Functional differences between malignant niche on the process of leukemia/lymphoma progression and hematopoietic stem cell niche on the process of cord blood graft engraftment

• Project/Area Number: 21591234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: TAKAHASHI Satoshi 東京大学, 医科学研究所, 准教授 (60226834)
• Co-Investigator(Kenkyū-buntansha): HATTORI Koichi 東京大学, 医科学研究所, 特任准教授 (10360116)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Nobukazu 東京大学, 医科学研究所, 特任准教授 (10334278) ; OOI Jun 東京大学, 医科学研究所, 助教 (20302606)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 造血幹細胞移植学 / 臍帯血移植 / マトリックスメタロプロテイナーゼ(MMP)造血ニッチ / 血液凝固系 / 線維素溶解系 / プラスミン阻害剤 / 血液線維素溶解系 / マトリックスメタロプロテイナーゼ / プラスミン / ニッチ細胞 / Kit-ligand / VEGF / プロセシング / 細胞動員 / GVHD / 炎症性サイトカイン / 繊維素溶解系 / マトリックスメタプロテアーゼ(MMP) / MMP阻害剤 / 同種移植 / 骨髄移植 / 末梢血幹細胞移植 / サイトカイン

Research Abstract

Malignant niche plays a key role for leukemia/lymphoma progression. The main fibrinolytic enzyme, Plasmin(Plm), can activate matrix metalloproteinases and promotes ectodomain shedding of hematopoietic growth factors and mobilization of monomyelocytic lineage cell which can supply angiogenic factors into tumor tissue. This study suggested a new role of protease, like MMP or Plm, in the pathogenesis of leukemia/lymphoma and possibilities of these proteases as new targets of novel molecular therapy.

Research Products

• [Journal Article] Secondary solid tumors after allogeneic hematopoietic SCT in Japan (2012)
  • Author(s): Yokota A, Ozawa S, Masanori T, Akiyama H, Ohshima K, Kanda Y, Takahashi S, Mori T, Nakaseko C, Onoda M, Kishi K, Doki N, Aotsuka N, Kanamori H, Maruta A, Sakamaki H, Okamoto S
  • Journal Title: Bone Marrow Transplant Volume: 47(1) Issue: 1 Pages: 95-100
  • DOI: 10.1038/bmt.2011.23
• [Journal Article] 造血幹細胞動態と血管新生制御機構、診断と治療社 (2012)
  • Author(s): 服部浩一、佐藤亜紀
  • Journal Title: 血管再生治療 Pages: 38-45
• [Journal Article] Feasibility of Reduced-intensity Cord Blood Transplantation as Salvage Therapy for Graft Failure : Results of a Nationwide Survey of 80 Adult Patients (2012)
  • Author(s): Waki F, Takahashi S, et al.
