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Genetic factors to Graves 'ophthalmopathy, other complications and the intractability to anti-thyroid drugs in patients with Graves' disease

Research Project

Project/Area Number 21591185
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKurume University

Principal Investigator

HIROMATSU Yuji  久留米大学, 医学部, 教授 (10201740)

Co-Investigator(Kenkyū-buntansha) TANI Junichi  久留米大学, 医学部, 講師 (80361096)
KAKU Hiroo  久留米大学, 医学部, 助教 (50320239)
KATO Tamotsu  久留米大学, 医学部, 助教 (00341363)
MURAISHI Kazuhisa  久留米大学, 医学部, 助教 (60529296)
TOKUBUCHI Ichiro  久留米大学, 医学部, 助教 (40529301)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsバセドウ病 / バセドウ病眼症 / 遺伝子多型 / TSH受容体抗体 / TBX21 / 臨床 / 内科 / 遺伝子
Research Abstract

The aim of the study was to investigate possible genetic factors to the development of ophthalmopathy, type 1 diabetes, or ANCA related vasculitis in patients with Graves' disease. We also investigated the intractability to anti-thyroid drugs. There was a significant association between TSH receptor gene polymorphism(rs179247) and the severity of ophthalmopathy. PPAR. gene polymorphism(Pro12Ala) was related with proptosis. TBX21 gene polymorphism was related to the responsiveness by steroid pulse therapy for severe ophthalmopathy. PTPN22 gene polymorphism was related with the development of anti-GAD antibody, which was a marker of type 1 diabetes. CTLA4 gene polymorphism(A49G) was related with the intractability to anti-thyroid drugs.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (56 results)

All 2012 2011 2010 2009

All Journal Article (21 results) (of which Peer Reviewed: 6 results) Presentation (31 results) Book (4 results)

  • [Journal Article] 私の処方亜急性甲状腺炎2012

    • Author(s)
      廣松雄治
    • Journal Title

      Modern Physician

      Volume: 32 Pages: 246-246

    • Related Report
      2011 Annual Research Report
  • [Journal Article] プロピルチオウラシル中止の6年後に再燃した重症抗好中球細胞質抗体関連血管炎の1例2011

    • Author(s)
      加藤全, 廣松雄治, 加藤智子, 江口洋幸, 徳渕市朗, 村石和久, 賀来寛雄, 谷淳一, 山田研太郎
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 33巻5号 Pages: 499-505

    • NAID

      40019154904

    • Related Report
      2011 Final Research Report
  • [Journal Article] 甲状腺疾患最新のガイドラインと知見を用いたこれからの実地診療2011

    • Author(s)
      廣松雄治
    • Journal Title

      Medical Practice

      Volume: 28巻11号 Pages: 1908-1915

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【バセドウ病の診療に必要な知識】バセドウ病眼症への対処法2011

    • Author(s)
      廣松雄治
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 32巻5号 Pages: 468-473

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 【甲状腺疾患へのアプローチ】甲状腺疾患の最近のトピックスバセドウ病眼症2011

    • Author(s)
      廣松雄治
    • Journal Title

      Modern Physician

      Volume: 31巻4号 Pages: 449-452

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] バセドウ病眼症の診断と治療ガイドライン実地医家がどのようにかかわるか2011

    • Author(s)
      廣松雄治
    • Journal Title

      Medical Practice

      Volume: 28 Pages: 1908-1915

    • Related Report
      2011 Annual Research Report
  • [Journal Article] プロピルチオウラシル中止の6年後に再燃した重症抗好中球細胞質抗体関連血管炎の1例2011

    • Author(s)
      加藤全
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 33 Pages: 499-505

    • NAID

      40019154904

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose uptake in patients with papillary thyroid cancer2011

    • Author(s)
      Kaida H
    • Journal Title

      Nucl Med Commun

      Volume: 32 Pages: 690-698

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between (99m) Tc-tetrofosmin thyroid scintigraphy and mitogen-activated protein kinase in papillary thyroid cancer patients2011

    • Author(s)
      Baba K
    • Journal Title

      Jpn J Radiol

      Volume: 29 Pages: 633-539

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basedow病眼症2010

    • Author(s)
      廣松雄治
    • Journal Title

      日本内科学会雑誌

      Volume: 99巻 Pages: 755-762

    • NAID

      10026331077

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Papillary carcinoma, diffuse sclerosing variantの1例2010

    • Author(s)
      城谷克郎
    • Journal Title

      ホルモンと臨床

      Volume: 58巻 Pages: 86-90

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Clinical characteristics of thyroid abnormalities induced by sunitinib treatment in Japanese patients with renal cell carcinoma2010

    • Author(s)
      Sato S, Muraishi K, Tani J, Sasaki Y, Tokubuchi I, Tajiri Y, Yamada K, Suekane S, Miyajima J, Matsuoka K, Hiromatsu Y.
    • Journal Title

