusa T.
  • Journal Title: Diabetes Metab Res Rev Volume: 27 Pages: 959-64
  • Peer Reviewed
• [Journal Article] Fulminant Type 1 Diabetes. Is it Virus-Induced Diabetes? (2011)
  • Author(s): Imagawa A.
  • Journal Title: J Med Virol Volume: 83 Pages: 1675-1675
  • Peer Reviewed
• [Journal Article] Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1, 178 middle-aged Japanese men-the Amagasaki Visceral Fat Study (2011)
  • Author(s): Okauchi Y, Imagawa A, et al.
  • Journal Title: Nutr Metab Volume: Nov 22
  • Peer Reviewed
• [Journal Article] Arterial stimulation and venous sampling for glucagonomas of the pancreas. (2011)
  • Author(s): Eguchi H, Imagawa A, et al.
  • Journal Title: Hepatogastroenterology
  • Peer Reviewed
• [Journal Article] Health Education" Hokenshido" Program Reduced Metabolic Syndrome in the Amagasaki Visceral Fat Study Three-Year Follow-up Study of 3, 174 Japanese Employees (2011)
  • Author(s): Ryo M, Imagawa A, et al.
  • Journal Title: Intern Med Volume: 50(16) Pages: 1643-8
  • NAID: 130000969363
  • Peer Reviewed
• [Journal Article] Type 1 Diabetes and Interferon Therapy : A nationwide survey in Japan (2011)
  • Author(s): Nakamura K, Imagawa A, et al.
  • Journal Title: Diabetes Care Volume: 34(9) Pages: 2084-2089
  • Peer Reviewed
• [Journal Article] Low CTLA-4 expression in CD4(+) helper T-cells in patients with fulminant type 1 diabetes (2011)
  • Author(s): Haseda F, Imagawa A, et al.
  • Journal Title: Immunol Lett Volume: 30
  • Peer Reviewed
• [Journal Article] Predictors of deterioration of glucose tolerance and effects of lifestyle intervention aimed at reducing visceral fat in normal glucose tolerance subjects with abdominal obesity (2011)
  • Author(s): Akita-Fukuda E, Imagawa A, et al.
  • Journal Title: J Diabetes Invest Volume: 2 Pages: 218-224
  • Peer Reviewed
• [Journal Article] Cellular hypoxia of pancreatic{ beta}-cells due to high levels of oxygen consumption for insulin secretion in vitro (2011)
  • Author(s): Sato Y, Imagawa A, et al.
  • Journal Title: J Biol Chem Volume: 286 Pages: 12524-32
  • Peer Reviewed
• [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, suppresses pancreatic{ beta}-cell destruction induced by encephalomyocarditis virus (2011)
  • Author(s): Sano H, Imagawa A, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 404(3) Pages: 756-61
  • Peer Reviewed
• [Journal Article] 劇症1型糖尿病.成因についての新しい知見を中心として (2011)
  • Author(s): 今川彰久、花房俊昭
  • Journal Title: Diabetes J Volume: 39(4) Pages: 158-166
  • Peer Reviewed
• [Journal Article] 劇症1型糖尿病 (2011)
  • Author(s): 今川彰久
  • Journal Title: 劇症1型糖尿病 Volume: 3(12) Pages: 139-146
  • NAID: 130006952950
• [Journal Article] 日本糖尿病学会I型糖尿病調査研究委員会緩徐進行1型糖尿病(slowly progressive insulin-dependent diabetes mellitus : SPIDDM)の臨床的特徴日本糖尿病学会1型糖尿病調査研究委員会緩徐進行1型糖尿病分科会報告(第一報) (2011)
  • Author(s): 田中昌一郎、今川彰久, 他(25名中12番め)
  • Journal Title: 糖尿病 Volume: 54(1) Pages: 65-75
  • Peer Reviewed
• [Journal Article] Cellular hypoxia of pancreatic β-cells due to high levels of oxygen consumption for insulin secretion in vitro (2011)
  • Author(s): Sato Y., et al
  • Journal Title: J Biol.Chem. Volume: 286 Issue: 14 Pages: 12524-12532
  • DOI: 10.1074/jbc.m110.194738
  • Peer Reviewed
• [Journal Article] Predictors of deterioration of glucose tolerance and effects of lifestyle intervention aimed at reducing visceral fat in normal glucose tolerance subjects with abdominal obesity (2011)
