Establishment of hematological malignancy mouse model optimized with in vivo imaging.

• Project/Area Number: 21591209
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kumamoto University
• Principal Investigator: OKADA Seiji 熊本大学, エイズ学研究センター, 教授 (50282455)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 高度免疫不全マウス / マウスモデル / 生体イメージング / 血液悪性腫瘍 / NF-κB / 造血幹細胞 / 造血器腫瘍 / 癌 / 動物モデル / 蛍光色素 / 免疫不全マウス

Research Abstract

The aim of this study is the establishment of the novel hairless severe immunodeficient mice optimized for in vivo bio-imaging and murine model of human hematological malignancies. We proved that Diethyldithiocarbamate and berberine had anti-tumor effects via suppression of NF-kappaB pathway using model mice. We established Balb/c Nude Rag-2/Jak3 double deficient mice that is suitable for in vivo imaging.

Research Products

• [Journal Article] HIV-1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule(SLAM) in CD4+T cells (2012)
  • Author(s): Mitsuki Y, Terahara K, Shibusawa K, Yamamoto T, Tsuchiya T, Mizukoshi F, Ishige M, Okada S, Kobayashi K, Morikawa Y, Nakayama T, Takeda M, Yanagi Y, and Tsunetsugu-Yokota Y
  • Journal Title: J Virol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Rb/E2F1 regulate innate immune receptor Toll-like receptor 3 in epithelial cells (2012)
  • Author(s): Taura M, Suico MA, Koyama K, Komatsu K, Miyakita R, Matsumoto C, Kudo E, Kariya R, Goto H, Kitajima S, Takahashi C, Shuto T, Nakao M, * Okada S, and* Kai H
  • Journal Title: Mol Cell Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] HIV-1 Proteins Preferentially Activate Anti-Inflammatory M2-Type Macrophages (2012)
  • Author(s): Chihara T, Hashimoto M, Osman A, Hiyoshi-Yoshidomi Y, Suzu I, Chutiwitoonchai N, Hiyoshi M, Okada S, Suzu S
  • Journal Title: J Immuno Volume: (in press)
  • Peer Reviewed
• [Journal Article] Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis (2012)
  • Author(s): Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Matsuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T, Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, and Oike Y
  • Journal Title: Cancer Res Volume: 72(7) Pages: 1784-1794
  • Peer Reviewed
• [Journal Article] Target-selective photo-degradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids (2012)
  • Author(s): Tanimoto S, Sakai S, Kudo E, Okada S, Matsunuma S, Takahashi D, and* Toshima K
  • Journal Title: Chemistry-An Asian Journal Volume: (in press)
  • Peer Reviewed
• [Journal Article] The antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway (2012)
  • Author(s): Goto H, Kariya R, Shimamoto M, Kudo E, Taura M, Katano H, and* Okada S
  • Journal Title: Cancer Sci Volume: 103(4) Pages: 775-781
  • Peer Reviewed
• [Journal Article] Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP (2012)
  • Author(s): Phimsen S, Kuwahara K, Nakaya T, Ohta K, Suda T, Rezano A, Kitabatake M, Vaeteewoottacharn K, Okada S, Tone S, and* Sakaguchi N
  • Journal Title: Apoptosis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Hmga1 is differentially expressed and mediates transcriptional silencing of the Cd4/Cd8 loci in T cell lineages and leukemic cells (2012)
  • Author(s): Xi Y, Watanabe S, Hino Y, Sakamoto C, Nakatsu Y, Okada S, and Nakao M
  • Journal Title: Cancer Sci Volume: 103(3) Pages: 439-447
  • Peer Reviewed
• [Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor (2012)
  • Author(s): Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H, Kanno M, Miwa M, Okada S, Andreeff M and* Saya H
  • Journal Title: Oncogene Volume: (in press)
  • Peer Reviewed
• [Journal Article] Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway (2012)
  • Author(s): Matsuno T, Kariya R, Yano S, Morino-Koga S, Taura M, Suico MA, Shimauchi Y, Matsuyama S, Okamoto Y, Shuto T, Kai H, and Okada S
  • Journal Title: Int J Oncol Volume: 40(4) Pages: 1071-1078
  • Peer Reviewed
• [Journal Article] Evaluation of a recombinant measles virus as the expression vector of hepatitis C virus envelope proteins (2012)
  • Author(s): Kasama Y, Satoh M, Saito M, Okada S, Kai C, and K* Tsukiyama-Kohara
  • Journal Title: World J Vaccines Volume: (in press)
  • Peer Reviewed
• [Journal Article] Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-_kB pathway. (2012)
  • Author(s): Goto H., et.al.