      Endocrine Journal

      Volume: 57 Pages: 873-880

    • NAID

      10029586528

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Management of Graves orbitopathy on the basis of accurate diagnosis : the role of MRI2010

    • Author(s)
      Yuji Hiromatsu
    • Journal Title

      Hot Thyroidology

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 甲状腺関連眼症2010

    • Author(s)
      廣松雄治
    • Journal Title

      内科

      Volume: 107巻 Pages: 12-16

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] バセドウ病の臨床-見過ごしていませんか甲状腺疾患-2010

    • Author(s)
      廣松雄治
    • Journal Title

      臨床と研究

      Volume: 88巻 Pages: 269-273

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Clinical characteristics of thyroid abnormalities induced by sunitinib treatment in Japanese patients with renal cell carcinoma.2010

    • Author(s)
      Shuichi Sato
    • Journal Title

      Endocrine Journal

      Volume: 57 Pages: 873-880

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of Graves'orbitopathy on the basis of accurate diagnosis : the role of MRI.2010

    • Author(s)
      Yuji Hiromatsu
    • Journal Title

      Hot Thyroidology

      Volume: 09/10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 甲状腺眼症update2009

    • Author(s)
      谷淳一、廣松雄治
    • Journal Title

      ホルモンと臨床

      Volume: 57巻 Pages: 691-699

    • Related Report
      2011 Final Research Report
  • [Journal Article] 甲状腺眼症における最近の話題2009

    • Author(s)
      谷淳一、廣松雄治
    • Journal Title

      Current Therapy

      Volume: 27巻 Pages: 152-156

    • Related Report
      2011 Final Research Report
  • [Journal Article] 甲状腺眼症 update2009

    • Author(s)
      谷淳一、廣松雄治
    • Journal Title

      ホルモンと臨床 57

      Pages: 691-699

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 甲状腺眼症における最近の話題2009

    • Author(s)
      谷淳一、廣松雄治
    • Journal Title

      Current Therapy 27

      Pages: 152-156

    • Related Report
      2009 Annual Research Report
  • [Presentation] バセドウ病眼症におけるMc4を用いたTSH受容体抗体の意義2012

    • Author(s)
      廣松雄治, 江口洋幸, 村石和久, 加藤全, 佐藤秀一, 賀来寛雄, 谷淳一
    • Organizer
      第21回臨床内分泌代謝
    • Place of Presentation
      浜松
    • Related Report
      2011 Final Research Report
  • [Presentation] バセドウ病眼症におけるMc4を用いたTSH受容体抗体の意義2012

    • Author(s)
      廣松雄治
    • Organizer
      第21回臨床内分泌代謝update
    • Place of Presentation
      浜松
    • Related Report
      2011 Annual Research Report
  • [Presentation] 壮年期に発症した大腸菌による急性化膿性甲状腺炎の1例2011

    • Author(s)
      村石和久, 平尾沙織, 加藤全, 加藤智子, 佐藤秀一, 谷淳一, 山田研太郎, 廣松雄治
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 低用量のアイソトープ治療後euthyroidismで寛解しているMarine-Lenhart Syndromeの一例2011

    • Author(s)
      吉信聡子, 佐藤秀一, 村石和久, 徳渕市朗, 鶴田宗久, 加藤全, 賀来寛雄, 谷淳一, 田尻祐司, 山田研太郎, 廣松雄治
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 刺激型、阻害型抗TSH受容体抗体価の変動により亢進症から低下症へ移行し再び亢進症をきたしたバセドウ病の1例2011

    • Author(s)
      平尾沙織, 大重たまみ, 加藤全, 加藤智子, 佐藤秀一, 賀来寛雄, 谷淳一, 山田研太郎, 廣松雄治
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] TBX21遺伝子多型はバセドウ病眼症の発症と関連している2011

    • Author(s)
      江口洋幸, 田中利依, 江頭知香, 村石和久, 鶴田宗久, 賀来寛雄, 谷淳一, 山田研太郎, 廣松雄治
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 悪性眼球突出症・甲状腺ホルモン不応症悪性眼球突出症の診断・治療ガイドライン2011

    • Author(s)
      廣松雄治
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of nuclear transcription factor peoxisome proliferators-activated receptor-γ(PPARγ) gene polymorphism with susceptibility to Graves ophthalmopathy2011

    • Author(s)
      Y. Hiromatsu, H. Eguchi, K. Muraishi, H. Kaku, J. Tani
    • Organizer
      81st Annual Meeting of the American Thyroid Association
    • Place of Presentation
      Indian Wells, California, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本人バセドウ病におけるIL-4遺伝子多型の検討2011

    • Author(s)
      田中利依, 江口洋幸, 江頭知香, 村石和久, 賀来寛雄, 谷淳一, 山田研太郎, 廣松雄治
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ステロイドパルス療法中に重篤な肝機能障害を認めたバセドウ眼症の一例2011

