The Role of Reactive Oxygen Species In Apoptosis Induction of Mantle Cell Lymphoma(MCL); Inhibition of NADPH Oxidase 2 Induces Apoptosis In MCL

• Project/Area Number: 21591226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Aichi Medical University
• Principal Investigator: MIURA Yuji 愛知医科大学, 看護学部, 教授 (00345612)
• Co-Investigator(Kenkyū-buntansha): MIWA Hroshi 愛知医科大学, 医学部, 教授 (00209967)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 悪性リンパ腫 / ストローマ / 薬剤耐性

Research Abstract

Mantle cell lymphoma(MCL) is an aggressive tumor and is characterized by deregulated growth and resistance to apoptosis. Reactive oxygen species(ROS) are important signal transduction molecules in regulation of MCL cell growth, differentiation and apoptosis. ROS generated by Nox2, at least in part, transmit cell survival signals through the AKT-ASK1 pathway in MCL cells and their depletion leads to apoptosis.

Research Products

• [Journal Article] The Role of Reactive Oxygen Species In Apoptosis Induction of Mantle Cell Lymphoma(MCL) (2010)
  • Author(s): Yuji Miura, Hiroshi Miwa, Toshihito Ohno, Miyako Haneda, Yoshitaka Hosokawa, Masakazu Nitta, and Masanori Daibata
  • Journal Title: Inhibition of NADPH Oxidase 2 Induces Apoptosis In MCL. Blood Volume: 116 Pages: 3616-3616
• [Presentation] The Role of Reactive Oxygen Species in Apoptosis Induction of Mantle Cell Lymphoma(MCL); Inhibition of NADPH Oxidase 2 Induces Apoptosis in MCL (2010)
  • Author(s): Yuji Miura, Hiroshi Miwa, Toshihito Ohno, Miyako Haneda, Yoshitaka Hosokawa, Masakazu Nitta, Masanori Daibata
  • Organizer: 第52回米国血液学会年次総会
  • Place of Presentation: 米国フロリダ州オーランド
  • Year and Date: 2010-12-06
• [Presentation] The Role of Reactive Oxygen Species in Apoptosis Induction of Mantle Cell Lymphoma (MCL) ; Inhibition of NADPH Oxidase 2 Induces Apoptosis in MCL (2010)
  • Author(s): Yuji Miura, Hiroshi Miwa, Toshihito Ohno, Miyako Haneda, Yoshitaka Hosokawa, Masakazu Nitta, Masanori Daibata
  • Organizer: 第52回米国血液学会年次総会
  • Place of Presentation: オーランド(フロリダ州)
  • Year and Date: 2010-12-06
• [Presentation] 遺伝子の異常によって起こる病気,がん (2009)
  • Author(s): 三浦裕次
  • Organizer: 平成21年度愛知医科大学公開講座
  • Place of Presentation: 愛知医科大学(愛知県)
  • Year and Date: 2009-09-12
• [Presentation] 遺伝子の異常によって起こる病気, がん (2009)
  • Author(s): 三浦裕次
  • Organizer: 平成21年度愛知医科大学公開講座
  • Place of Presentation: 愛知医科大学(愛知県)
  • Year and Date: 2009-09-12