  • Author(s): Akita-Fukuda E, Iwahashi H, Okauchi Y, Okita K, Noguchi M, Ogawa T, Ryo M, Kishida K, Funahashi T, Nakamura T, Matsuzawa Y, Imagawa A, Shimomura I
  • Journal Title: J Diabetes Invest Volume: 2 Issue: 1 Pages: 218-24
  • DOI: 10.1186/1743-7075-8-57
  • Peer Reviewed
• [Journal Article] Low CTLA-4 expression in CD4+ helper T-Cells in patients with fulminant type 1 diabetes (2011)
  • Author(s): Haseda F, Hanafusa T, et al
  • Journal Title: Immunology Letters Volume: 139 Issue: 1-2 Pages: 80-86
  • DOI: 10.1016/j.imlet.2011.05.003
  • Peer Reviewed
• [Journal Article] Type 1 Diabetes and Interferon Therapy : A nationwide survey in Japan (2011)
  • Author(s): Nakamura K, Kawasaki E, Imagawa A, Awata T, Ikegami H, Uchigata Y, Kobayashi T, Shimada A, Nakanishi K, Makino H,Maruyama T, Hanafusa T, the Research Committee on Type 1 Diabetes of the Japan Diabetes Society
  • Journal Title: Diabetes Care Volume: 34 Issue: 9 Pages: 2084-9
  • DOI: 10.2337/dc10-2274
  • Peer Reviewed
• [Journal Article] Health Education "Hokenshido" Program Reduced Metabolic Syndrome in the Amagasaki Visceral Fat Study. Three-Year Follow-up Study of 3,174 Japanese Employees (2011)
  • Author(s): Ryo M, Nakamura T, Funahashi T, Noguchi M, Kishida K, Okauchi Y, Nishizawa H, Ogawa T, Kojima S, Ohira T, Okita K, Iwahashi H, Imagawa A, Maysuawa Y, Shimomura I
  • Journal Title: Internal Medicine Volume: 50 Issue: 16 Pages: 1643-1648
  • DOI: 10.2169/internalmedicine.50.5039
  • NAID: 130000969363
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Arterial Stimulation and Venous Sampling for Glucagonomas of the Pancreas (2011)
  • Author(s): Eguchi H, Tanemura M, Marubashi S, Kobayashi S, Wada H, Okita K, Iwahashi H, Imagawa A, Shimomura I, Osuga K, Umeshita K, Wakasa K, Mori M, Doki Y, Nagano H
  • Journal Title: Hepatogastroenterology Volume: 59 Issue: 113 Pages: 276-9
  • DOI: 10.5754/hge11392
  • Peer Reviewed
• [Journal Article] Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men-the Amagasaki Visceral Fat Study (2011)
  • Author(s): Okauchi Y, Kishida K, Funahashi T, Noguchi M, Ogawa T, Okita K, Iwahashi H, Ohira T, Imagawa A, Nakamura T, Shimomura I
  • Journal Title: Nutr Metab (Lond) Volume: 8 Issue: 1 Pages: 82-82
  • DOI: 10.1186/1743-7075-8-82
  • Peer Reviewed
• [Journal Article] Fulminant Type 1 Diabetes-Is it Virus-Induced Diabetes? (2011)
  • Author(s): Imagawa A
  • Journal Title: J Med Virol Volume: 83 Issue: 9 Pages: 1675-1675
  • DOI: 10.1002/jmv.22060
  • Peer Reviewed
• [Journal Article] Right-Sided Acute Suppurative Thyroiditis Caused by Infectious Endocarditis (2011)
  • Author(s): Inoue K, Kozawa J, Funahashi T, Nakata Y, Mitsui E, Kitamura T, Maeda N, Kishida,K, Otsuki M, Okita K, Iwahashi H, Imagawa A, Shimomura I
  • Journal Title: Internal Medicine Volume: 50 Issue: 23 Pages: 2893-2897
  • DOI: 10.2169/internalmedicine.50.5790
  • NAID: 130002062706
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference : a pilot study of obese Japanese patients with type 2 diabetes (2011)
  • Author(s): Inoue K, Maeda N, Kashine S, Fujishima Y, Kozawa J, Hiuge-Shimizu A, Okita K, Imagawa A, Funahashi T, Shimomura I
  • Journal Title: Cardiovasc Diabetol Volume: 10 Issue: 1 Pages: 109-109
  • DOI: 10.1186/1475-2840-10-109
  • Peer Reviewed
• [Journal Article] Cellular hypoxia of pancreatic β-cells due to high levels of oxygen consumption for insulin secretion in vitro (2011)
  • Author(s): Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M.
