Regulation of plasminogen activator inhibitor-1 promotes the immune response to factor VIII in murine hemophilia A.

• Project/Area Number: 21591249
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Jichi Medical University
• Principal Investigator: MADOIWA Seiji 自治医科大学, 医学部, 講師 (70296119)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Eiji 自治医科大学, 医学部, 教授 (00245044) ; OHOMORI Tsukasa 自治医科大学, 医学部, 講師 (70382843)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血友病A / インヒビター / 免疫寛容 / 第VIII因子欠損マウス / PAI-1欠損マウス

Research Abstract

The development of inhibitory antibodies against factor VIII(FVIII) is the enormous impact on hemophilia A patients, who are treated with FVIII products. Plasminogen activator-plasmin system is associated with not only thrombolysis but also various reactions including inflammation. However, little is known about how fibrinolytic components coordinate immune response. Here we show that plasminogen activator inhibitor-1(PAI-1), a regulator of fibrinolytic system, is a key player in controlling immune response in a mouse model of hemophilia A. Genetic deletion of PAI-1 prevented FVIII deficient mice from development of inhibitor formation after repeated loading of FVIII. PAI-1 depletion was associated with decreased major histocompatibility complex class II expression by bone marrow F4/80 positive cells and reduced T cell proliferation. Transplantation of mouse bone marrow cells transduced with a short hairpin RNA sequence targeting PAI-1 as well as administration of synthetic PAI-1 inhibitor caused a significant reduction of anti-FVIII antibody titer in FVIII deficient mice. These results suggest that PAI-1 regulation before FVIII exposure may represent a novel therapeutic option for preventing the development of FVIII inhibitors in hemophilia A patients.

Research Products

• [Journal Article] Il2rg Gene-Targeted Severe Combined Immunodeficiency(SCID) Pigs (2012)
  • Author(s): Suzuki, S., Iwamoto, M., Saito, Y., Fuchimoto, D., Sembon, S., Suzuki, M., Mikawa, S., Hashimoto, M., Aoki, Y., Najima, Y., Takagi, S., Suzuki, N., Suzuki, E., Kubo, M., Mimuro, J., Kashiwakura, Y., Madoiwa, S., Sakata, Y., Perry, A. C. F., Ishikawa, F.
  • Journal Title: Cell Stem Cell Volume: (in press)
• [Journal Article] Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice (2012)
  • Author(s): Madoiwa, S., Kobayashi, E., Kashiwakura, Y., Sakata, A., Yasumoto, A., Ohmori, T., Mimuro, J., and Sakata, Y
  • Journal Title: Haemophilia Volume: 18
• [Journal Article] Lack of association between serum paraoxonase-1 activity and residual platelet aggregation during dual anti-platelet therapy (2012)
  • Author(s): Ohmori, T., Yano, Y., Sakata, A., Ikemoto, T., Shimpo, M., Madoiwa, S., Katsuki, T., Mimuro, J., Shimada, K., Kario, K., et al
  • Journal Title: Thromb Res Volume: 129
• [Journal Article] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms (2012)
  • Author(s): Norimatsu, Y., Ohmori, T., Kimura, A., Madoiwa, S., Mimuro, J., Seichi, A., Yatomi, Y., Hoshino, Y., and Sakata, Y
  • Journal Title: Am J Pathol Volume: 180 Pages: 1625-1635
• [Journal Article] Il2rg Gene-Targeted Severe Combined Immunodeficiency (SCID) Pigs (2012)
  • Author(s): Suzuki, S., et al.
  • Journal Title: Cell Stem Cell Volume: (in press)
  • Peer Reviewed
• [Journal Article] Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice (2012)
  • Author(s): Madoiwa, S., et al.
  • Journal Title: Haemophilia Volume: 18 Issue: 3
  • DOI: 10.1111/j.1365-2516.2011.02686.x
  • Peer Reviewed
• [Journal Article] Lack of association between serum paraoxonase-1 activity and residual platelet aggregation during dual anti-platelet therapy (2012)
  • Author(s): Ohmori, T., et al.
