Establishment of epigenetic pattern during cell differentiation
Project/Area Number |
21591204
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | 財団法人東京都医学総合研究所 (2011) Tokyo Metropolitan Organization for Medical Research (2009-2010) |
Principal Investigator |
KITAJIMA Kenji 財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (10346132)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 血液内科学 / ES細胞 / 血液細胞 / 転写因子 / 細胞分化 / エピジェネティクス |
Research Abstract |
Using mouse embryonic stem cell differentiation induction system, we investigated the role of GATA-1, required for terminal erythroid differentiation, on establishments of erythroid-specific epigenetic pattern. We found that GATA-1 would establish the erythroid-specific epigenetic pattern during cell fate determination from multipotent hematopoietic progenitor cells into erythroid lienage.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Multiple ETS Family Proteins Regulate PF4 Gene Expression by Binding to the Same ETS Binding Site2011
Author(s)
Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T
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Journal Title
Related Report
Peer Reviewed
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