Innate immune activation and thyroid autoimmunity

• Project/Area Number: 21591187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: SUZUKI Koichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (20206478)
• Research Collaborator: KAWASHIMA Akira 国立感染症研究所, ハンセン病研究センター感染制御部, 協力研究員 (60624913) ; AKAMA Takeshi 国立感染症研究所, ハンセン病研究センター感染制御部, 流動研究員 (20575253) ; TANIGAWA Kazunari 国立感染症研究所, ハンセン病研究センター感染制御部, 協力研究員 (10443110)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 甲状腺 / 自己免疫疾患 / 自然免疫 / 自己免疫 / 2本鎖DNA / インターフェロン / サイトカイン / ケモカイン / サイログロブリン / 甲状線

Research Abstract

Activation of innate and acquired immune responses, which can be induced by infection, inflammation or tissue injury, may impact the development of autoimmunity. Using cultured thyroid cells, we show that cell injury prompts the release of genomic DNA into the cytosol, which is associated with the production of type I interferons(IFNs), inflammatory cytokines and chemokines. Molecules necessary for antigen processing and presentation to lymphocytes are also induced in thyroid cells by injury. In order to identify molecules responsible for sensing cytosolic dsDNA, we directly identified the cellular proteins that bound a dsDNA sepharose column by mass spectrometry. Our analysis identified genomic DNA fragments released by cell injury are recognized by extrachromosomal histone H2B, which results in the activation of genes involved in both innate and acquired immune responses in thyroid cells and suppression of thyroid function.

Research Products

• [Journal Article] Fragments of Genomic DNA Released by Injured Cells Activate Innate Immunity and Suppress Endocrine Function in the Thyroid (2011)
  • Author(s): Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii K, Hirano H, Kimura H, Sakai T, Ishii N, Suzuki K
  • Journal Title: Endocrinology Volume: 152(4) Issue: 4 Pages: 1702-1712
  • DOI: 10.1210/en.2010-1132
• [Journal Article] Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth (2011)
  • Author(s): Suzuki K, Kawashima A, Yoshihara A, Akama T, Sue M, Yoshida A and Kimura HJ
  • Journal Title: J Endocrinol Volume: 209 Issue: 2 Pages: 169-174
  • DOI: 10.1530/joe-10-0486
• [Journal Article] Innate immune activation and thyroid autoimmunity (2011)
  • Author(s): Kawashima A, Tanigawa K, Akama T, Yoshihara A, Ishii N, Suzuki K
  • Journal Title: J Clin Endocrinol Metab Volume: 96(12) Issue: 12 Pages: 3661-3671
  • DOI: 10.1210/jc.2011-1568
• [Journal Article] Bacterial DNA promotes proliferation of rat pancreatic stellate cells thorough toll-like receptor 9 : potential mechanisms for bacterially induced fibrosis (2011)
  • Author(s): Nakamura T, Ito T, Oono T, Igarashi H, Fujimori N, Uchida M, Niina Y, Yasuda M, Suzuki K, Takayanagi R
  • Journal Title: Pancreas Volume: 40 Pages: 823-831
  • Peer Reviewed
• [Journal Article] Identification of microRNAs that mediate thyroid cell growth induced by TSH (2011)
  • Author(s): Akama T, Sue M, Kawashima A, Wu H, Tanigawa K, Suzuki S, Hayashi M, Yoshihara A, Ishido Y, Ishii N, Suzuki K
  • Journal Title: Mol Endocrinol Volume: 26 Issue: 3 Pages: 823-831
  • DOI: 10.1210/me.2011-1004
  • Peer Reviewed
• [Journal Article] 自己免疫性甲状腺疾患発症の免疫学的機序の基礎と最近の進歩 (2011)
  • Author(s): 鈴木幸一、川島晃
  • Journal Title: Medical Practice Volume: 26 Pages: 1950-1954
• [Journal Article] Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum. 420 : 611-615, 2012 (2011)
  • Author(s): Sue M, Hayashi M, Kawashima A, Akama T, Tanigawa K, Yoshihara A, Hara T, Ishido Y, Ito T, Takahashi S-I, Ishii N, Suzuki K
  • Journal Title: Biochem Biophys Res Commun Volume: 420 Pages: 611-615
  • Peer Reviewed
• [Journal Article] Thyroglobulin(Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation (2010)
  • Author(s): Noguchi Y, Harii N, Giuliani C, Tatsuno I, Suzuki K and Kohn LD
  • Journal Title: Biochem Biophys Res Commun Volume: 391 Issue: 1 Pages: 890-894
  • DOI: 10.1016/j.bbrc.2009.11.158
