Molecular analysis of effects of HUB molecules in transcription factor network on cell differentiation
Project/Area Number |
21591208
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Kumamoto University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 細胞分化 / 転写因子 / c-myb / 血液細胞 / 血液幹細胞 / リンパ球 / B細胞 / T細胞 / 骨髄球 |
Research Abstract |
I established a new mouse line reporting the endogenious c-Myb protein level. By using these mice, it was evident that various types of hematopoietic progenitors and stem cells expressed c-Myb, some of which have never been reported before. Also, in hematopoietic stem cell population, c-Myb labeles around 90% of them, which presented futures different form c-Myb positive cells.
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Report
(4 results)
Research Products
(13 results)