  • Journal Title: J Biol Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] 糖尿病の急性増悪 (2011)
  • Author(s): 秋田悦子、今川彰久
  • Journal Title: 救急医学 Volume: 35 Pages: 67-71
• [Journal Article] 緩徐進行1型糖尿病の臨床的特徴(委員会報告) (2011)
  • Author(s): 田中昌一郎、今川彰久, 他
  • Journal Title: 糖尿病 Volume: 54 Pages: 65-75
• [Journal Article] Insulin tolerance test predicts the effectiveness of insulin sensitizers in Japanese type 2 diabetic patients (2010)
  • Author(s): Kozawa J, Imagawa A, et al.
  • Journal Title: Diabetes Ther Volume: 1 Pages: 121-30
  • Peer Reviewed
• [Journal Article] Expression of chemokines, CXC chemokine ligand 10(CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes (2010)
  • Author(s): Uno S, Imagawa A, Saisho K, Okita K, Iwahashi H, Hanafusa T, Shimomura I.
  • Journal Title: Endocr J Volume: 57(11) Pages: 991-6
  • NAID: 10029586924
  • Peer Reviewed
• [Journal Article] Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers (2010)
  • Author(s): Okauchi Y, Imagawa A, et al.
  • Journal Title: J Atheroscler Thromb Volume: 17(12) Pages: 1237-1245
  • NAID: 130004444392
  • Peer Reviewed
• [Journal Article] Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes (2010)
  • Author(s): Shibasaki S, Imagawa A, et al.
  • Journal Title: J Diabetes Invest Volume: 1(6) Pages: 283-285
  • Peer Reviewed
• [Journal Article] Correlation of glycated albumin but not hemoglobin A1C with endogenous insulin secretion in fulminant type 1 diabetes mellitus (2010)
  • Author(s): Koga M, Imagawa A, et al.
  • Journal Title: J Diabetes Invest Volume: 1(6) Pages: 279-282
  • Peer Reviewed
• [Journal Article] 4-year follow-up of cardiovascular events and changes in visceral fat accumulation after health promotion program in the Amagasaki Visceral Fat Study (2010)
  • Author(s): Okauchi Y, Imagawa A, et al.
  • Journal Title: Atherosclerosis Volume: 212(2) Pages: 698-700
  • Peer Reviewed
• [Journal Article] Serum 1, 5-anhydroglucitol levels in patients with fulminant type 1 diabetes are lower than those in patients with type 2 diabetes (2010)
  • Author(s): Koga M, Imagawa A, et al.
  • Journal Title: Clin Biochem. Volume: 43(15) Pages: 1265-7
  • Peer Reviewed
• [Journal Article] Serum glycated albumin to haemoglobin A1C ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus (2010)
  • Author(s): Koga M, Imagawa A, et al.
  • Journal Title: Ann Clin Biochem Volume: 47(Pt 4) Pages: 313-7
  • Peer Reviewed
• [Journal Article] Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men (2010)
  • Author(s): Tamba S, Imagawa A, et al.