• [Journal Article] Iodide-induced chemokine and gene related to immunological function in cultured human thyroid follicles in the presence of TSH (2010)
  • Author(s): Yamazaki K, Tanigawa K, Suzuki K, Yamada E, Yamada T, Takano K, Obara T and Sato K
  • Journal Title: Thyroid Volume: 20(1) Issue: 1 Pages: 67-76
  • DOI: 10.1089/thy.2009.0242
• [Journal Article] Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells (2010)
  • Author(s): Suzuki K, Kimura H, Wu H, Kudo N, Kim WB, Suzuki S, Yoshida A, Caturegli P and Kohn LD
  • Journal Title: Biochem Biophys Res Commun Volume: 393 Issue: 2 Pages: 286-290
  • DOI: 10.1016/j.bbrc.2010.01.123
• [Journal Article] Extra-chromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA (2010)
  • Author(s): Kobiyama K, Takeshita F, Jounai N, Sakaue-Sawano A, Miyawaki A, Ishii KJ, Kawai T, Sasaki S, Hirano H, Ishii N, Okuda K, Suzuki K
  • Journal Title: J Virol Volume: 84 Pages: 822-832
  • Peer Reviewed
• [Journal Article] Modulation of intracellular signaling using protein transduction technology (2010)
  • Author(s): Kobiyama K, Jounai N, Ishii KJ, Horii T, Suzuki K, Ryo A, Takeshita F
  • Journal Title: Crit Rev Immunol Volume: 30 Pages: 395-421
  • Peer Reviewed
• [Journal Article] Iodide-induced chemokine and gene related to immunological function in cultured human thyroid follicles in the presence of TSH (2010)
  • Author(s): Yamazaki K, Tanigawa K, Suzuki K, Yamada F, Yamada T, Takano K, Obara T, Sato K
  • Journal Title: Thyroid Volume: 20 Pages: 67-76
  • Peer Reviewed
• [Journal Article] Thyroglobulin(Tg)induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation (2010)
  • Author(s): Noguchi Y, Harii N, Giuliani C, Tatsuno I, Suzuki K, Kohn LD
  • Journal Title: Bioehem Biophys Res Commun Volume: 391 Pages: 890-894
  • Peer Reviewed
• [Journal Article] Excess iodide decreases transcription of NIS and VEGF genes in rat FRTI-5 thyroid cells (2010)
  • Author(s): Suzuki K, Kimura H, Wu H, Kudo N, Kim WB, Suzuki S, Yoshida A, Caturegli P, Kohn LD
  • Journal Title: Biochein Biophys Res Coinmun Volume: 393 Pages: 286-290
  • Peer Reviewed
• [Journal Article] Regenerative Potentials of the Murine Thyroid in Experimental Autoimmune Thyroiditis : Role of CD24 (2009)
  • Author(s): Chen CY, Kimura H, Westra W, Kimura M, Landek-Salgado M, Suzuki K, Rose NR and Caturegli P
  • Journal Title: Endocrinology Volume: 150 Issue: 1 Pages: 492-499
  • DOI: 10.1210/en.2008-0639
• [Journal Article] Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases (2009)
  • Author(s): Yoshida A, Hisatome I, Taniguchi S-I, Shirayoshi Y, Yamamoto Y, Miake J, Okura T, Akama T, Igawa O, Shigemasa C, Kamijo K, Ikuyama S, Caturegli P and Suzuki K
  • Journal Title: J Clin Endocrinol Metab Volume: 94(2) Issue: 2 Pages: 442-8
  • DOI: 10.1210/jc.2008-1732
• [Journal Article] Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function (2009)
  • Author(s): Kimura HJ, Rocchi R, Landek-Salgado MA, Suzuki K, Chen CY, Kimura M, Rose NR, Caturegli P
  • Journal Title: Endocrinology Volume: 150(7) Issue: 7 Pages: 3409-3416
  • DOI: 10.1210/en.2008-1769
• [Journal Article] Expression of a thyroglobulin(Tg) variant in mouse kidney glomerulus (2009)
  • Author(s): Wu H, Suzuki S, Sellitti D, Doi SQ, Tanigawa K, Aizawa S, Akama T, Kawashima A, Mishima M, Ishii N, Yoshida A, Hisatome I, Koles NL, Katoh R and Suzuki K
  • Journal Title: Biochem Biophys Res Commun Volume: 389 Issue: 2 Pages: 269-273
  • DOI: 10.1016/j.bbrc.2009.08.129
• [Journal Article] Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism : studies in human and mice (2009)
  • Author(s): Kimura JH, Chen YC, Tzou SC, Rocchi R, Landek-Salgado M, Suzuki K, Kimura M, Rose NR and Caturegli P
  • Journal Title: PLoS One Volume: 4 Issue: 11 Pages: e7857-e7857
  • DOI: 10.1371/journal.pone.0007857
• [Journal Article] Regenerative Potentials of the Murine Thyroid in Experimental Autoimmune Thyroiditis : Role of CD24 (2009)
  • Author(s): Chen CY, Kimura H, Westra W, Kimura M, Landek-Salgado M, Suzuki K, Rose NR, Caturegli P.