    • Author(s)
      鶴田宗久, 平尾沙織, 村石和久, 佐藤秀一, 谷淳一, 廣松雄治, 山田研太郎
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 悪性眼球突出症の診断・治療ガイドライン2011

    • Author(s)
      廣松雄治
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 悪性眼球突出症の診断・治療ガイドライン2011

    • Author(s)
      廣松雄治
    • Organizer
      第54回日本甲状腺学会学術集会
    • Place of Presentation
      大阪(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association of nuclear transcription factor peoxisome proliferators-activated receptor-γ (PPARγ) gene polymorphism with susceptibility to Graves' ophthalmopathy2011

    • Author(s)
      Hiromatsu Y
    • Organizer
      81^<st> Annual Meeting of the American Thyroid Association
    • Place of Presentation
      Indian Wells, California, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 悪性眼球突出症の診断・治療ガイドライン2011

    • Author(s)
      廣松雄治
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Current Perspective on the Pathogenesis of Graves ophthalmopathy2010

    • Author(s)
      Y. Hiromatsu
    • Organizer
      Autumn Meeting of Korean Endocrine Society
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Current Perspective on the Pathogenesis of Graves' ophthalmopathy.2010

    • Author(s)
      Yuji Hiromatsu
    • Organizer
      2010 Autumn Meeting of Korean Endocrine Society
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Medical management of Graves ophthalmopathy : role of MRI2010

    • Author(s)
      Yuji Hiromatsu
    • Organizer
      Thyroid Satellite Symposium of ICE 2010
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Medical management of Graves' ophthalmopathy : role of MRI2010

    • Author(s)
      廣松雄治
    • Organizer
      Thyroid Satellite Symposium of ICE 2010
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人バセドウ病におけるTSH受容体遺伝子多型の検討2010

    • Author(s)
      田中利依, 他
    • Organizer
      第53回日本甲状腺学会学術総会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] バセドウ病眼症の診断と治療のガイドライン2010

    • Author(s)
      廣松雄治
    • Organizer
      第53回日本甲状腺学会学術総会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Prevalence of anti-collagen XIII antibodies in Japanese thyroid-associated ophthalmopathy patients2010

    • Author(s)
      Jun-ichi Tani、Yuji Hiromatsu, et. al
    • Organizer
      14^<th> International congress of endocrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] PTUによるANCA関連腎炎・間質性肺炎により死亡した1例2010

    • Author(s)
      加藤全
    • Organizer
      第83回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 日本人甲状腺眼症における抗Calsequestrin1抗体の有用性について2009

    • Author(s)
      谷淳一
    • Organizer
      第52回日本甲状腺学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] PTU加療中に出現したP-ANCA陽性バセドウ病患者の臨床的特徴2009

    • Author(s)
      加藤全
    • Organizer
      第52回日本甲状腺学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 日本人バセドウ病眼症におけるPPARγ遺伝子多型の検討2009

    • Author(s)
      田中利依
    • Organizer
      第52回日本甲状腺学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] バセドウ病悪性眼球突出症の診断基準と治療指針の作成2009

    • Author(s)
      廣松雄治
    • Organizer
      第52回日本甲状腺学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Progress in the pathogenesis and management of Graves ophthalmopathy2009

    • Author(s)
      Yuji Hiromatsu
    • Organizer
      9th Asia and Oceania Thyroid Association Congress
    • Place of Presentation
      Nagoya
    • Related Report
      2011 Final Research Report
  • [Presentation] バセドウ病における抗GAD抗体出現と遺伝子多型2009

    • Author(s)
      廣松雄治
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] バセドウ病悪性眼球突出症の診断基準と治療方針2009

    • Author(s)
      谷淳一
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 日本人甲状腺眼症における抗 Calsequestrin 1抗体の有用性について2009

    • Author(s)
      谷淳一
    • Organizer
      第52回日本甲状腺学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] Progress in the pathogenesis and management of Graves' ophthalmopathy2009

    • Author(s)
      廣松雄治
    • Organizer
      9th Asia and Oceania Thyroid Association Congress
    • Place of Presentation
      Nagoya
    • Related Report
      2009 Annual Research Report
  • [Book] バセドウ病眼症大関武彦(監修)ステロイドガイドブック20112011

    • Author(s)
      廣松雄治
    • Publisher
      協和企画
    • Related Report
      2011 Final Research Report
  • [Book] 甲状腺疾患診療マニュアル2009

    • Author(s)
      谷淳一、廣松雄治
    • Total Pages
      168
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] よくわかる甲状腺疾患改定第2版2009

    • Author(s)
      谷淳一、廣松雄治
    • Total Pages
      514
    • Publisher
      永井書店
    • Related Report
      2011 Final Research Report
  • [Book] よくわかる甲状腺疾患 改定第2版2009

    • Author(s)
      谷淳一、廣松雄治
    • Total Pages
      514
    • Publisher
      永井書店
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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