  • Journal Title: Biol Blood Marrow Transplant Volume: 17(6) Pages: 841-51
  • Peer Reviewed
• [Journal Article] Allogeneic cord blood transplantation for adult acute lymphoblastic leukemia : retrospective survey involving 256 patients in Japan (2012)
  • Author(s): Matsumura T, Takahashi S, et al
  • Journal Title: Leukemia Volume: 17(Epub ahead of print) Issue: 7 Pages: 1482-1486
  • DOI: 10.1038/leu.2012.11
  • Peer Reviewed
• [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning regimen in adolescent and young adult patients with hematologic malignancies : a single institute analysis (2012)
  • Author(s): Ebihara Y, Takahashi S, et al
  • Journal Title: Leuk Res Volume: 36(2) Pages: 128-31
  • Peer Reviewed
• [Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment (2012)
  • Author(s): Ishihara M, Heissig B, Nishida C, Rosenkvist J, Tashiro Y, Ohki M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Hattori K
  • Journal Title: Leukemia Volume: 26 Issue: 2 Pages: 332-339
  • DOI: 10.1038/leu.2011.203
  • Peer Reviewed
• [Journal Article] Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis (2012)
  • Author(s): Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H
  • Journal Title: Experimental hematology Volume: 40 Issue: 2 Pages: 143-154
  • DOI: 10.1016/j.exphem.2011.10.008
  • Peer Reviewed
• [Journal Article] New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis (2012)
  • Author(s): Beate Heissig, Makiko Ohki-Koizumi, Yoshihiko Tashiro, Ismael Gritli, Kaori Sato-Kusubata and Koichi Hattori
  • Journal Title: International Journal of Hematology Volume: 95 Issue: 2 Pages: 131-137
  • DOI: 10.1007/s12185-012-1016-y
  • NAID: 10030267151
  • Peer Reviewed
• [Journal Article] Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia (2011)
  • Author(s): Atsuta Y, Morishima Y, Suzuki R, Nagamura-Inoue T, Taniguchi S, Takahashi S, Kai S, Sakamaki H, Kouzai Y, Kobayashi N, Fukuda T, Azuma H, Takanashi M, Mori T, Tsuchida M, Kawase T, Kawa K, Kodera Y, Kato S
  • Journal Title: Biol Blood Marrow Transplant
• [Journal Article] Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation (2011)
  • Author(s): Nakaseko C, Ozawa S, Sakaida E, Sakai M, Kanda Y, Oshima K, Kurokawa M, Takahashi S, Ooi J, Shimizu T, Yokota A, Yoshiba F, Fujimaki K, Kanamori H, Sakai R, Saitoh T, Sakura T, Maruta A, Sakamaki H, Okamoto S
  • Journal Title: Int J Hematol Volume: 93(3) Pages: 375-82
  • NAID: 10029534020
• [Journal Article] Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population (2011)
  • Author(s): Tanabe T, Yamaguchi N, Matsuda K, Yamazaki K, Takahashi S, Tojo A, Onizuka M, Eishi Y, Akiyama H, Ishikawa J, Mori T, Hara M, Koike K, Kawa K, Kawase T, Morishima Y, Amano H, Kobayashi-Miura M, Kakamu T, Nakamura Y, Asano S, Fujita Y
  • Journal Title: Int J Hematol Volume: 93(6) Pages: 771-8
  • NAID: 10029535596
• [Journal Article] A decision analysis of allogeneic hematopoietic stem cell transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched sibling donor (2011)
  • Author(s): Kako S, Morita S, Sakamaki H, Ogawa H, Fukuda T, Takahashi S, Kanamori H, Onizuka M, Iwato K, Suzuki R, Atsuta Y, Kyo T, Sakura T, Jinnai I, Takeuchi J, Miyazaki Y, Miyawaki S, Ohnishi K, Naoe T, Kanda Y
  • Journal Title: Leukemia Volume: 25 Pages: 259-65
• [Journal Article] Feasibility of Reduced-intensity Cord Blood Transplantation as Salvage Therapy for Graft Failure : Results of a Nationwide Survey of 80 Adult Patients (2011)
