| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We identified that the inhibition of glycosylation machinery reduced the cell surface expression of wild type FLT3 and induced cell death through the inhibition of activated STATs in wild type FLT3-expressing cells, but not in mutant FLT3-expressing cells. We demonstrated that the glycosylation is essential for auto-phosphorylation via FL-stimulation in wild type FLT3, and that mutant FLT3 is auto-phosphorylated within the cytoplasm before the glycosylation resulting in the cell proliferation via STATs phosphorylations.
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