| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
One of the outside cellular regulators are metalloproteinases(MMPs). MMP activation can promote the secretion of hematopoietic growth factors, which in turn drive hematopoietic cell differentiation into e. g. CD11B-positive F4/80 BM-derived cells. These angiopotent cells can be recruited into various tumor beds to further accelerate vasuarization necessary for tumor growth. In addition, these BM-derived cells are major producers of MMPs, creating a vicious cycle accelerating tumor cell growth. In this application, I suggest that proteases can become a novel molecular target in the treatment of blood tumor-related disease treatment including myeloma.
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