VITAMIN D RECEPTOR IS A PIVOT OF THE BRAIN-BONE-BLOOD TRIANGLE FOR HEMATOPOIETIC STEM CELL NICHE
Project/Area Number |
21591243
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Yoshio 神戸大学, 医学部附属病院, 講師 (80397885)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | ビタミンD受容体 / 交感神経 / 造血幹細胞ニッチ / G-CSF / 骨芽細胞 / 造血幹細胞 / 造血ニッチ / 幹細胞動 / VDRノックアウトマウス / 幹細胞動員 |
Research Abstract |
Bloods are born in the bone. Here, we present the severe impairment of granulocyte-colony stimulating factor(G-CSF)-induced hematopoietic stem cell(HSC) mobilization in vitamin D receptor(VDR) deficient mice. VDR is essential for durableβ2-adrenergic receptor signaling in stem cell niche. Our study demonstrates not only a novel function of VDR as a critical modulator of HSC trafficking, but also the presence of a sympathetic nervous system-mediated bone remodeling mechanism through VDR. VDR plays a pivotal role in the regulation of hematopoietic stem cell niche.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche2010
Author(s)
Kawamori, Y., Katavama, Y., Asada, N., Minagawa, K., Sato, M., Okamura, A., Shimoyama, M., Nakagawa, K., Okano, T., Tanimoto, M., Kato, S., Matsui, T.
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Journal Title
Blood
Volume: 116
Pages: 5528-5535
Related Report
Peer Reviewed
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[Journal Article] Progressive osteosclerosis and visceral calcification after cord blood transplantation2010
Author(s)
Asada, N., Ishii, S. Wakahashi, K., Kawano, H., Kawamori, Y., Nishikawa, S., Minagawa, K., Okamura, A., Shimoyama, M., Katayama, Y., Hayashi, Y., Itoh, T., Tanimoto, M. and Matsui, T.
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Journal Title
Int. J. Hematol
Volume: 91
Pages: 542-5
NAID
Related Report
Peer Reviewed
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