  • Journal Title: Thromb Res Volume: 129 Issue: 4 Pages: e36-e40
  • DOI: 10.1016/j.thromres.2011.10.033
  • Peer Reviewed
• [Journal Article] Predictive blood coagulation markers for early diagnosis of venous thromboembolism after total knee joint replacement (2011)
  • Author(s): Watanabe, H., Madoiwa, S., Sekiya, H., Nagahama, Y., Matsuura, S., Kariya, Y., Ohmori, T., Mimuro, J., Hoshino, Y., Hayasaka, S., et al
  • Journal Title: Thromb Res Volume: 128
• [Journal Article] Local regulation of neutrophil elastase activity by endogenous alpha1-antitrypsin in lipopolysaccharide-primed hematological cells (2011)
  • Author(s): Dokai, M., Madoiwa, S., Yasumoto, A., Kashiwakura, Y., Ishiwata, A., Sakata, A., Makino, N., Ohmori, T., Mimuro, J., and Sakata, Y
  • Journal Title: Thromb Res Volume: 128 Pages: 283-292
• [Journal Article] Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation (2011)
  • Author(s): Madoiwa, S., Tanaka, H., Nagahama, Y., Dokai, M., Kashiwakura, Y., Ishiwata, A., Sakata, A., Yasumoto, A., Ohmori, T., Mimuro, J., et al
  • Journal Title: Thromb Res Volume: 127 Pages: 349-355
• [Journal Article] Predictive blood coagulation markers for early diagnosis of venous thromboembolism after total knee joint replacement (2011)
  • Author(s): Watanabe, H., et al.
  • Journal Title: Thromb Res Volume: 128
  • Peer Reviewed
• [Journal Article] Cross-linked fibrin degradation products by leukocyte elastase (e-XDP) (2011)
  • Author(s): Madoiwa, S., et al.
  • Journal Title: Rinsho Byori Volume: 147 Suppl Pages: 65-70
• [Journal Article] Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation. (2011)
  • Author(s): Madoiwa, S.
  • Journal Title: Thromb Res Volume: 127 Pages: 349-355
  • Peer Reviewed
• [Journal Article] Vinculin activates inside-out signaling of integrin alphaIIbbeta3 in Chinese hamster ovary cells (2010)
  • Author(s): Ohmori, T., Kashiwakura, Y., Ishiwata, A., Madoiwa, S., Mimuro, J., Honda, S., Miyata, T., and Sakata, Y
  • Journal Title: Biochem Biophys Res Commun Volume: 400 Pages: 323-328
• [Journal Article] Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC (2010)
  • Author(s): Wada, H., Hatada, T., Okamoto, K., Uchiyama, T., Kawasugi, K., Mayumi, T., Gando, S., Kushimoto, S., Seki, Y., Madoiwa, S., et al
  • Journal Title: Am J Hematol Volume: 85 Pages: 691-694
• [Journal Article] Frequency and hemostatic abnormalities in pre-DIC patients (2010)
  • Author(s): Okamoto, K., Wada, H., Hatada, T., Uchiyama, T., Kawasugi, K., Mayumi, T., Gando, S., Kushimoto, S., Seki, Y., Madoiwa, S., et al
  • Journal Title: Thromb Res Volume: 126 Pages: 74-78
• [Journal Article] Vinculin is indispensable for repopulation by hematopoietic stem cells (2010)
  • Author(s): Ohmori, T., Kashiwakura, Y., Ishiwata, A., Madoiwa, S., Mimuro, J., Furukawa, Y., and Sakata, Y
  • Journal Title: Vinculin is indispensable for repopulation by hematopoietic stem cells Volume: 285 Pages: 31763-31773
• [Journal Article] Mutant macaque factor IX T262A : a tool for hemophilia B gene therapy studies in macaques (2010)
  • Author(s): Ishiwata, A., Mimuro, J., Mizukami, H., Kashiwakura, Y., Yasumoto, A., Sakata, A., Ohmori, T., Madoiwa, S., Ono, F., Shima, M., et al
  • Journal Title: Thromb Res Volume: 125 Pages: 533-537
• [Journal Article] Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation (2010)
  • Author(s): Mimuro, J., Mizuta, K., Kawano, Y., Hishikawa, S., Hamano, A., Kashiwakura, Y., Ishiwata, A., Ohmori, T., Madoiwa, S., Kawarasaki, H., et al
  • Journal Title: Pediatr Transplant Volume: 14 Pages: 369-376
• [Journal Article] Expert consensus for the treatment of disseminated intravascular coagulation in Japan (2010)
  • Author(s): Wada, H., Asakura, H., Okamoto, K., Iba, T., Uchiyama, T., Kawasugi, K., Koga, S., Mayumi, T., Koike, K., Gando, S., Madoiwa, S., et al
  • Journal Title: Thromb Res Volume: 125 Pages: 6-11
• [Journal Article] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice (2010)
  • Author(s): Ishiwata, A., Mimuro, J., Mizukami, H., Kashiwakura, Y., Takano, K., Ohmori, T., Madoiwa, S., Ozawa, K., and Sakata, Y.
