| Project/Area Number |
21591242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ORITANI Kennji 大阪大学, 大学院・医学系・研究科, 准教授 (70324762)
KASHIWAGI Hirokazu 大阪大学, 大学院・医学系・研究科, 助教 (10432535)
SHIRAGA Masamichi 大阪大学, 大学院・医学系・研究科, 助教 (40397683)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | αIIbβ3 / P2Y12 / 巨核系細胞株 / GPVI / トロンボキサンA2 / αIIbss3 / inside-out signaling / トロンボキサンA2受容体 / ADP / 遺伝子異常 / αアクチニン / CMK細胞 / 自己抗体 / P2Y_<12> / α_<IIb>β_3 |
|---|
| Research Abstract |
Platelet function is regulated in the balance of positive and negative regulators. In this study, we have characterized ADP receptor P2Y12, collagen receptor GPVI, and thromboxane A2 receptor as positive regulators in patients with abnormality of these receptors. Of interest is that P2Y12-mediated signaling plays a critical role in the sustained. IIb. 3 activation. Inversely, we demonstrayed that.-actinin plays as a negative regulator and negatively regulate. IIb. 3 activation.
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