  • Author(s): Waki F, Masuoka K, Fukuda T, Kanda Y, Nakamae M, Yakushijin K, Togami K, Nishiwaki K, Ueda Y, Kawano F, Kasai M, Nagafuji K, Hagihara M, Hatanaka K, Taniwaki M, Maeda Y, Shirafuji N, Mori T, Utsunomiya A, Eto T, Nakagawa H, Murata M, Uchida T, Iida H, Yakushiji K, Yamashita T, Wake A, Takahashi S, Takaue Y, Taniguchi S
  • Journal Title: Biol Blood Marrow Transplant Volume: 17(6) Pages: 841-51
• [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes (2011)
  • Author(s): Sato A, Ooi J, Takahashi S, Tsukada N, Kato S, Kawakita T, Yagyu T, Nagamura F, Iseki T, Tojo A, Asano S
  • Journal Title: Bone Marrow Transplant Volume: 46(2) Pages: 257-61
• [Journal Article] Tumor necrosis receptor-associated factor(Traf) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease (2011)
  • Author(s): Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H
  • Journal Title: J Biol Chem Volume: 151 Pages: 17879-17888
• [Journal Article] 再生不良性貧血における同種造血幹細胞移植の位置づけ (2011)
  • Author(s): 河北敏郎、高橋聡
  • Journal Title: 特集/骨髄不全診療の新しい展開、血液内科 Volume: 63 Pages: 172-178
• [Journal Article] 2. G-CSFのエビデンス2)医科研の臍帯血移植における細菌感染症に対する管理[診療のコツ].症例とエビデンスに学ぶ造血細胞移植と感染症 (2011)
  • Author(s): 加藤せい子、高橋聡
  • Journal Title: 医薬ジャーナル社 Pages: 217-219
• [Journal Article] 臍帯血移植～最近の動向～、特集/造血幹細胞移植の新たな展開 (2011)
  • Author(s): 高橋聡
  • Journal Title: 血液フロンティア Volume: 21 Pages: 21-30
• [Journal Article] 線溶系を起点とした造血制御機構、医薬ジャーナル社 (2011)
  • Author(s): 服部浩一、西田知恵美
  • Journal Title: 血液フロンティア Volume: vol21 Pages: 57-64
• [Journal Article] 凝固・線溶系活性調整による血管新生制御機構、メディカルレビュー社 (2011)
  • Author(s): 服部浩一、佐藤亜紀
  • Journal Title: 血管医学 Volume: Vol12 Pages: 65-70
• [Journal Article] 血液線維素溶解系因子による骨髄細胞の動態制御中外医学社 (2011)
  • Author(s): 服部浩一、西田知恵美
  • Journal Title: 血液 Pages: 187-195
• [Journal Article] Tumor necrosis factor receptor-associated factor (Traf)2 controls homeost Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes (2011)
  • Author(s): Sato A, Takahashi S, et al.
  • Journal Title: Bone Marrow Transplant Volume: 46(2) Pages: 257-61
  • Peer Reviewed
• [Journal Article] Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia (2011)
  • Author(s): Atsuta Y, Takahashi S, et al
  • Journal Title: Biol Blood Marrow Transplant Volume: 18 Pages: 780-787
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor receptor-associated factor (Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease (2011)
  • Author(s): Jiang-Hu Piao
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Issue: 20 Pages: 17879-17888
  • DOI: 10.1074/jbc.p111.221853
  • Peer Reviewed
• [Journal Article] A decision analysis of allogeneic hematopoietic stem cell transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched Ksibline donor. (2011)
  • Author(s): Kako S, Takahashi S, et al.
  • Journal Title: Leukemia. Volume: 25 Pages: 259-65
  • Peer Reviewed
• [Journal Article] Kanto Study Group for Cell Therapy. Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosome-positive leukemia (2010)
  • Author(s): Nakasone H, Kanda Y, Takasaki H, Nakaseko C, Sakura T, Fujisawa S, Yokota A, Yano S, Usuki K, Maruta A, Abe D, Hoshino T, Takahashi S, Kanamori H, Okamoto S
  • Journal Title: Leukemia Volume: 24(6) Pages: 1236-9
• [Journal Article] Adipocyte-Derived Microvesicles Are Associated with Multiple Angiogenic Factors and Induce Angiogenesis in Vivo and inVitro (2010)
  • Author(s): Aoki N., Yokoyama R., Asai N., Ohki M., Ohki Y., Kusubata K., Heissig B., Hattori K., Nakagawa Y., and Matsuda T.
