| Project/Area Number |
21591216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Miyagi University (2010-2011)
Sendai University (2009) |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takahumi 東北大学, 医学系研究科, 助教 (70508308)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 転写因子 / 造血幹細胞 / 酸化ストレス / 転写制御 / 細胞周期 / 癌化 / 活性酸素 / 細胞の老化 |
|---|
| Research Abstract |
Long-term dormancy in proliferation and strong defense response against oxidative stresses, prevent the senescence and tumorigenesis of hematopoietic stem cells. Here, we show that GATA2, a transcription factor essential for the life-long maintenance of hematopoietic stem cells, directly activates the transcription of several genes regulating cell proliferation, as well as genes regulating oxidative status. Furthermore, mice deficient in transcription factor Nrf2, which inclusively regulates oxidative stress response genes, show the different kinetics of hematopoietic stem/progenitor cells from wild type mice. These results indicate that cell proliferation and defense against oxidative stresses have shared regulatory components in hematopoietic stem cells.
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