  • Journal Title: Cancer Science Volume: 103(4) Issue: 4 Pages: 775-781
  • DOI: 10.1111/j.1349-7006.2012.02212.x
  • Peer Reviewed
• [Journal Article] Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-kB pathway (2012)
  • Author(s): Matsuno T, et al
  • Journal Title: International Journal of Oncology Volume: 40 Pages: 1071-1078
  • DOI: 10.3892/ijo.2011.1313
  • Peer Reviewed
• [Journal Article] The Identification of a Small Molecule Compound that Reduces HIV-1 Nef-mediated Viral Infectivity Enhancement (2011)
  • Author(s): Chutiwitoonchai N, Hiyoshi M, Mwimanzi P, Ueno T, Adachi A, Ode H, Sato H, Fackler OT, Okada S, and* Suzu S
  • Journal Title: ProS ONE Volume: 6(11)
  • NAID: 120004058203
  • Peer Reviewed
• [Journal Article] Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis (2011)
  • Author(s): Komizu Y, Yukihara M, Kariya R, Goto K, Okada S and Ueoka R
  • Journal Title: Bioorg Med Chem Lett Volume: 21(13) Pages: 3962-3965
  • Peer Reviewed
• [Journal Article] HIV-1 Nef Perturbs the Function, Structure, and Signaling of the Golgi through the Src Kinase Hck (2011)
  • Author(s): Hiyoshi M, Takahashi-Makise N, Y. Yoshidomi Y, Chutiwitoonchai N, Chihara T, Okada M, Nakamura N, Okada S, and Suzu S
  • Journal Title: J Cell Physiol Volume: 227(3) Pages: 1090-1097
  • Peer Reviewed
• [Journal Article] Comparative study of human hematopoietic cell engraftment into Balb/c and C57BL/6 strain of Rag-2/Jak3 double-deficient mice (2011)
  • Author(s): Ono A, Hattori S, Kariya R, Iwanaga S, Taura M, Harada H, Suzu S, and* Okada S
  • Journal Title: J Biomed Biotechnol Volume: 2011 Pages: 539748-539748
  • Peer Reviewed
• [Journal Article] Bcl6 is required for the development of mouse CD4+and CD8・+dendritic cells (2011)
  • Author(s): Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M, Hatano M, Okada S and* Tokuhisa T
  • Journal Title: J Immunol Volume: 186(1) Pages: 2800-2808
  • Peer Reviewed
• [Journal Article] MEF/ELF4 transactivation by E2F1 is inhibited by p53 (2011)
  • Author(s): Taura M, Suico MA, Fukuda R, Koga T, Shuto T, Sato T, Morino-Koga S, Okada S and Kai H
  • Journal Title: Nucleic Acid Res Volume: 39(1) Pages: 76-88
  • Peer Reviewed
• [Journal Article] Comparative study of human hematopoietic cell engraftment into Balb/c and C57BL/6 strain of Rag-2/Jak3 double-deficient mice. (2011)
  • Author(s): Ono A, et al.
  • Journal Title: J Biomed Biotechnol Volume: 2011 Pages: 539748-539748
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo. (2011)
  • Author(s): Towata T, et al.
