Analysis of positive or negative regulatory mechanism for thrombus formation
| Project/Area Number |
21591242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ORITANI Kennji 大阪大学, 大学院・医学系・研究科, 准教授 (70324762)
KASHIWAGI Hirokazu 大阪大学, 大学院・医学系・研究科, 助教 (10432535)
SHIRAGA Masamichi 大阪大学, 大学院・医学系・研究科, 助教 (40397683)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | αIIbβ3 / P2Y12 / 巨核系細胞株 / GPVI / トロンボキサンA2 / αIIbss3 / inside-out signaling / トロンボキサンA2受容体 / ADP / 遺伝子異常 / αアクチニン / CMK細胞 / 自己抗体 / P2Y_<12> / α_<IIb>β_3 |
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| Research Abstract |
Platelet function is regulated in the balance of positive and negative regulators. In this study, we have characterized ADP receptor P2Y12, collagen receptor GPVI, and thromboxane A2 receptor as positive regulators in patients with abnormality of these receptors. Of interest is that P2Y12-mediated signaling plays a critical role in the sustained. IIb. 3 activation. Inversely, we demonstrayed that.-actinin plays as a negative regulator and negatively regulate. IIb. 3 activation.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the {alpha}IIb{beta}3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia2011
Author(s)
Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H
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Journal Title
Blood
Volume: 117
Issue: 20
Pages: 5479-5484
DOI
Related Report
Peer Reviewed
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[Presentation] Agonist stimulation, talin-1, and kindlin-3 are crucial forαIIbβ3 activation in a human megakaryoblastic cell line, CMK2011
Author(s)
Nakazawa T, Tadokoro S, Kiyomizu K, Kashiwagi H, Honda S, Tomiyama Y, Kanakura Y.
Organizer
The 53rd Annual Meeting of the American Society of Hematology
Place of Presentation
San Diego, USA
Year and Date
2011-12-11
Related Report
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[Presentation] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK2011
Author(s)
Nakazawa T, Tadokoro S, Kiyomizu K, Kashiwagi H, Honda S, Tomiyama Y, Kanakura Y
Organizer
The 53rd Annual Meeting of the American Society of Hematology
Place of Presentation
San Diego, USA
Year and Date
2011-12-11
Related Report
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[Presentation] 治療抵抗性慢性特発性血小板減少性紫斑病(ITP)患者に対するエルトロンボパグの臨床試験成績2010
Author(s)
冨山佳昭, 宮川義隆, 岡本真一郎, 勝谷慎也, 木村昭郎, 大越靖, 二宮治彦, 小杉浩史, 野村昌作, 尾崎勝俊, 池田康夫, 小尾伸之, 桂幸一, 金倉譲
Organizer
第33回日本血栓止血学会学術集会
Place of Presentation
鹿児島、城山観光ホテル
Year and Date
2010-04-24
Related Report
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[Presentation] Six month treatment of low dose eltrombopag is rfficacious in Japanese patients with refractory chronic immune thrombocytopenic purpura(ITP)2009
Author(s)
Tomiyama Y, Miyakawa Y, Okamoto S, Katsutani S, Kimura A, Okoshi Y, Ninomiya H, Kosugi H, Nomura S, Ozaki K, Ikeda Y, Koh N, Katsura K, Kanakura Y
Organizer
The 51st Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans, USA
Year and Date
2009-12-05
Related Report
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