  • Journal Title: J Gene Med Volume: 11 Pages: 1020-1029
• [Journal Article] Vinculin activates inside-out signaling of integrin alphaIIbbeta3 in Chinese hamster ovary cells. (2010)
  • Author(s): Ohmori, T.
  • Journal Title: Biochem Biophys Res Commun Volume: 400 Pages: 323-328
  • Peer Reviewed
• [Journal Article] Dynamics of blood coagulation and fibrinolysis and laboratory findings in disseminated intravascular coagulation. (2010)
  • Author(s): Madoiwa, S.
  • Journal Title: Rinsho Ketsueki Volume: 51 Pages: 20-28
  • NAID: 10026331957
• [Journal Article] Mutant macaque factor IX T262A : a tool for hemophilia B gene therapy studies in macaques. (2010)
  • Author(s): Ishiwata, A.
  • Journal Title: Thromb Res Volume: 125 Pages: 533-537
  • Peer Reviewed
• [Journal Article] Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function. (2010)
  • Author(s): Ohmori, T.
  • Journal Title: J Biol Chem Volume: 285 Pages: 31763-31773
  • Peer Reviewed
• [Journal Article] Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation. (2010)
  • Author(s): Mimuro, J.
  • Journal Title: Pediatr Transplant Volume: 14 Pages: 369-376
  • Peer Reviewed
• [Journal Article] Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC. (2010)
  • Author(s): Wada, H.
  • Journal Title: Am J Hematol Volume: 85 Pages: 691-694
  • Peer Reviewed
• [Journal Article] Frequency and hemostatic abnormalities in pre-DIC patients. (2010)
  • Author(s): Okamoto, K.
  • Journal Title: Thromb Res Volume: 126 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Expert consensus for the treatment of disseminated intravascular coagulation in Japan. (2010)
  • Author(s): Wada, H.
  • Journal Title: Thromb Res Volume: 125 Pages: 6-11
  • Peer Reviewed
• [Journal Article] 特集:血友病のインヒビターを考察する「総説」インヒビターの発生と免疫寛容 (2010)
  • Author(s): 窓岩清治
  • Journal Title: 日本血栓止血学会誌 Volume: 21 Pages: 496-505
• [Journal Article] 感染症DICを考慮した現厚生労働省DIC診断基準の検討 (2010)
  • Author(s): 窓岩清治
  • Journal Title: 日本血栓止血学会誌 Volume: 21 Pages: 595-599
  • NAID: 10027675302
• [Journal Article] Mutant Macaque Factor IX T262A : A Tool for Hemophilia B Gene Therapy Studies in Macaques (2010)
  • Author(s): Ishiwata, A., et al.
  • Journal Title: Thromb Res (in press)
  • Peer Reviewed
• [Journal Article] Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation (2010)
  • Author(s): Mimuro, J., et al.
  • Journal Title: Pediatr Transplant (in press)
  • Peer Reviewed
• [Journal Article] Expert consensus for the treatment of disseminated intravascular coagulation in Japan (2010)
  • Author(s): Wada H., et al.