  • Journal Title: Leuk Res Volume: 34 Pages: 906-911
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells (2010)
  • Author(s): Shimasaki S, Koga T, Shuto T, Suico M A, Sato T, Watanabe K, Morino-Koga S, Taura M, Okada S, Mori K, and Kai H
  • Journal Title: Biochem Biophys Res Comm Volume: 402(2) Pages: 235-240
  • Peer Reviewed
• [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis (2010)
  • Author(s): Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda S, Suda T, and* Saya H
  • Journal Title: Oncogene Volume: 29(42) Pages: 5687-5699
  • Peer Reviewed
• [Journal Article] 22-oxa-1, 25-dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculutre of Cholangiocarcinoma (2010)
  • Author(s): Seubwai W, Wongkham C, Puapairoj A, * Okada S and* Wongkham S
  • Journal Title: Cancer Volume: 116(23) Pages: 5535-5543
  • Peer Reviewed
• [Journal Article] Circulating CD14+CD16+monocyte levels predict tissue invasive character of cholangiocarcinoma (2010)
  • Author(s): Subimerb C, Lulitanond V, Pinlaor S, Khuntikeo N, Okada S, McGrath M, Wongkham S
  • Journal Title: Clin Exp Immunol Volume: 161(3) Pages: 471-479
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit the growth of Cholangiocarcinoma by induction of cell cycle arrest in G_1 phase (2010)
  • Author(s): Towata T, Komizu Y, Kariya R, Suzu S, Matsumoto Y, Kobayashi N, Wongkham C, Wongkham S, Ueoka R, and Okada S
  • Journal Title: Bioorg Med Chem Lett Volume: 20(12) Pages: 680-3682
  • Peer Reviewed
• [Journal Article] IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation (2010)
  • Author(s): Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M, Motoyoshi K, Kimura F, and Okada S
  • Journal Title: Cell Death Differ Volume: 17(12) Pages: 1917-1927
  • Peer Reviewed
• [Journal Article] Cepharanthine exerts anti-tumor activity on cholangiocarcinoma by inhibiting NF-κB (2010)
  • Author(s): Seubwai W, Vaeteewoottacharn K, Hiyoshi M, Suzu S, Puapairoj A, Wongkham C, Okada S and Wongkham S
  • Journal Title: Cancer Sci Volume: 101(7) Pages: 1590-1595
  • NAID: 10026594375
  • Peer Reviewed
• [Journal Article] Evaluation of a recombinant measles virus expressing hempatitis C virus envelope proteins by infection of human PBMC-NOD/Scid/Jak3^<null> mouse (2010)
  • Author(s): Satoh M, Saito M, Tanaka K, Iwanaga S, Nagla S, Seki T, Okada S, Kohara M, Harada S, Kai C, and Tsukiyama-Kohara K
  • Journal Title: Comp Immunol Microbiol Infect Dis Volume: 33(6)
  • Peer Reviewed
• [Journal Article] Highly selective fusion and accumulation of Hybrid Liposomes into Primary Effusion Lymphoma Cells along with induction of apoptosis (2010)
  • Author(s): Towata T, Komizu Y, Suzu S, Ueoka R, and Okada S
  • Journal Title: Biochem Biophys Res Comm Volume: 393(3) Pages: 445-448
  • Peer Reviewed
• [Journal Article] Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion : Reversion by antiviral treatment (2010)
  • Author(s): Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y, and Okada S.
  • Journal Title: Biochem Biophys Res Comm Volume: 393(2) Pages: 331-337
  • Peer Reviewed
• [Journal Article] Whole Brain radiation alone produces favorable outcomes for AIDS-related primary central nervous system lymphoma in the HAART era (2010)
  • Author(s): Nagai H, Odawara T, Ajisawa A, Hagiwara S, Watanebe T, Uehira T, Uchiumi H, Yotsumoto M, Miyakawa T, Watanabe A, Kanbe T, Konishi M, Saito S, Takahama S, Tateyama M, and Okada S
  • Journal Title: Eur J Haematol Volume: 84(6) Pages: 499-505
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo (2010)
  • Author(s): Towata T, Komizu Y, Suzu S, Matsumoto Y, Ueoka R, and Okada S
  • Journal Title: Leukemia Res Volume: 34(7) Pages: 906-911
  • Peer Reviewed
• [Journal Article] Therapeutic effects ofγ-irradiation in a primary effusion lymphoma mouse model (2010)
  • Author(s): Shiraishi Y, Gotoh K, Towata T, Shimasaki T, Suzu S, Kojima A, and Okada S
  • Journal Title: Exp Therap Med Volume: 1(1) Pages: 79-84
  • Peer Reviewed
• [Journal Article] 22-oxa-1,25-dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculutre of Cholangiocarcinoma. (2010)
  • Author(s): Sebwai W, et al.