  • Journal Title: Atherosclerosis Volume: 211(2) Pages: 601-5
  • Peer Reviewed
• [Journal Article] Measurement of adiponectin production from differentiated metabolic stem cells (2010)
  • Author(s): Inomata-Kurashiki Y, Imagawa A, et al.
  • Journal Title: Horm Metab Res Volume: 42 Pages: 318-23
  • Peer Reviewed
• [Journal Article] Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes (2010)
  • Author(s): Kozawa J, Imagawa A, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 393 Pages: 410-3
  • Peer Reviewed
• [Journal Article] Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes (2010)
  • Author(s): Shibasaki S, Imagawa A, et al.
  • Journal Title: Endocr J Volume: 2 ; 57(3) Pages: 211-9
  • NAID: 10029583945
  • Peer Reviewed
• [Journal Article] 劇症1型糖尿病治療における問題点 (2010)
  • Author(s): 今川彰久
  • Journal Title: 糖尿病診療マスター Volume: 8(2) Pages: 209-212
• [Journal Article] 劇症1型糖尿病 (2010)
  • Author(s): 今川彰久、花房俊昭
  • Journal Title: 臨床病理 Volume: 58(3) Pages: 216-224
  • NAID: 130006952950
• [Journal Article] Expression of chemokines, CXC chemokine ligand 10 (CXCL 10)and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes. (2010)
  • Author(s): Uno S, Imagawa A, Saisho K, Okita K, Iwabashi H, Hanafusa T, Shimomura I.
  • Journal Title: Endocr J. Volume: 57 Pages: 991-996
  • NAID: 10029586924
  • Peer Reviewed
• [Journal Article] Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes. (2010)
  • Author(s): Shibasaki S, Imagawa A, Terasaki J, Hanafusa T.
  • Journal Title: J Diabetes Invest Volume: 1 Pages: 283-285
  • Peer Reviewed
• [Journal Article] Serum 1,5-anhydroglucitol levels in patients with fulminant type 1 diabetes are lower than those in patients with type 2 diabetea (2010)
  • Author(s): Koga M, Murai J, Saito H, Mukai M, Kasayama S, Imagawa A, Hanafusa T.
  • Journal Title: Clin Biochem Volume: 43 Pages: 1265-1267
  • Peer Reviewed
• [Journal Article] Effect of levo-thyroxine replacement on postprandial hyperlipidemia in patients with subclinical hypothyroidism (2010)
  • Author(s): Arishima T, Ito M, Sasaki I, Hiraiwa T, Kubota S, Fukata S, Amino N, Miyauchi A, Imagawa A, Hanafusa T.
  • Journal Title: Bulletin of the Osaka Medical College Volume: 56 Pages: 41-48
  • Peer Reviewed
• [Journal Article] Absolute Value of Bioelectrical Impedance Analysis-Measured Visceral Fat Area with Obesity-Related Cardiovascular Risk Factors in Japanese Workers (2010)
  • Author(s): Okauchi Y, Kishida K, Funahashi T, Noguchi M, Ogawa T, Ryo M, Okita K, Iwahashi H, Imagawa A, Nakamura T, Matsuzawa Y, Shimomura I.
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 1237-1245
  • NAID: 130004444392
  • Peer Reviewed
• [Journal Article] 4-year follow-up of cardiovascular events and changes in visceral fat accumulation after health promotion program in the Amagasaki Visceral Fat Study (2010)
  • Author(s): Okauchi Y, Kishida K, Funahashi T, Noguchi M, Morita S, Ogawa T, Imagawa A, Nakamura T, Matsuzawa Y, Shimomura I.
  • Journal Title: Atherosclerosis Volume: 212 Pages: 698-700
  • Peer Reviewed
• [Journal Article] Correlation of glycated albumin but not hemoglobin A1C with endogenous insulin secretion in fulminant type 1 diabetes mellitus (2010)
  • Author(s): Koga M, Murai J, Saito H, Kasayama S, Kobayashi T, Imagawa A, Hanafusa T.