  • Journal Title: Endocrinology 150 Pages: 492-499
  • Peer Reviewed
• [Journal Article] A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant (2009)
  • Author(s): Kobiyama K, Takeshita F, Ishii KJ, Koyama S, Aoshi T, Akira S, Sakaue-Sawano A, Miyawaki A, Yamanaka Y, Hirano H, Suzuki K, Okuda K.
  • Journal Title: J Immunol 182 Pages: 1593-1601
  • Peer Reviewed
• [Journal Article] Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases (2009)
  • Author(s): Yoshida A, Hisatome I, Taniguchi S-I, Shirayoshi Y, Yamamoto Y, Miake J, Okura T, Akama T, Igawa O, Shigemasa C, Kamijo K, Ikuyama S, Caturegli P, Suzuki K.
  • Journal Title: J Clin Endocrinol Metab 94 Pages: 442-448
  • Peer Reviewed
• [Journal Article] Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function (2009)
  • Author(s): Kimura HJ, Rocchi R, Landek-Salgado MA, Suzuki K, Chen CY, Kimura M, Rose NR, Caturegli P.
  • Journal Title: Endocrinology 150 Pages: 3409-3416
  • Peer Reviewed
• [Journal Article] Expression of a thyroglobulin(Tg)variant in mouse kidney glomerulus (2009)
  • Author(s): Wu H, Suzuki S, Sellitti D, Doi SQ, Tanigawa K, Aizawa S, Akama T, Kawashima A, Mishima M, Ishii N, Yoshida A, Hisatome I, Koles NL, Katoh R, Suzuki K.
  • Journal Title: Biochem Biophys Res Commun 389 Pages: 269-273
  • Peer Reviewed
• [Journal Article] Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism : studies in human and mice (2009)
  • Author(s): Kimura JH, Chen YC, Tzou SC, Rocchi R, Landek-Salgado M, Suzuki K, Kimura M, Rose NR, Caturegli P.