  • Journal Title: Endocrinology Volume: 151 Pages: 2567-2576
• [Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration (2010)
  • Author(s): Heissig B, Nishida C, Tashiro Y, Sato Y, Ishihara M, Ohki M, Hattori K
  • Journal Title: Histology & Histopathology Volume: 25 Pages: 765-770
• [Journal Article] Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration (2010)
  • Author(s): Ohki M, Ohki Y, Ishihara M, Rosenkvist J, Gritli I, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K
  • Journal Title: Blood Volume: 115 Pages: 4302-4312
• [Journal Article] 7. MDSに対する造血細胞移植:適応の拡大と前処置・ドナーソースに関する最近の知見、特集/骨髄異形成症候群(MDS)-病態の解明と克服に向けた進歩 (2010)
  • Author(s): 高橋聡
  • Journal Title: 血液・腫瘍科 Volume: 61 Pages: 672-677
• [Journal Article] 骨髄異形成と造血微小環境の異常Dysfunction of bone marrow microenvironment in myelodysplasia (2010)
  • Author(s): 服部浩一、佐藤亜紀
  • Journal Title: 血液・腫瘍科科学評論社 Volume: 61 Pages: 660-666
• [Journal Article] 造血幹細胞ニッチにおけるMMP-9の役割 (2010)
  • Author(s): 服部浩一、田代良彦
  • Journal Title: 生化学 Volume: 第82巻第10号 Pages: 979-984
  • NAID: 10027502926
• [Journal Article] 線維素溶解系による造血幹細胞ニッチの制御機構 (2010)
  • Author(s): 服部浩一, 西田知恵美
  • Journal Title: 日本血栓止血学会雑誌 Volume: 21 Pages: 27-31
  • NAID: 10026118530
• [Journal Article] Feasibility of Reduced-intensity Cord Blood Transplantation as Salvage Therapy for Graft Failure : Results of a Nationwide Survey of 80 Adult Patients.. (2010)
  • Author(s): Waki F,, Takahashi S, et al
  • Journal Title: Biol Blood Marrow Transplant. Volume: Sep 14.
  • Peer Reviewed
• [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes.. (2010)
  • Author(s): Sato A, Takahashi S, et al.
  • Journal Title: Bone Marrow Transplant. Volume: Apr 19
  • Peer Reviewed
• [Journal Article] Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosome-positive leukemia. (2010)
  • Author(s): Nakasone H, Takahashi S, et al.
  • Journal Title: Leukemia. Volume: 24 Pages: 1236-9
  • Peer Reviewed
• [Journal Article] Tissue type plasminogen activator regulates myeloid-cell dependent neoangiog enesis during tissue regeneration. (2010)
  • Author(s): Ohki M, Hattori K., et al.
  • Journal Title: Blood Volume: 115 Pages: 4302-4312
  • Peer Reviewed
• [Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration. (2010)
  • Author(s): Heissig B. Hattori K., et al.
  • Journal Title: Histology & Histopathology Volume: 25 Pages: 765-770
  • Peer Reviewed
• [Journal Article] Kanto Study Group of Cell Therapy. Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma (2009)
  • Author(s): Nakasone H, Kanda Y, Ueda T, Matsumoto K, Shimizu N, Minami J, Sakai R, Hagihara M, Yokota A, Oshima K, Tsukada Y, Tachibana T, Nakaseko C, Fujisawa S, Yano S, Fujita H, Takahashi S, Kanamori H, Okamoto S
  • Journal Title: Am J Hematol Volume: 84(12) Pages: 809-14
• [Journal Article] Myeloablative unrelated cord blood transplantation for acute leukemia patients between 50 and 55 years of age : single institutional retrospective comparison with patients younger than 50 years of age (2009)
  • Author(s): Konuma T, Takahashi S, Ooi J, Tomonari A, Tsukada N, Kato S, Sato A, Monma F, Kasahara S, Nagamura-Inoue T, Uchimaru K, Iseki T, Tojo A, Yamaguchi T, Asano S
  • Journal Title: Annals of Hematology Volume: 88(6) Pages: 581-8
