Energy metabolism in the growth and differentiation of hematopoietic stem/ progentor cells
| Project/Area Number |
21591202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
EZOE Sachiko 大阪大学, 医学部附属病院, 特任講師(常勤) (90379173)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 大学院・医学系研究科, 教授 (20177489)
MATSUMURA Itaru 大阪大学, 医学系研究科, 准教授 (00294083)
ORITANI Kenji 大阪大学, 大学院・医学系研究科, 准教授 (70324762)
MIZUKI Masao 大阪大学, 医学部附属病院, 准教授 (80283761)
SHIBAYAMA Hirohiko 大阪大学, 大学院・医学系研究科, 講師 (60346202)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 造血幹細胞 / エネルギー代謝 / 骨髄微小環境 / 増殖 / 分化 / Sirt1 / グルコース濃度 / Niche / 未分化性 |
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| Research Abstract |
Recently, it is reported that undifferentiated state of hematopoietic stem cells is regulated by their environmental factors, such as oxygen concentration. In hematopoietic stem/ progenitor cells, the environmental glucose concentration and the intracellular energy metabolism are involved in the maintenance of stemness and the regulation of proliferation.
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Report
(4 results)
Research Products
(34 results)