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Presentation] PTUはラット甲状腺FRTL-5細胞においてTSH非存在下でMS遺伝子発現とヨード取り込みを誘導する (2012)
  • Author(s): 須江麻里子、赤間剛、川島晃、中村はな、原武史、谷川和也、Huhehasi Wu、吉原彩、石藤雄子、石井則久、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第28回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-21
• [Presentation] 甲状腺が持つ免疫能-自己免疫性甲状腺疾患との関わり- (2011)
  • Author(s): 鈴木幸一
  • Organizer: 第4回久留米・佐賀甲状腺研究会
  • Place of Presentation: 佐賀
  • Year and Date: 2011-10-15
• [Presentation] 甲状腺が持つ免疫能-自己免疫性甲状腺疾患との関わり- (2011)
  • Author(s): 鈴木幸一
  • Organizer: 第4回久留米・佐賀甲状腺研究会、特別講演
  • Place of Presentation: 佐賀
  • Year and Date: 2011-10-15
• [Presentation] サイログロブリン(Tg)によるDUOX遺伝子発現調節 (2011)
  • Author(s): 吉原彩、谷川和也、川島晃、Huhehasi Wu、赤間剛、須江麻里子、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第27回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-22
• [Presentation] 自己免疫性甲状腺疾患発症の免疫学的機序の基礎と最近の進歩 (2011)
  • Author(s): 鈴木幸一、川島晃、赤間剛、吉原彩、須江麻里子
  • Organizer: 第27回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-22
• [Presentation] Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid (2011)
  • Author(s): A. Kawashima, F. Takeshita, K. Ishii, K. Suzuki
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 甲状腺特異的IFNgトランスジェニックマウスの慢性炎症発現はC57BL/6系統群に限られ、MHCハプロタイプに依存しない (2011)
  • Author(s): 木村博昭、鈴木幸一、高橋将文、Patrizio Caturegli
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪
• [Presentation] DUOX2によるH_2O_2産生はサイログロブリン(Tg)によって制御される (2011)
  • Author(s): 吉原彩、川島晃、赤間剛、須江麻里子、Huhehasi Wu、谷川和也、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Regulation of H_2O_2 generation by thyroglobulin in FRTL-5 (2011)
  • Author(s): A. Yoshihara, A. Kawashima, K. Tanigawa, H. Wu, T. Akama, M. Sue, Y. Ishido, N. Hiroi, G. Yoshino, K. Suzuki
  • Organizer: 35^<th> Meeting of The European Thyroid Association
  • Place of Presentation: Krakow, Poland
• [Presentation] microRNAs regulate thyroid cell proliferation induced by TSH and thyroglobulin (2011)
  • Author(s): T. Akama, A. Kawashima, H. Wu, K. Tanigawa, M. Sue, A. Yoshihara, Y. Ishido, K. Suzuki
  • Organizer: 35^<th> Meeting of The European Thyroid Association
  • Place of Presentation: Krakow, Poland
• [Presentation] 慢性甲状腺炎における免疫プロテアソームの役割 (2011)
  • Author(s): 木村博昭、鈴木幸一、臼井文武、Noel R. Rose、Patrizio Caturegli、高橋将文
  • Organizer: 第32回日本炎症再生医学会
  • Place of Presentation: 京都
• [Presentation] ペンドレッド症候群原因遺伝子PDS(SLC26A4)の発現分布と機能 (2011)
  • Author(s): 鈴木幸一
  • Organizer: 第84回内分泌学会
  • Place of Presentation: 神戸
• [Presentation] サイログロブリンによるDUOX2を介した甲状腺ホルモン生成制御 (2011)
  • Author(s): 吉原彩、須江麻里子、赤間剛、Huhehasi Wu、川島晃、谷川和也、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸
• [Presentation] PTUはラットFRTL-5細胞においてNIS遺伝子発現とヨード取り込みを誘導する (2011)
  • Author(s): 須江麻里子、中村はな、川島晃、赤間剛、Huhehasi Wu、谷川和也、吉原彩、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸
• [Presentation] ペンドレッド症候群原因遺伝子PDS(SLC26A4)の発現分布と機能 (2011)
  • Author(s): 鈴木幸一
  • Organizer: 第84回日本内分泌学会、シンポジウム
  • Place of Presentation: 神戸
• [Presentation] DUOX2によるH2O2産生はサイログロブリン(Tg)によって制御される (2011)