  • Journal Title: J Diabetes Invest Volume: 1 Pages: 279-282
  • Peer Reviewed
• [Journal Article] Japan Diabetes Society's Committee on Research on Type 1 Diabetes.Serum glycated albumin to haemoglobin A(1C) ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus (2010)
  • Author(s): Koga M, Murai J, Saito H, Kasayama S, Imagawa A, Hanafusa T, Kobayashi T.
  • Journal Title: Ann Clin Bibchem Volume: 47 Pages: 313-317
  • Peer Reviewed
• [Journal Article] Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men (2010)
  • Author(s): Tamba S, Nakatsuji H, Kishida K, Noguchi M, Ogawa T, Okauchi Y, Nishizawa H, Imagawa A, Nakamura T, Matsuzawa Y, Funahashi T, Sbimomura I.
  • Journal Title: Atherosclerosis Volume: 211 Pages: 601-605
  • Peer Reviewed
• [Journal Article] Measurement of adiponectin production from differentiated metabolic stem cells (2010)
  • Author(s): Inomata-Kurashiki Y, Maeda K, Yoshioka E, Fukuhara A, Imagawa A, Otsuki M, Shimomura I.
  • Journal Title: Horm Metab Res Volume: 42 Pages: 318-323
  • Peer Reviewed
• [Journal Article] Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes (2010)
  • Author(s): Shibasaki S, Imagawa A, Tauriainen S, Iino M, Oikarinen M, Abiru H, Tamaki K, Seino H, Nishi K, Takase I, Okada Y, Uno S, Murase-Mishiba Y, Terasaki J, Makino H, Shimomura I, Hyoty H, Hanafusa T.
  • Journal Title: Endocr J Volume: 57 Pages: 211-219
  • NAID: 10029583945
  • Peer Reviewed
• [Journal Article] 1型糖尿病 (2010)
  • Author(s): 中田伸輔、今川彰久
  • Journal Title: 糖尿病ケア(秋期増刊) Volume: 84 Pages: 92-96
• [Journal Article] 劇症1型糖尿病の診断基準は? (2010)
  • Author(s): 今川彰久
  • Journal Title: 肥満と糖尿病 Volume: 9 Pages: 377-378
• [Journal Article] Expression of Toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes (2010)
  • Author(s): Shibasaki S, Imagawa A, 他
  • Journal Title: Endocrine J (印刷中)
  • NAID: 10029583945
  • Peer Reviewed
• [Journal Article] Differential association of HLA with three subtypes of type 1 diabetes : fulminant, slowly progressive and acute-onset (2009)
  • Author(s): Kawabata Y, Imagawa A, et al.
  • Journal Title: Diabetologia Volume: 52(12) Pages: 2513-21
  • Peer Reviewed
• [Journal Article] Changes in serum adiponectin concentrations correlate with changes in BMI, waist circumference, and estimated visceral fat area in middle-aged general population (2009)
  • Author(s): Okauchi Y, Imagawa A, et al.
  • Journal Title: Diabetes Care Volume: 32(10)
  • Peer Reviewed
• [Journal Article] Fulminant type 1 diabetes as an important exception to the new diagnostic criteria using HbA(1c)-response to the International Expert Committee (2009)
  • Author(s): Imagawa A, Hanafusa T.
