Genetic factors to Graves 'ophthalmopathy, other complications and the intractability to anti-thyroid drugs in patients with Graves' disease
| Project/Area Number |
21591185
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANI Junichi 久留米大学, 医学部, 講師 (80361096)
KAKU Hiroo 久留米大学, 医学部, 助教 (50320239)
KATO Tamotsu 久留米大学, 医学部, 助教 (00341363)
MURAISHI Kazuhisa 久留米大学, 医学部, 助教 (60529296)
TOKUBUCHI Ichiro 久留米大学, 医学部, 助教 (40529301)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | バセドウ病 / バセドウ病眼症 / 遺伝子多型 / TSH受容体抗体 / TBX21 / 臨床 / 内科 / 遺伝子 |
|---|
| Research Abstract |
The aim of the study was to investigate possible genetic factors to the development of ophthalmopathy, type 1 diabetes, or ANCA related vasculitis in patients with Graves' disease. We also investigated the intractability to anti-thyroid drugs. There was a significant association between TSH receptor gene polymorphism(rs179247) and the severity of ophthalmopathy. PPAR. gene polymorphism(Pro12Ala) was related with proptosis. TBX21 gene polymorphism was related to the responsiveness by steroid pulse therapy for severe ophthalmopathy. PTPN22 gene polymorphism was related with the development of anti-GAD antibody, which was a marker of type 1 diabetes. CTLA4 gene polymorphism(A49G) was related with the intractability to anti-thyroid drugs.
|
Report
(4 results)
Research Products
(56 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Clinical characteristics of thyroid abnormalities induced by sunitinib treatment in Japanese patients with renal cell carcinoma2010
Author(s)
Sato S, Muraishi K, Tani J, Sasaki Y, Tokubuchi I, Tajiri Y, Yamada K, Suekane S, Miyajima J, Matsuoka K, Hiromatsu Y.
-
Journal Title
Endocrine Journal
Volume: 57
Pages: 873-880
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 低用量のアイソトープ治療後euthyroidismで寛解しているMarine-Lenhart Syndromeの一例2011
Author(s)
吉信聡子, 佐藤秀一, 村石和久, 徳渕市朗, 鶴田宗久, 加藤全, 賀来寛雄, 谷淳一, 田尻祐司, 山田研太郎, 廣松雄治
Organizer
第54回日本甲状腺学会学術集会
Place of Presentation
大阪
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