  • Author(s): 吉原彩、川島晃、赤間剛、須江麻里子、Huhehasi Wu、谷川和也、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第54回日本甲状腺学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 無機ヨードはヒト甲状腺濾胞培養系においてICAM1やケモカイン(CCL2, CXCL8, CXCL14)を活性化し甲状腺機能抑制的に作用する (2010)
  • Author(s): 山崎和子、谷川和也、鈴木幸一、山田恵美子、山田哲、高野加寿恵、佐藤幹二
  • Organizer: 第26回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-23
• [Presentation] 無機ヨードはヒト甲状腺濾胞培養系においてICAMIやケモカイン(CCL2.CXCL8.CXCLI4)を活性化し甲状腺機能抑制的に作用する (2010)
  • Author(s): 山崎和子、谷川和也、鈴木幸一、山田恵美子、山田哲、高野加寿恵, 佐藤幹二
  • Organizer: 第26回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-23
• [Presentation] microRNA(miRNA)によって制御される甲状腺細胞増殖機構の解明 (2010)
  • Author(s): 赤間剛、川島晃、Huhehasi Wu、谷川和也、須江麻里子、吉原彩、石藤雄子、鈴木幸一
  • Organizer: 第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] DNAマイクロアレイを用いたサイログロブリン(Tg)による甲状腺遺伝子発現変化の検討 (2010)
  • Author(s): 吉原彩、須江麻里子、赤間剛、Huhehasi Wu、川島晃、谷川和也、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] サイログロブリン(Tg)はAkt経路およびMAPK経路を活性化し、TSHとは異なる経路で細胞増殖を誘導する (2010)
  • Author(s): 須江麻里子、赤間剛、川島晃、Huhehasi Wu、谷川和也、吉原彩、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] 甲状腺細胞傷害による自然・獲得免疫反応の誘導機構の解明 (2010)
  • Author(s): 川島晃、谷川和也、Huhehasi Wu、赤間剛、須江麻理子、吉原彩、石藤雄子、鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] TSHやthyroglobulinによる甲状腺細胞増殖を制御するmiRNAとその標的遺伝子の同定 (2010)
  • Author(s): 赤間剛、川島晃、Huhehasi Wu、谷川和也、須江麻里子、吉原彩、石藤雄子、鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] 免疫プロテアソームサブユニットLMP7異常は橋本病に類似した病態を誘導する (2010)
  • Author(s): 木村博昭、鈴木幸一、高橋将文、Patrizio Caturegli
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] サイログロブリンによる甲状腺細胞増殖や遺伝子発現調節機構の解明。研究創成賞講演 (2010)
  • Author(s): 鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] Innate immunity and thyroid autoimmunity. International Molecular Thyroidology Symposium (2010)
  • Author(s): K. Suzuki, A. Kawashima, K. Tanigawa, H. Wu, T. Akama, M. Sue, A. Yoshihara, Y. Ishido and H. Kimura
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] 甲状腺自己免疫発症や機能低下誘導に関与する新しい因子:病原体、ゲノムDNA断片と免疫プロテアソーム (2010)
  • Author(s): 鈴木幸一、川島晃、谷川和也、Huhehasi Wu、赤間剛、須江麻里子、吉原彩、石藤雄子、木村博昭
  • Organizer: 第14回日本内分泌病理学会、シンポジウム「難治性甲状腺疾患と病理」
  • Place of Presentation: 京都
• [Presentation] Thyroglobulin(Tg) activates MAPK pathways to induce thyroid cell growth (2010)
  • Author(s): M. Sue, T. Akama, A. Kawashima, H. Wu, K. Tanigawa, Y. Ishido, A. Yoshihara, N. Hiroi, K. Tsuboi, G. Yoshino, K. Suzuki
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] TSH and thyroglobulin modulate microRNA expression that regulate thyroid cell growth (2010)
  • Author(s): T. Akama, A. Kawashima, H. Wu, K. Tanigawa, M. Sue, A. Yoshihara, Y. Ishido, K. Suzuki
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] Expression of a thyroglobulin(Tg) variant in mouse kidney glomerulus (2010)
  • Author(s): H. Wu, S. Suzuki, DF. Sellitti, SQ. Doi, K. Tanigawa, S. Aizawa, T. Akama, A. Kawashima, A. Yoshida, I. Hisatome, N. L. Koles, K. Suzuki
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] Anti-pendrin antibody, a novel autoantibody, in autoimmune and inflammatory thyroid disease (2010)