  • Journal Title: Diabetologia Volume: Nov ; 52(11) Pages: 2464-5
  • Peer Reviewed
• [Journal Article] Glucose enhances collectrin protein expression in insulin-producing MIN6 beta cells (2009)
  • Author(s): Saisho K, Imagawa A, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 389 Pages: 133-7
  • Peer Reviewed
• [Journal Article] 劇症1型糖尿病 (2009)
  • Author(s): 今川彰久、花房俊昭
  • Journal Title: 糖尿病 Volume: 52(8) Pages: 669-671
  • NAID: 130006952950
  • Peer Reviewed
• [Journal Article] 劇症1型糖尿病-最新動向 (2009)
  • Author(s): 今川彰久
  • Journal Title: 医学のあゆみ Volume: 229(11) Pages: 1086-7
• [Journal Article] 劇症1型糖尿病の病因と病態(3)急性期・慢性期の病態と治療 (2009)
  • Author(s): 今川彰久
  • Journal Title: プラクティス Volume: 26(3) Pages: 239-241
• [Journal Article] 見逃してはいけない糖尿病-劇症1型糖尿病 (2009)
  • Author(s): 今川彰久、花房俊昭
  • Journal Title: 日本医師会雑誌 Volume: 138(1) Pages: 33-33
• [Journal Article] 劇症1型糖尿病の病因と病態(2)ウイルス感染の関与 (2009)
  • Author(s): 今川彰久
  • Journal Title: プラクティス Volume: 26(2) Pages: 129-131
• [Journal Article] 劇症1型糖尿病の病因と病態(1)遺伝因子 (2009)
  • Author(s): 今川彰久
  • Journal Title: プラクティス Volume: 26(1) Pages: 11-13
• [Journal Article] Fulminant type 1 diabetes as an important exception to the new diagnostic criteria using HbA1c-response to the International Expert Committee (2009)
  • Author(s): Imagawa A, Hanafusa T.
  • Journal Title: Diabetologia 52 Pages: 2464-2465
  • Peer Reviewed
• [Journal Article] Differential association of HLA with three subtypes of type 1 diabetes : fulminant, slowly progressive and acute-onset (2009)
  • Author(s): Kawabata Y, Imagawa A, 他
  • Journal Title: Diabetologia 52 Pages: 2513-2521
  • Peer Reviewed
• [Presentation] Fulminant type 1 diabetes (2011)
  • Author(s): Imagawa A, Hanafusa T.
  • Organizer: 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Tokyo
  • Year and Date: 2011-10-21
• [Presentation] Symposium "Type 1 diabetes in East Asia" Fulminant type 1 diabetes (2011)
  • Author(s): Imagawa A
  • Organizer: 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-10-21
• [Presentation] Fulminant type 1 diabetes. is it a unique Asian Phenomenon? (2011)
  • Author(s): Imagawa A, Hanafusa T.
  • Organizer: The 3^<rd> Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-07-23
• [Presentation] Symposium "Type 1 diabetes" Fulminant type 1 diabetes-is it aunique Asian Phenomenon? (2011)
  • Author(s): Imagawa A
  • Organizer: The 3^<rd> Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-07-23
• [Presentation] 1型糖尿病における膵β細胞傷害機構 (2011)
  • Author(s): 今川彰久
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] シンポジウム「1型糖尿病の成因と予防:新しい展開と洞察」1型糖尿病における膵ss細胞傷害機構 (2011)
  • Author(s): 今川彰久
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] 劇症1型糖尿病はどこまで解明されたか (2011)
  • Author(s): 今川彰久
  • Organizer: 第45回糖尿病学の進歩
  • Place of Presentation: 福岡
  • Year and Date: 2011-02-20
• [Presentation] 劇症1型糖尿病はどこまで解明されたか (2011)
  • Author(s): 今川彰久
  • Organizer: 第45回糖尿病学の進歩
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-02-20
• [Presentation] 劇症1型糖尿病の新展開 (2010)
  • Author(s): 今川彰久
  • Organizer: 第47回日本糖尿病学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-13
• [Presentation] 劇症1型糖尿病の新展開 (2010)
  • Author(s): 今川彰久
  • Organizer: 第47回日本糖尿病学会近畿地方会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-11-13
• [Presentation] Fulminant diabetes immunology (2010)
  • Author(s): Imagawa A, Hanafusa T.
  • Organizer: The 2^<nd> international symposium of Korea national diabetes program
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-11-03
• [Presentation] Symposium "Important subtypes within diabetes : LADA/SPIDDM and Fulminant" Fulminant diabetes immunology (2010)
  • Author(s): 今川彰久
  • Organizer: The 2^<nd> international symposium of Korea national diabetes program
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2010-11-03
• [Presentation] Fulminant type 1 diabetes-an important subtype in East Asia (2010)
  • Author(s): Imagawa A, Hanafusa T.
