| Project/Area Number |
21591190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
|
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HOSODA Hiroshi 独立行政法人国立循環器病研究センター, 再生医療部, 室長 (40359807)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAZATO Mikiya 独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KANGAWA Kenji 独立行政法人国立循環器病研究センター, 研究所, 部長 (00112417)
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|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | グレリン / 生理活性ペプチド / 神経科学 / 再生医学 / 生理活性 |
|---|
| Research Abstract |
The liver is richly innervated, and the autonomic nervous system regulates hepatic functions, such as hepatic regeneration and apoptosis, and metabolic control. Because ghrelin participates in the central regulation of gastric functions through vagal nerve pathway, we have explored the effect of ghrelin on the neural regulation of hepatic functions. In a rat model of lethal liver cirrhosis produced by dimethylnitrosamine, repeated ghrelin administration reduces the collagen deposition and hepato cyte apoptosis, and accelerates hepatocyte proliferation and normalization of liver function, resulting in the recovery from lethal hepatic failure. Ghrelin also promotes regenerative liver growth in seventy-percent partial hepatectomized rats. Thus, ghrel in may serve as a new neuroendocrinologic approach for improving hepatic functions and accelerating liver regeneration in-patients with liver cirrhosis and hepatic resection.
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