  • Author(s): K. Matsuzawa, A. Yoshida, S. Taniguchi, H. Ohkura, S. Izawa, C. Shigemasa, K. Kamijyo, S. Fukata, J. Tajiri, E. Nishihara, A. Miyauchi, K. Suzuki
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] The effect of anti-thyroid drugs on Sodium-Iodide-Symporter(NIS) expression in rat thyroid FRTL-5 cells (2010)
  • Author(s): M. Sue, H. Nakamura, A. Kawashima, Y. Ishido, H. Wu, T. Akama, K. Tanigawa, LD. Kohn, K. Suzuki
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Identification of microRNAs that regulate thyroid physiology (2010)
  • Author(s): T. Akama, A. Kawashima, H. Wu, K. Tanigawa, M. Sue, Y. Ishido and K. Suzuki
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Anti-Pendrin antibody in autoimmune and inflammatory thyroid disease (2010)
  • Author(s): A. Yoshida, K. Matsuzawa, Y. Ohkura, S. Izawa, K. Kamijo, S. Hukata, J. Tajiri, E. Nishihara, S. Taniguchi, C. Shigemasa and K. Suzuki
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Thyroid transcription factor-1(TTF-1) in thyroid cancers and its application to therapeutics.(JES-Sponsored Symposia. Molecular aspects of endocrine tumor update.) (2010)
  • Author(s): R. Katoh, T. Kondo, K. Suzuki
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] 無機ヨードはリンパ球ではなく甲状腺細胞に作用してchemokine(CCL2, CXCL8, CXCL14)を活性化し甲状腺機能抑制的に作用する (2010)
  • Author(s): 山崎和子、谷川和也、鈴木幸一、山田恵美子、山田哲、高野加寿恵、佐藤幹二
  • Organizer: 第83回日本内分泌学会
  • Place of Presentation: 京都
• [Presentation] The effect of anti-thyroid drugs on Sodium-Iodide-Symporter(NIS)expression in rat thyroid FRIL-5 cells (2010)
  • Author(s): Mariko Sue, Hannah Nakamura, Akira Kawashirna, Yuko Ishido, Huhehasi Wu, Takeshi Akama, Kazunari Tanigawa, Leonard D, Kohn, Koichi, Suzuki
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Identification of microRNAs that regulate thyroid physiology (2010)
  • Author(s): Takeshi Akama, Akira Kawashima, Huhehasi Wu, Kazunari Tanigawa, Mariko Sue, Yuko Ishido, Koichi Suzuki
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Anti-Pendrin antibody in autoimmune and inflammatory thyroid disease (2010)
  • Author(s): Akio Yoshida, Kazuhiko Matsuzawa, Yuko Ohkura, Shyoichiro Izawa, Keiichi Kamijo, Shyuji Hukata, Junichi Tajiri, Eijun Nishihara, Shinichi Taniguchi, Chiaki Shigemasa, Koichi Suzuki
  • Organizer: 4th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Thyroid transcription factor-I(TTF-1)in thyroid cancers and its application to therapeutics (2010)
  • Author(s): Ryohei Katoh, Tetsuo Kondo, Koichi Suzuki
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan(招待講演)
• [Presentation] 無機ヨードはリンパ球ではなく甲状腺細胞に作用してchemokine(CCC, 2, CXCL8, CXCL14)を活性化し甲状腺機能抑制的に作用する (2010)
  • Author(s): 山崎和子、谷川和也、鈴木幸一、山田恵美子、山田哲、高野加寿恵、佐藤幹二
  • Organizer: 第83回日本内分泌学会
  • Place of Presentation: 京都
• [Presentation] Thvroglobulin(Tg)activates MAPK pathways to induce thyroid cell growth (2010)
  • Author(s): M.Sue, T.Akama, A.Kawashima, H.Wu, K.Tanigawa, Y.Ishido, A.Yoshihara, N.Hiroi, K.Tsuboi, G.Yoshino, K.Suzuk.