  • Organizer: The 11^<th> Meeting of the Immunology of Diabetes Society
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2010-11-02
• [Presentation] Symposium "Important subtype within type 1 diabetes" Fulminant type 1 diabetes an important subtype in East Asia (2010)
  • Author(s): 今川彰久
  • Organizer: The 11^<th> Meeting of the Immunology of Diabetes Society
  • Place of Presentation: Incheon, Korea(招待講演)
  • Year and Date: 2010-11-02
• [Presentation] Fulminant type 1 Diabetes-is it virus-induced diabetes? (2010)
  • Author(s): Imagawa A.
  • Organizer: VIDIS group meeting at EASD
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-09-19
• [Presentation] Lecture Fulminant type 1 Diabetes -is it virus-induced diabetes? (2010)
  • Author(s): 今川彰久
  • Organizer: VIDIS group meeting at EASD
  • Place of Presentation: Stockholm, Sweden(招待講演)
  • Year and Date: 2010-09-19
• [Presentation] 劇症1型糖尿病の成因 (2010)
  • Author(s): 今川彰久
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] シンポジウム「1型糖尿病の新しい展開」:劇症1型糖尿病の成因 (2010)
  • Author(s): 今川彰久
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-05-27
• [Presentation] Panel discussion "Professionalism saves our patients" opening remarks (2010)
  • Author(s): 今川彰久
  • Organizer: American College of Physicians 2010 Scientific Meeting
  • Place of Presentation: Tokyo
  • Year and Date: 2010-04-10
• [Presentation] レクチャー劇症1型糖尿病の臨床 (2010)
  • Author(s): 今川彰久
  • Organizer: 第44回糖尿病学の進歩
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-05
• [Presentation] Fulminant type 1 diabetes. an important entity in East Asia (2009)
  • Author(s): Imagawa A.
  • Organizer: 15th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-22
• [Presentation] 劇症1型糖尿病の発症機序 (2009)
  • Author(s): 今川彰久
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] Discovery and establishment of fulminant type 1 diabetes. from a patient to clinical entity (2009)
  • Author(s): Imagawa A.
  • Organizer: 6th ACP Japan Chapter Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2009-04-18
• [Presentation] Class II HLA genotype in fulminant type 1 diabetes (2009)
  • Author(s): Tsutsumi C, Imagawa, A, 他
  • Organizer: 第69回米国糖尿病学会
  • Place of Presentation: ニューオーリンズ (米国)
• [Book] 劇症1型糖尿病の病態と治療別冊プラクティスブリットル糖尿病の病態と治療・管理のコツ (2012)
  • Author(s): 細川吉弥、今川彰久
  • Publisher: 医歯薬出版、東京
• [Book] Fulminan type 1 diabetes. In Immunoendocrinology : Scientific and clinical aspects. (2011)
  • Author(s): Imagawa A, Hanafusa T.
  • Publisher: Humana Press, New York
• [Book] 劇症1型糖尿病はどこまで解明されたか糖尿病の療育指導2011 (2011)
  • Author(s): 今川彰久
  • Publisher: 診断と治療社、東京
• [Book] Fulminan type 1 diabetes. In Immunoendocrinology : Scientific and clinical aspects. (2011)
  • Author(s): Imagawa A, Hanafusa T.(分担執筆)
  • Publisher: Humana Press, New York, USA
• [Book] 糖尿病性昏睡(高浸透圧高血糖症候群、乳酸アシドーシス)今日の治療指針2011年度版 (2011)
  • Author(s): 今川彰久
  • Publisher: 医学書院、東京
• [Book] 劇症1型糖尿病の臨床糖尿病の療育指導2010 (2010)
  • Author(s): 今川彰久
  • Publisher: 診断と治療社、東京
• [Book] 劇症1型糖尿病の臨床糖尿病の療育指導2010 (2010)
  • Author(s): 今川彰久
  • Publisher: 日本糖尿病学会編、診断と治療社、東京
• [Book] 1型糖尿病今日の治療指針 (2009)
  • Author(s): 今川彰久
  • Publisher: 医学書院、東京