| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We have shown that splenocytes from IL-21R-deficient mice ameliorates GVHD as compared to that from wild-type mice and that a decoy receptor for IL-21 attenuates GVHD. This time, we aimed to investigate the mechanisms for the attenuated GVHD by blocking IL-21.We found that the production of cytokines was impaired in effector T cells and an increase of Treg cells in spleen. A depletion of Treg cells by anti-CD25 antibody did not change the attenuation of GVHD by blocking IL-21, suggesting that the cause of attenuation of GVHD could be the loss of functional effector cells rather than the increase of Treg cells.
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