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] Expression of a thvroglobulin(Tg)variant in mouse kidnev glonierulus (2010)
  • Author(s): H.Wu, S.Suzuki, D.F.Sellitti, S.Q.Doi, K.Tanigawa, S.Aizawa, T.Akama, A.Kawashima, A.Yoshida, I.Hisatome, N.L.Koles, K.Suzuki
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] Anti-pendrin antibody, a novel autoantibody in autoimmune and inflammatory thyroid disease (2010)
  • Author(s): K.Matsuzava, A.Yoshida, S.Taniguchi, H.Ohkura, S.Izawa, C.Shigernasa, K.Kamijyo, S.Fukata., J.Tajiri, E.Nishihara, A.Miyauchi, K.Suzuki
  • Organizer: 14th International Thyroid Congress
  • Place of Presentation: Paris
• [Presentation] 甲状腺自己免疫発症や機能低ド誘導に関与する新しい因子:病原体、ゲノムDNA断片と免疫プロテアソーム (2010)
  • Author(s): 鈴木幸一、川島晃、谷川和也、Huhehasi Wu、赤間剛、須江麻里子、吉原彩、石藤雄子、木村博昭
  • Organizer: 第14回日本内分泌病理学会
  • Place of Presentation: 京都
• [Presentation] サイログロブリン(Tg)はAkt経路およびMAPK経路を活性化し、 TSHとは異なる経路で細胞増殖を誘導する (2010)
  • Author(s): 須江麻里子、赤間剛、川島晃、Huhehasi Wu、谷川和也、吉原彩、石藤雄子、廣井直樹、芳野原、鈴木幸一
  • Organizer: 第53回日本甲状線学会
  • Place of Presentation: 長崎
• [Presentation] 甲状腺細胞傷害によろ露然・獲得免疫反応の誘導機構の解明 (2010)
  • Author(s): 川島晃、谷川和也、Huhehasi Wu、赤間剛、須江麻理子、吉原彩、石藤雄子、鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] TSIIやtlnrorriobulinによろ甲状腺細胞増殖を制御するmiRNAとその標的遺伝itの同定 (2010)
  • Author(s): 赤間剛、川島晃、Huhehasi Wu、谷川和也、須江麻里子、吉原彩、石藤雄子、鈴木幸一
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎
• [Presentation] Innate immunity and thyroid autoimmunity (2010)
  • Author(s): K.Suzuki, A.Kawashima, K.Tanigawa, H.Wu, T.Akama, M.Sue, A.Yoshihara, Y.Ishido, H.Kimura
  • Organizer: International Molecular Thyroidology Symposium
  • Place of Presentation: 長崎(招待講演)
• [Presentation] microRNA(miRNA)によって制御される甲状腺細胞増殖機構の解明 (2010)
  • Author(s): 赤間剛、川島晃、Huhehasi Wu、谷川和也、須江麻里子、吉原彩、石藤雄子、鈴木幸一
  • Organizer: 第33回日本分子生物学会年会、第83回田本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 甲状腺基礎研究から示唆される、甲状腺の増殖、自己免疫および機能異常症の新しい病因 (2009)
  • Author(s): 鈴木幸一
  • Organizer: 第1回城南肥満内分泌研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-06
• [Presentation] 甲状腺基礎研究から示唆される、甲状腺の増殖、自己免疫および機能異常症の新しい病因 (2009)
  • Author(s): 鈴木幸一
  • Organizer: 第1回城南肥満内分泌研究会、特別講演
  • Place of Presentation: 東京
  • Year and Date: 2009-10-06
• [Presentation] 甲状腺細胞傷害による内因性アジュバンド放出が自己抗原提示の誘因となる可能性 (2009)
  • Author(s): 川島晃、谷川和也、Huhehasi Wu、赤間剛、林もゆる、石藤雄子、石井則久、武下文彦、平野久、鈴木幸一
  • Organizer: 第25回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] 無機ヨードがヒト甲状腺濾胞細胞の免疫に関連した遺伝子発現に及ぼす効果:Chemokine およびその受容体についての検討 (2009)
  • Author(s): 山崎和子、山田恵美子、山田哲、鈴木幸一、高野加寿恵、佐藤幹二
  • Organizer: 第25回甲状腺病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] ペンドレッド症候群の基礎と臨床 (2009)
  • Author(s): 吉田明雄、谷口晋一、重政千秋、上條桂一、深田修司、田尻淳一、西原永潤、宮内昭、谷山松雄、鈴木幸一
  • Organizer: 第52回日本甲状腺学会、専門医教育セミナー
  • Place of Presentation: 名古屋
• [Presentation] 抗甲状腺薬が甲状腺機能遺伝子発現に与える影響の違い (2009)
  • Author(s): 須江麻里子、中村はな、川島晃、石藤雄子、Huhehasi Wu、赤間剛、谷川和也、Leonard D. Kohn、鈴木幸一
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