• [Journal Article] Second myeloablative allogeneic stem cell transplantation(SCT) using cord blood for leukemia relapsed after initial allogeneic SCT (2009)
  • Author(s): Konuma T, Ooi J, Takahashi S, Tomonari A, Tsukada N, Kato S, Sato A, Monma F, Kasahara S, Uchimaru K, Iseki T, Tojo A, Asano S
  • Journal Title: Leuk Res Volume: 33(6) Pages: 840-2
• [Journal Article] Incidence and Risk Factors of Early Bacterial Infections after Unrelated Cord Blood Transplantation (2009)
  • Author(s): Yazaki S, Atsuta Y, Kato K, Kato S, Taniguchi S, Takahashi S, Ogawa H, Kouzai Y, Kobayashi T, Inoue M, Kobayashi R, Nagamura-Inoue T, Azuma H, Takanashi M, Kai S, Nakabayashi M, Saito H
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 15(4) Pages: 439-46
• [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning in adults with ALL (2009)
  • Author(s): Ooi J, Takahashi S, Tomonari A, Tsukada N, Konuma T, Kato S, Kasahara S, Sato A, Monma F, Nagamura F, Iseki T, Tojo A, Asano S
  • Journal Title: Bone Marrow Transplant Volume: 43(6) Pages: 455-9
• [Journal Article] Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia : t(8 ; 21) and inv(16) represent different clinical outcomes (2009)
  • Author(s): Kuwatsuka Y, Miyamura K, Suzuki R, Kasai M, Maruta A, Ogawa H, Tanosaki R, Takahashi S, Koda K, Yago K, Atsuta Y, Yoshida T, Sakamaki H, and Kodera Y
  • Journal Title: Blood Volume: 113 Pages: 2096-2103
• [Journal Article] Disease-specific analyses of unrelated cord blood transplant compared with unrelated bone marrow transplant in adult patients with acute leukemia (2009)
  • Author(s): Atsuta Y, Suzuki R, Nagamura-Inoue T, Taniguchi S, Takahashi S, Kai S, Sakamaki H, Kouzai Y, Kasai M, Fukuda T, Azuma H, Takanashi M, Okamoto S, Tsuchida M, Kawa K, Morishima Y, Kodera Y, and Kato S
  • Journal Title: Blood Volume: 113(8) Pages: 1631-8
• [Journal Article] Contribution of the Fibrinolytic Pathway to Hematopoietic Regeneration (2009)
  • Author(s): Heissig B, Ohki M, Ishihara M, Tashiro Y, Nishida C, Gritli I, Rosenkvist J, Hattori K
  • Journal Title: Journal of Cell Physiology Volume: 221(3) Pages: 51-5
• [Journal Article] Targeted deletion of matrix metalloproteinase-9 reduces neutrophil accumulation during G-CSF-induced neoangiogenesis (2009)
  • Author(s): Sato Y, Ohki Y, Akiyama H, Rosenkvist J, Gritli I, Okumura K, Ogawa H, Heissig B, Hattori K, Ohsaka A
  • Journal Title: Cytometry Res Volume: 19(2) Pages: 53-62
  • NAID: 10026084473
• [Journal Article] 臍帯血ユニット選択基準.ガイドラインパースペクティブ造血幹細胞移植 (2009)
  • Author(s): 高橋聡
  • Journal Title: 医薬ジャーナル社 Pages: 28-38
• [Journal Article] 移植前治療の毒性対策(放射線治療も含めて) (2009)
  • Author(s): 小沼貴晶、高橋聡
  • Journal Title: 白血病治療マニュアル Pages: 231-237
• [Journal Article] MT1-MMPとRECKはヒトCD34陽性造血前駆細胞の定着,放出,動員に関与する (2009)
  • Author(s): 服部浩一, 西田知恵美
  • Journal Title: 分子細胞治療 Volume: 8 Pages: 74-75
• [Journal Article] Heissig Beate :癌増殖過程における骨髄由来細胞と微小環境とのクロストーク (2009)
  • Author(s): 服部浩一, 石原誠人, 西田知恵美
  • Journal Title: 実験医学増刊.癌と微小環境 Volume: 27 Pages: 143-148
• [Journal Article] Heissig Beate:骨髄由来細胞による癌転移及び血管新生ニッチの形成機構 (2009)
  • Author(s): 服部浩一, 田代良彦
  • Journal Title: 血管医学 Volume: 10 Pages: 341-347
• [Journal Article] Second myeloablative allogeneic stem cell transplantation(SCT)using cord blood for leukemia relapsed after initial allogeneic SCT. (2009)
  • Author(s): Konuma T, Ooi J, Takahashi S, et al.
