| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We analyzed gene abnormalities that may play a central role for the pathogenesis in myelodysplastic syndromes(MDS) and acute myeloid leukemias. Gene mutations of hematopoietic transcriptional factors RUNX1, CEBPA and GATA2 have been detected. Moreover, we clarified that the mutants had a potential to develop MDS by using human hematopoietic stem cells and mouse bone marrow transplantation model. Therefore, we proposed that the mutations of RUNX1, CEBPA and GATA2 are the master gene mutations for the pathogenesis of MDS.
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