FcRγchain-dependent signaling in basophils
| Project/Area Number |
21591238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Shinshu University |
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Principal Investigator |
HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | サイトカイン / 好塩基球 / シグナル伝達 / Th2 / 抗体 / FcRγ / IRF |
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| Research Abstract |
Basophils have recently been recognized as a mediator of type 2 immune responses producing interleukin-4(IL-4) in response to various stimuli including T cell-derived IL-3. However, little information is available for the signaling pathway of IL-3-induced IL-4 production in basophils. In this study, we showed that FcRγ-dependent signaling in basophils was modulated by a variety of factors such as their activation status and negative regulators.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia.2011
Author(s)
Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
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Journal Title
Cardiovasc Res
Volume: 90
Issue: 2
Pages: 362-372
DOI
Related Report
Peer Reviewed
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