  • Journal Title: Cancer Volume: 116 Pages: 5535-5543
  • Peer Reviewed
• [Journal Article] Cepharanthine exerts anti-tumor activity on cholangiocarcinoma by inhibiting NF-κB. (2010)
  • Author(s): Sebwai W, et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 1590-1595
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit the growth of Cholangiocarcinoma by induction of cell cycle arrest in G_1 phase. (2010)
  • Author(s): Towata T, et al.
  • Journal Title: Bioorg Med Chem Lett Volume: 20 Pages: 3680-3682
  • Peer Reviewed
• [Journal Article] Highly selective fusion and accumulation of Hybrid Liposomes into Primary Effusion Lymphoma Cells along with induction of apoptosis (2010)
  • Author(s): Towata T, et al.
  • Journal Title: Biochem Biophys Res Comm 393 Pages: 445-448
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo (2010)
  • Author(s): Towata T, et al.
  • Journal Title: Leukemia Res (印刷中)
  • Peer Reviewed
• [Journal Article] Therapeutic effects of γ-irradiation in a primary effusion lymphoma mouse model (2010)
  • Author(s): Shiraishi Y, et al.
  • Journal Title: Exp Therap Med 1 Pages: 79-84
  • Peer Reviewed
• [Journal Article] Potent activity of a Nucleoside Reverse Transcriptase Inhibitor, 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine, against HIV-1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice (2009)
  • Author(s): Hattori S, Ide K, Nakata H, Harada H, Suzu S, Ashida N, Kohgo S, Hayakawa H, Mitsuya H, and* Okada S
  • Journal Title: Antimicrob Agents Chemother Volume: 53(9) Pages: 3887-3893
  • Peer Reviewed
• [Journal Article] Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms (2009)
  • Author(s): Hassan R, Suzu S, Hiyoshi M, Takahashi-Makise N, Ueno T, Agatsuma T, Akari H, Komano J, Takebe Y, Motoyoshi K, and* Okada S
  • Journal Title: J Cell Physiol Volume: 221(2) Pages: 458-468
  • Peer Reviewed
• [Journal Article] Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NK-κB pathway (2009)
  • Author(s): Takahashi-Makise N, Suzu S, Hiyoshi M, Ohsugi T, Katano H, Umezawa K, and Okada S
  • Journal Title: Int J Cancer Volume: 125(6) Pages: 1464-1472
  • Peer Reviewed
• [Presentation] HIV感染症と血液悪性腫瘍 (2011)
  • Author(s): 岡田誠治
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京
• [Presentation] NOD/SCID/Jak3-/-マウスを用いたヒトNK細胞モデルマウスの構築及びHIV-1感染 (2011)
  • Author(s): 服部真一朗、刈谷龍昇、Pattaravadee Srikoon、松田幸樹、岡田誠治
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京
• [Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミックスと抗HIV-1剤によるその変容の検討-1 (2011)
  • Author(s): 青木宏美、鍬田伸好、服部真一朗、林宏典、青木学、岡田誠治、満屋裕明
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京、
• [Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミックスと抗HIV-1剤によるその変容の検討-2 (2011)
  • Author(s): 鍬田伸好、青木宏美、服部真一朗、林宏典、青木学、中村太平、岡田誠治、満屋裕明
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京
• [Presentation] 本邦おけるエイズ関連ホジキンリンパ腫19例の実態 (2011)
  • Author(s): 四本美保子、味澤篤、萩原將太郎、田沼順子、上平朝子、永井宏和、藤川裕子、北野喜良、有馬靖佳、宇野健司、岩井俊樹、本郷偉元、岡田誠治