  • Journal Title: Leuk Res. 33 Pages: 840-842
  • Peer Reviewed
• [Journal Article] Myeloablative unrelated cord blood transplantation for acute leukemia patients between 50 and 55years of age : single institutional retrospective comparison with patients younger than 50years of age (2009)
  • Author(s): Konuma T, Ooi J, Takahashi S, et al.
  • Journal Title: Ann Hematol 88 Pages: 581-588
  • Peer Reviewed
• [Journal Article] Contribution of the fibrinolytic pathway to hematopoietic regeneration. (2009)
  • Author(s): Heissig B, Hattori K., et al.
  • Journal Title: J Cell Physiol. 221 Pages: 521-525
  • Peer Reviewed
• [Presentation] Matched HLA Haplotype Contributes to Reduce Sever Acute GVHD with Conserving GVL Effect in HLA-Mismatched Cord Blood Transplantation (2011)
  • Author(s): Takahashi S, et al
  • Organizer: 第53回アメリカ国際血液学会(ASH)
  • Place of Presentation: 米国サンディエゴ市
  • Year and Date: 2011-12-10
• [Presentation] Plasmin inhibition reduces lymphoid tumor growth in mice by suppressing matrix metalloproteinase-9 dependent myeloid cell recruitment (2011)
  • Author(s): Beate Heissig, Hattori K
  • Organizer: 第4回疾患モデルシンポジウム-がん研究のモデル動物-
  • Place of Presentation: 癌研究会癌研究所吉田富三記念講堂(東京都)(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] A role for niches in hematopoietic cell development (2011)
  • Author(s): Beate Heissig, Hattori K
  • Organizer: 第772回千葉県がんセンター研究局集団会
  • Place of Presentation: 千葉県がんセンター(千葉県)(招待講演)
  • Year and Date: 2011-10-19
• [Presentation] 生体内組織再生における線維素溶解系因子PAI-1の機能解明 (2011)
  • Author(s): 田代良彦、西田知恵美、イスマイルグリツリ、小泉摩希子、佐藤弥生、ハイジッヒ・ベアテ、服部浩一
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場、名古屋市
  • Year and Date: 2011-10-16
• [Presentation] Cord blood transplantation in myeloid neoplasm (2011)
  • Author(s): 高橋聡
  • Organizer: JSH-EHA合同シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] 血液線維素溶解系因子による造血系細胞の動態制御機構 (2011)
  • Author(s): 服部浩一
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場、名古屋市
  • Year and Date: 2011-10-15
• [Presentation] MT1-MMP plays a critical role in the modulation of hematopoiesis. (2011)
  • Author(s): Chiemi Nishida, Kaori Kusubata, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig, Koichi Hattori
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場、名古屋市
  • Year and Date: 2011-10-15
• [Presentation] Aplasmin inhibitor prevents lethal acute graft-versus-host disease in mice (2011)
  • Author(s): Aki Sato、Yoshihiko Tashiro, Chiemi Nishida, Ismael Gritli Kaori Kusubata Heissig Beate Koichi Hattori
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場、名古屋市
  • Year and Date: 2011-10-15
• [Presentation] Fibrinolytic factors regulate tumor progression and growth by altering the interaction between cells of the tumor microenvironment (2011)
  • Author(s): Beate Heissig, Hattori K
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] リンパ腫に対する骨髄由来細胞動員及びマトリックスメタロプロテイナーゼ活性制御を伴うプラスミン阻害剤の有効性 (2011)
  • Author(s): 服部浩一
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場、名古屋市
