| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Leukemias are clonal disorders of hematopoietic stem cells or immature progenitors. However, a simple comparison of the bone marrow(BM) mononuclear cells(MNCs) among heterogeneous acute myeloid leukemia(AML) patients is likely to reveal a large number of changes in the genome that reflect differences either in the percentage of blasts within BM, or in the differentiation ability of the blasts. To minimize such population-shift effects, we have set up a large-scale cell bank(the Blast Bank) for the storage of hematopoietic stem cell(HSC)-like fractions purified from individuals with a wide range of leukemic disorders. To identify oncogenes in leukemias, and to clarify a molecular signature that was directly linked to the prognosis of leukemic patients, we performed a large-scale genomic analysis of the Blast Bank specimens.
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