• [Presentation] 新しい破壊性甲状腺病態マーカー:抗ペンドリン抗体 (2009)
  • Author(s): 松澤和彦、谷口晋一、大倉裕子、伊澤正一郎、西原永潤、宮内昭、深田修司、上條桂一、重政千秋、鈴木幸一、吉田明雄
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
• [Presentation] 橋本病の病態形成には免疫プロテアソームが関与する (2009)
  • Author(s): 木村博昭、鈴木幸一、Melissa A. Landek-Salgado, Patrizio Caturegli
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
• [Presentation] 無機ヨードはヒト甲状腺細胞培養系においてICAM1やケモカイン(CCL2, CXCL8, CXCL14)の産生を増強し、甲状腺機能に抑制的に作用する (2009)
  • Author(s): 山崎和子、谷川和也、鈴木幸一、山田恵美子、山田哲、高野加寿恵、佐藤幹二
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
• [Presentation] サイログロブリンが持つ細胞増殖・遺伝子発現調節機能を担う活性部位の同定 (2009)
  • Author(s): 鈴木幸一
  • Organizer: 第52回日本甲状腺学会、研究創成賞講演
  • Place of Presentation: 名古屋
• [Presentation] Infiltrating macrophages induce oncocytic phenotype in thyr-IFNγtransgenic mouse thyroids : A critical role of LMP2 in the pathogenesis of oncocyte (2009)
  • Author(s): H. Kimura, MA. Landek-Salgado, K. Suzuki, P. Caturegli
  • Organizer: 9^<th> Asia Oceania Thyroid Association Congress
  • Place of Presentation: Nagoya
• [Presentation] GH産生下垂体腺腫に2次性拡張型心筋症を合併した一例 (2009)
  • Author(s): 須江麻里子、吉原彩、渡邊奈津子、一条貴政、石川真由美、安藤恭代、上芝元、廣井直樹、鈴木幸一、坪井久美子、芳野原
  • Organizer: 第13回日本内分泌病理学会学術総会
  • Place of Presentation: 甲府市
• [Presentation] 免疫プロテアソームによる甲状腺機能と濾胞形態の調節 (2009)
  • Author(s): 木村博昭、Melissa Landek-Salgado、鈴木幸一、Patrizio Caturegli
  • Organizer: 第13回日本内分泌病理学会学術総会
  • Place of Presentation: 甲府市
• [Presentation] マウス腎臓におけるサイログロブリン遺伝子断片の発現と意義 (2009)
  • Author(s): Huhehasi Wu、鈴木さゆり、Donald F. Sellitti、Sonia Q. Doi、赤間剛、相沢清香、川島晃、谷川和也、吉田明雄、加藤良平、鈴木幸一
  • Organizer: 第13回日本内分泌病理学会学術総会
  • Place of Presentation: 甲府市
• [Presentation] 甲状腺細胞傷害によって漏出する二本鎖DNAが誘導する自然免疫機構の解明 (2009)
  • Author(s): 川島晃、谷川和也、Huhehasi Wu、赤間剛、石井則久、武下文彦、鈴木幸一
  • Organizer: 第82回日本内分泌学会
  • Place of Presentation: 前橋
• [Presentation] 甲状腺濾胞形成、濾胞機能調節、細胞増殖研究の新しい展開。-甲状腺腫、自己免疫、機能異常の背景- (2009)
  • Author(s): 鈴木幸一
  • Organizer: 第21回日本内分泌外科学会総会、特別講演2
  • Place of Presentation: 岡山
• [Presentation] Molecular cloning and characterization of a novel thyroglobulin(Tg)variant in mouse kidney (2009)
  • Author(s): Wu H, Suzuki S, Sellitti DF, Doi SQ, Aizawa S, Tanigawa K, Akama T, Kawashima A, Mishima M, Ishii N, Yoshida A, Hisatome I, Koles N, Katoh R, Suzuki K.
  • Organizer: 80th Annual Meeting of The American Thyroid Association
  • Place of Presentation: Palm Beach, Florida
• [Presentation] Infiltrating macrophages induce oncocytic phenotype in thyr-IFNγ transgenic mouse thyroids : A critical role of LMP2 in the pathogenesis of oncocyte (2009)
  • Author(s): Hiroaki Kimura, Melissa A.Landek-Salgado, Koichi Suzuki, Patrizio Caturegli
  • Organizer: 9^<th> Asia Oceania Thyroid Association Congress
  • Place of Presentation: Nagoya
• [Remarks]
  • URL: http://members3.jcom.home.ne.jp/koichis0923/
• [Remarks]
  • URL: http://members3.jcom.home.ne.jp/koichis0923/
• [Remarks]
  • URL: http://members3.jcom.home.ne.jp/koichis0923/