  • Year and Date: 2011-10-03
• [Presentation] The proteolytic bone marrow niche : The impact of membrane type-1 matrix metalloproteinase and plasminogen dificiency on hematopoiesis (2011)
  • Author(s): Beate Heissig, Hattori K
  • Organizer: 2011年度日独がんワークショップ
  • Place of Presentation: グランドプリンスホテル広島(広島県)(招待講演)
  • Year and Date: 2011-09-18
• [Presentation] 血液線維素溶解系の亢進における骨髄内間葉系幹細胞の増殖 (2011)
  • Author(s): 楠畑かおり, 服部浩一
  • Organizer: 平成23年度がん若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科(長野県)
  • Year and Date: 2011-09-03
• [Presentation] The role of G-CSF combination in conditioning regimen for CBT patients with AML Bone Marrow Transplant (2011)
  • Author(s): Takahashi S, et al
  • Organizer: 第37回ヨーロッパ骨髄移植学会(EBMT)
  • Place of Presentation: フランス、パリ市
  • Year and Date: 2011-04-04
• [Presentation] Matched HLA Haplotype Contributes to Reduce Sever Acute GVHD with Conserving GVL Effect in HLA-Mismatched Cord Blood Transplantation (2011)
  • Author(s): Takahashi S, Ooi J, Kato S, Kawakita T, Tojo A, Ebihara Y, Mochizuki S, Yamamoto S, Tsuji K, Yamaguchi T, Morishima S, Morishima Y, Asano S
  • Organizer: Blood 118(21): 1771. Abstr.# 4140, 53回アメリカ血液学会
  • Place of Presentation: サンディエゴSan Diego Convention Center
• [Presentation] MT1-MMP Regulates Hematopoiesis Through HIF-Mediated Chemo-/Cytokine Release From the Bone Marrow Niche (2011)
  • Author(s): Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig and Koichi Hattori
  • Organizer: 53回アメリカ血液学会
  • Place of Presentation: サンディエゴSan Diego Convention Center
• [Presentation] A plasmin Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice (2011)
  • Author(s): Aki Sato, Yoshihiko Tashiro, Chiemi Nishida, Ismael Gritli Kaori Kusubata, Satoshi Takahashi, Hiromitsu Nakauchi, Beate Heissig, Koichi Hattori
  • Organizer: 53回アメリカ血液学会
  • Place of Presentation: サンディエゴSan Diego Convention Center
• [Presentation] Japan Cord Blood Bank Network. The role of G-CSF combination in conditioning regimen for CBT patients with AML Bone Marrow Transplant (2011)
  • Author(s): Takahashi S, Ooi J, Kato S, Kawakita T, Nakauchi Y, Monna M, Nagamura T, Kato K, Yamaguchi T., Asano S
  • Organizer: 第37回欧州造血細胞移植学会
  • Place of Presentation: パリ
• [Presentation] Contribution of the fibrinolytic system to hematopoiesis and angiogenesis during tissue regeneration (2010)
  • Author(s): 服部浩一
  • Organizer: 第33回日本血栓止血学会学術集会学術推進委員会(SPC)シンポジウム招待講演
  • Place of Presentation: 城山観光ホテル、鹿児島
  • Year and Date: 2010-04-22
• [Presentation] 生体内組織再生における骨髄由来間葉系幹細胞の動態解析 (2010)
  • Author(s): 服部浩一
  • Organizer: 第9回日本再生医療学会総会シンポジウム指名講演
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] The impact of cytomegalovirus reactivation after cord blood transplantation in Adults (2010)
  • Author(s): Takahashi S, T. Yamaguchi, J. Ooi, N. Tsukada, S. Kato, T. Kawakita, T. Yagyu, M. Monna-ooiwa, A. Tojo, S. Asano
  • Organizer: 第36回欧州造血細胞移植学会
  • Place of Presentation: ウィーン
• [Presentation] MT1-MMP is a critical modulator of normal hematopoiesis (2010)