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京
• [Presentation] フラーレン誘導体によるHIV-1増殖抑制効果 (2011)
  • Author(s): 工藤恵理子、谷本周穂、田浦学、高橋大介、戸嶋一敦、岡田誠治
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京
• [Presentation] R5及びX4 HIV-1同時感染ヒト化マウスモデルによる感染早期のウィルス優位性の解析 (2011)
  • Author(s): 石下真行、寺原和孝、渋沢謙太郎、光木裕也、池野翔太、小林和夫、岡田誠治、横田(恒次)恭子
  • Organizer: 第25回日本エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京、東京
• [Presentation] Rb regulates Toll-like receptor 3 expression and function in epithelial cells (2011)
  • Author(s): Manabu Taura, Mary Ann Suico, Hirofumi Kai, and Seiji Okada
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ、千葉
• [Presentation] Dual NK activities of CD56dimCD16-NK cells in cord blood and pheriphery : the significant minor subpopulation associated with NK defects in HIV-1 infection (2011)
  • Author(s): Pattaravadee Srikoon, Manthnana Michai, and Seiji Okada
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ、千葉
• [Presentation] GANP is required for prevention of NDA damage and cell apoptosis (2011)
  • Author(s): Suchada Phimsen, Kazuhiko Kuwahara, Seiji Okada and Nobuo Sakaguchi
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ、千葉
• [Presentation] The antitumot effect of berberine against primary effusion lymphoma via inhibition of NF-kappaB (2011)
  • Author(s): Hiroki Goto, Ryusho Kariya, Masako Shimamoto, Eriko Kudo, Koki Matsuda, Shinichiro Hattori, Manabu Taura, Koichi Hamada, Harutaka Katano, and Seiji Okada
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] Non-AIDS-defining hematological malignancies in HIV-infected patients : an epidemiological study (2011)
  • Author(s): Shotaro Hagiwara and Seiji Okada
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] HIV-1感染におけるCD4+Foxp3+T細胞の動態および感染性の検討 (2011)
  • Author(s): 服部真一朗、淵上典子、刈谷龍昇、鈴伸也、岡田誠治
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都市国際交流会館、京都
• [Presentation] CepharanthineはHIVの侵入を阻害することで、感染を抑制する (2011)
  • Author(s): 松田幸樹、服部真一朗、刈谷龍昇、嶋本雅子、濱田浩一、岡田誠治
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都市国際交流会館、京都
• [Presentation] The antitumot effect of berberine against primary effusion lymphomavia inhibition of NF-kappaB (2011)
  • Author(s): Hiroki Goto, et al
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Fluctuation in the mechanism of HIV protease inhibitors between HIV protease and proteasome (2010)
  • Author(s): Ryusho Kariya, Manabu Taura, Masako Shimamoto, Shinya Suzu, Hiroumi Kai, Harutaka Katano and Seiji Okada
  • Organizer: The 4th International Symposium. Molecular Science of Fluctuations toward Biological Functions
  • Place of Presentation: Piaza Omi, Shiga, Japan
• [Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミックスの検討: 1 (2010)
  • Author(s): 鍬田伸好、青木宏美、服部真一朗、中村太平、青木学、前田賢次、岡田誠治、満屋裕明
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: グランドプリンスホテル高輪、東京
• [Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミックスの検討: 2 (2010)
