FcRγchain-dependent signaling in basophils

• Project/Area Number: 21591238
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Shinshu University
• Principal Investigator: HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サイトカイン / 好塩基球 / シグナル伝達 / Th2 / 抗体 / FcRγ / IRF

Research Abstract

Basophils have recently been recognized as a mediator of type 2 immune responses producing interleukin-4(IL-4) in response to various stimuli including T cell-derived IL-3. However, little information is available for the signaling pathway of IL-3-induced IL-4 production in basophils. In this study, we showed that FcRγ-dependent signaling in basophils was modulated by a variety of factors such as their activation status and negative regulators.

Research Products

• [Journal Article] IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice (2011)
  • Author(s): o sh izawa K, Nakajima S, Notake S, Miyagawa S, Hida S, Taki, S
  • Journal Title: J. Immunol Volume: 187 Issue: 10 Pages: 5162-5169
  • DOI: 10.4049/jimmunol.1101561
  • NAID: 120007108237
  • Peer Reviewed
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia. (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
  • Journal Title: Cardiovasc Res Volume: 90 Issue: 2 Pages: 362-372
  • DOI: 10.1093/cvr/cvq397
  • Peer Reviewed
• [Journal Article] IFN-γdeficiency worsen Pneumocystis pneumonia with Th17 development in nude mice (2009)
  • Author(s): Hu, T, Takamoto, M, Hida, S, Tagawa, YI, and Sugane, K
  • Journal Title: Immunol. Lett. Volume: 127(1) Pages: 55-59
  • URL: http://dx.doi.org/10.1016/j.imlet.2009.08.013
  • Peer Reviewed
• [Journal Article] IFN-γ deficiency worsen Pneumocystis pneumonia with Th17 development in unde mice (2009)
  • Author(s): Hu Tao, Takamoto Masaya, Hida Shigeaki, et al.
  • Journal Title: Immunology Letter 127 Pages: 55-59
  • Peer Reviewed
• [Journal Article] 好塩基球のIL-3受容体に会合するFcRγ鎖の機能 (2009)
  • Author(s): 肥田重明、瀧伸介
  • Journal Title: 感染 炎症 免疫 39 Pages: 75-79
• [Journal Article] アレルギー疾患の免疫機構 (2009)
  • Author(s): 瀧伸介、肥田重明
  • Journal Title: 実験医学:増刊号 27 Pages: 75-82
• [Presentation] IL-3-induced IL-13 production by Basophils but not mast cells was sensitive to PIR-B mediated inhibitory signals (2011)
  • Author(s): ODA A, SAKAMOTO Y, SANJO H, NOTAKE T, TAKAI T, HIDA S, TAKI S
  • Organizer: 第40回日本免疫学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] IL-3-induced IL-13 production by Basophils but not mast cells was sensitive to PIR-B mediated inhibitory signals (2011)
  • Author(s): ODA A, SAKAMOTO Y, SANJO H, NOTAKE T, TAKAI T, HIDA S, TAKI S
  • Organizer: 第40回日本免疫学会学術総会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] IL-15-independent generation of memory-like" innate "CD8^+ T cells in IRF-2 deficient mice (2011)
  • Author(s): NOTAKE T, ODA A, SANJO H, HIDA S, TAKI S
  • Organizer: 第40回日本免疫学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] IL-15-independent generation of memory-like "innate" CD8^+T cells in IRF-2 deficient mice (2011)
  • Author(s): NOTAKE T, ODA A, SANJO H, HIDA S, TAKI S
  • Organizer: 第40回日本免疫学会学術総会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] The role of apoptosis-associated speck like protein containing a CARD(ASC) in antitumor effect of macrophage (2011)
  • Author(s): OKADA N, KITAZAWA M, FUJII C, HIDA S, TANIGUCHI S
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] The role of apoptosis-associated speck like protein containing a CARD (ASC) in antitumor effect of macrophage (2011)
  • Author(s): OKADA N, KITAZAWA M, FUJII C, HIDA S, TANIGUCHI S
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] A novel tumor-suppressor functions of ASC in fibrosarcoma (2011)
  • Author(s): KITAZAWA M, HIDA S, OKADA N, MATSUMURA T, FUJII C, TAKEOKA M, MIYAGAWA S, TANIGUCHI S
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] A novel tumor-suppressor functions of ASC in fibrosarcoma (2011)
  • Author(s): KITAZAWA M, HIDA S, OKADA N, MATSUMURA T, FUJII C, TAKEOKA M, MIYAGAWA S, TANIGUCHI S
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] Generation of CD1d-independent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially (2010)
  • Author(s): NOTAKE T, HORISAWA S, ARAKURA F, HIDA S, TAKI S
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 兵庫
  • Year and Date: 2010-08-25
• [Presentation] Paired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils (2010)
  • Author(s): ODA A, SAKAMOTO Y, TAKAI T, HIDA S, TAKI S
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 兵庫
  • Year and Date: 2010-08-24
• [Presentation] Basophils sense various external signals with their FcRγ-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses (2010)
  • Author(s): HIDA S, ODA A, KOSHI I, TAKI S
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 兵庫
  • Year and Date: 2010-08-23
• [Presentation] The role of IFN-γand IL-17 on Pneumocysite pneumonia in nude mice. (2010)
  • Author(s): TAKAMOTO M, HU T, HIDA S, TAGAYA Y, SUGANE K
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 兵庫
  • Year and Date: 2010-08-23
• [Presentation] Basophils sense various external signals with their FcRγ｀-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses (2010)
  • Author(s): Shigeaki Hida, Akihisa 0da, Ippei Koshi, Shinsuke Taki
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 日本 神戸市ポートピアホテル、国際展示場
  • Year and Date: 2010-08-23
• [Presentation] Generation of CD1d-independent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially (2009)
  • Author(s): NOTAKE T, HIDA S, TAKI S
  • Organizer: 第39回日本免疫学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Basophils" sense" protease allergens with their FcRγ-associated cell surface molecule(s) to produce IL-4 (2009)
  • Author(s): HIDA S, ODA A, YAMASAKI S, SAITO T, TAKI S
  • Organizer: 第39回日本免疫学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Pired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent mannar in murine basophils (2009)
  • Author(s): SAKAMOTO Y, ODA A, TAKAI Y, HIDA S, TAKI S
  • Organizer: 第39回日本免疫学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Basophils "sense" protease allergens with their FcRγ-associated cell surface molecule (s) to produce IL-4 (2009)
  • Author(s): 肥田重明
  • Organizer: 第39回 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Book] 「Th2分化と好塩基球.」実験医学 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Publisher: 羊土社
• [Book] 「好塩基球からのIL-4産生誘導機序.」炎症と免疫 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Publisher: 先端医学社
• [Book] 実験医学 増刊 「サイトカインによる免疫制御と疾患」 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Publisher: 羊土社
• [Book] 「好塩基球のIL-3受容体に会合するFcRγ鎖の機能.」感染炎症免疫 (2009)
  • Author(s): 肥田重明、瀧伸介
  • Publisher: 医薬の門社
• [Book] 「好塩基球のIL-4産生における細胞内シグナル伝達機構.」実験医学 (2009)
  • Author(s): 瀧伸介、肥田重明
  • Publisher: 羊土社
• [Book] 「IL-3レセプターシグナルによる好塩基球のサイトカイン産生制御の解明.」医学のあゆみ (2009)
  • Author(s): 肥田重明、瀧伸介
  • Publisher: 医歯薬出版
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-bunshishuyo/index.html
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.htm