  • Author(s): Chiemi Nishida, Heissig, Motoharu Seiki, Hiromitsu Nakauchi, Koichi Hattori
  • Organizer: 第72回日本血液学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Single cord blood transplantation followed by myeloablative regimen for adults? Recent progress in Japan (2010)
  • Author(s): Takahashi S
  • Organizer: World Cord Blood Congress
  • Place of Presentation: Marseille, France
• [Presentation] Myeloablative Cord Blood Transplantation-Recent Progress and Experience from The Institute of Medical Science, The University of Tokyo (2010)
  • Author(s): Takahashi S
  • Organizer: The Asian Workshop for Hematopoietic Stem Cell Transplantation 2010
  • Place of Presentation: Beppu
• [Presentation] Asia Cord blood transplantation : Experience in IMSUT (2009)
  • Author(s): Takahashi S
  • Organizer: XXth Regional Congress of the ISBT
  • Place of Presentation: Nagoya
  • Year and Date: 2009-11-16
• [Presentation] Cord blood transplantation in adults with ablative conditioning regimen in Japan (2009)
  • Author(s): Takahashi S
  • Organizer: The First Meeting of Japan-Korea Cord Blood Symposium
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2009-11-14
• [Presentation] Cord blood transplantation(CBT) in adults with ablative conditioning regimen : update of IMSUT experience (2009)
  • Author(s): Takahashi S
  • Organizer: The international symposium for 10th anniversary of Japan cord blood bank network
  • Place of Presentation: Tokyo
  • Year and Date: 2009-08-30
• [Presentation] Impact of HLA Haplotype matching for mismatched cord blood transplantation (2009)
  • Author(s): Takahashi S, J. Ooi, N. Tsukada, S. Kato, A. Sato, T. Kawakita, Y. Nagata, M. Monna-ooiwa, A. Tojo, T. Yamaguchi, S. Morishima, Y. Morishima, S. Asano
  • Organizer: Abstr.# 1206, 51回アメリカ血液学会
  • Place of Presentation: ニューオーリンズ
• [Presentation] 臍帯血移植に関する臨床的留意点 (2009)
  • Author(s): 高橋聡
  • Organizer: Morning Conference第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] Cord Blood Stem Cell Transplantation and Hematology Classes Progress【Item No.: 2009-03-04-063(the country)】 (2009)
  • Author(s): Takahashi S
  • Organizer: The Cord Blood Hematopoietic Stem Cell Transplantation-level Seminars and Medical Education Project
  • Place of Presentation: Hefei, China
• [Book] 血液がん.がん患者のこころの寄り添うために-サイコオンコロジーの基礎と実線- (2010)
  • Author(s): 高橋聡、加藤せい子
  • Publisher: 真興交易医書出版部
• [Book] 移植の適応2010-東大医科研における考え方- (2010)
  • Author(s): 高橋聡
  • Publisher: 先端医療研究支援機構
• [Book] 多植の適応2010-東大医科研における考え方- (2010)
  • Author(s): 高橋聡
  • Publisher: 先端医療研究支援機構
• [Book] 血液がん.がん患者のこころの寄り添うために-サイコオンコロジ・の基礎と実線- (2010)
  • Author(s): 高橋聡, 加藤せい子
  • Publisher: 真興交易医書出版部
• [Remarks]
  • URL: http://stemcell-u-tokyo.org/sc-re/
• [Remarks]
  • URL: http://ganshien.umin.jp/public/research/main/heissig/index.html
• [Patent(Industrial Property Rights)] 炎症性疾患治療剤 (2011)
  • Inventor(s): 服部浩一、津田裕子、服部・ハイジッヒ・ベアテ
  • Industrial Property Number: 2011-211450
  • Filing Date: 2011-09-27
  • Overseas