  • Author(s): 青木宏美、鍬田伸好、服部真一朗、中村太平、青木学、前田賢次、岡田誠治、満屋裕明
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: グランドプリンスホテル高輪、東京
• [Presentation] エイズ関連悪性リンパ腫におけるmiRNAの発現異常とシグナル伝達系に与える影響 (2010)
  • Author(s): 山岸誠、三宅在子、中野和民、片野晴隆、岡田誠治、渡邊敏樹
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: グランドプリンスホテル高輪、東京
• [Presentation] HIV-1感染における制御性T細胞の動態解析 (2010)
  • Author(s): 服部真一朗、淵上典子、鈴伸也、岡田誠治
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: グランドプリンスホテル高輪、東京
• [Presentation] 本邦における悪性リンパ腫の現状と課題 (2010)
  • Author(s): 岡田誠治
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: グランドプリンスホテル高輪、東京
• [Presentation] HIV-1感染モデルとしてのヒト化マウスの妥当性とX4及びR5 HIV-1感染 (2010)
  • Author(s): 石下真行、寺原和孝、光木裕也、渋沢謙太郎、小林和夫、岡田誠治、横田(恒次)京子
  • Organizer: 第58回日本ウィルス学会学術集会
  • Place of Presentation: あわぎんホール、徳島
• [Presentation] HIV protease inhibitor inhibits the growth of primary effusion lymphoma and induces apoptosis (2010)
  • Author(s): Ryusho Kariya, Manabu Taura, Shinya Suzu, and Seiji Okada
  • Organizer: 第72回日本血液学会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] HIV protease inhibitor inhibits the growth of primary effusion lymphoma and induces apoptosis. (2010)
  • Author(s): Ryusho Kariya, et al
  • Organizer: 第72回日本血液学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] HIV-1 Nef機能標的化合物の同定と阻害機序 (2009)
  • Author(s): 鈴伸也、日吉真照、Ranya Hassan、Nopporn Chutiwitoonchai、岡田誠治
  • Organizer: 第57回日本ウィルス学会
  • Place of Presentation: 都市センターホテル、東京
  • Year and Date: 2009-10-25
• [Presentation] M-CSFと受容体Fmsを共有するサイトカインIL-34の機能解析 (2009)
  • Author(s): 千原隆、鈴伸也、岡田誠治
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2009-10-24
• [Presentation] マクロファージ特異的宿主因子を介したHIV-1 Nefの機能 (2009)
  • Author(s): 鈴伸也、日吉真照、Ranya Hassan、Nopporn Chutiwitoonchai、岡田誠治
  • Organizer: 第23回日本エイズ学会学術集会総会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] HIV-1感染細胞の体内播種とin vivo imaging(1) (2009)
  • Author(s): 青木宏美, 鍬田伸好, 中村太平, 服部真一朗, 岡田誠治, 満屋裕明
  • Organizer: 第23回日本エイズ学会学術集会総会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] HIV-1感染細胞の体内播種とin vivo imaging(2) (2009)
  • Author(s): 鍬田伸好, 青木宏美, 中村太平, 服部真一朗, 岡田誠治, 満屋裕明
  • Organizer: 第23回日本エイズ学会学術集会総会
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Presentation] エイズ関連悪性リンパ腫 (2009)
  • Author(s): 岡田誠治
  • Organizer: 第23回日本エイズ学会シンポジウム5.「HIV-1感染と悪性腫瘍」
  • Place of Presentation: 名古屋国際会議場、名古屋
• [Remarks]
  • URL: http://www.caids.kumamoto-u.ac.jp/data/okada/default.html
• [Remarks]
  • URL: http://www.caids.kumamoto-u.ac.jp/data/okada/default.html
• [Remarks]
  • URL: http://www.caids.kumamoto-u.ac.jp/data/okada/default.html
• [Patent(Industrial Property Rights)] ヒト化マウス (2012)
  • Inventor(s): 山村研一、荒木喜美、岡田誠治、下野明彦
  • Industrial Property Rights Holder: 熊本大学、トランスジェニック
  • Filing Date: 2012-03-24
  • Overseas
• [Patent(Industrial Property Rights)] 生体イメージングに最適化された高度免疫不全マウス (2010)
  • Inventor(s): 岡田誠治
  • Industrial Property Rights Holder: 熊本大学
  • Industrial Property Number: 2010-118452
  • Filing Date: 2010-05-24