  • Journal Title: Thromb Res 125 Pages: 6-11
  • Peer Reviewed
• [Journal Article] Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A (2009)
  • Author(s): Madoiwa, S., Yamauchi, T., Kobayashi, E., Hakamata, Y., Dokai, M., Makino, N., Kashiwakura, Y., Ishiwata, A., Ohmori, T., Mimuro, J., et al
  • Journal Title: J Thromb Haemost Volume: 7 Pages: 811-824
• [Journal Article] Association of Asn221Ser mutation in tissue factor pathway inhibitor-beta with plasma total tissue factor pathway inhibitor level (2009)
  • Author(s): Ishikawa, J., Okada, H., Kato, H., Takeshita, S., Honda, S., Kawasaki, T., Suehisa, E., Tsuji, H., Madoiwa, S., Sakata, Y., et al
  • Journal Title: Blood Coagul Fibrinolysis Volume: 20 Pages: 22-26
• [Journal Article] Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis (2009)
  • Author(s): Miyata, T., Sato, Y., Ishikawa, J., Okada, H., Takeshita, S., Sakata, T., Kokame, K., Kimura, R., Honda, S., Kawasaki, T., Madoiwa, S., et al
  • Journal Title: Thromb Res Volume: 124 Pages: 14-18
• [Journal Article] Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII infection in murine hemophilia A (2009)
  • Author(s): Madoiwa, S., et al.
  • Journal Title: J Thromb Haemost 7 Pages: 811-824
  • Peer Reviewed
• [Journal Article] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice (2009)
  • Author(s): Ishiwata, A., et al.
  • Journal Title: J Gene Med 11 Pages: 1020-1029
  • Peer Reviewed
• [Journal Article] Association of Asn221Ser mutation in tissue factor pathway inhibitor-[beta] with plasma total tissue factor pathway inhibitor level. Blood Coagulation & Fibrinolysis (2009)
  • Author(s): Ishikawa, J., et al.
  • Journal Title: Blood Coagulation Fibrinolysis 20 Pages: 22-26
  • Peer Reviewed
• [Journal Article] Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis (2009)
  • Author(s): Miyata, T., et al.
  • Journal Title: Thromb Res 124 Pages: 14-18
  • Peer Reviewed
• [Presentation] 血友病の基礎と臨床-血友病インヒビター発生と免疫寛容 (2012)
  • Author(s): 窓岩清治
  • Organizer: 第115回日本小児科学会学術集会教育セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-20
• [Presentation] 血友病の基礎と臨床-血友病インヒビター発生と免疫寛容 (2012)
  • Author(s): 窓岩清治
  • Organizer: 第115回日本小児科学会学術集会教育セミナー
  • Place of Presentation: 福岡市(招待)
  • Year and Date: 2012-04-20
• [Presentation] 静脈血栓塞栓症に対する経口抗凝固療法の全国調査と自己モニタリングへの展開 (2011)
  • Author(s): 窓岩清治
  • Organizer: 第7回肺血栓塞栓症研究会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2011-11-01
• [Presentation] DICの病態-血栓溶解機構を把握する臨床的意義 (2011)
  • Author(s): 窓岩清治
  • Organizer: 第9回北陸血栓研究会特別講演
  • Place of Presentation: 金沢
  • Year and Date: 2011-10-29
• [Presentation] DICの病態-血栓溶解機構を把握する臨床的意義- (2011)
  • Author(s): 窓岩清治
  • Organizer: 第9回北陸血栓研究会特別講演
  • Place of Presentation: 金沢市(招待)
  • Year and Date: 2011-10-29
• [Presentation] Leukocyte elastase contributes to degradation of cross-linked fibrin in sepsis-induced DIC (2011)
  • Author(s): Madoiwa S., et al.
  • Organizer: The 73rd Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Nagoya
  • Year and Date: 2011-10-15
• [Presentation] 造血器悪性腫瘍とDIC-その病態と診断 (2011)
  • Author(s): 窓岩清治
  • Organizer: 第73回日本血液学会学術集会コーポレートセミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] 造血器悪性腫瘍とDIC-その病態と診断- (2011)
  • Author(s): 窓岩清治
  • Organizer: 第73回日本血液学会学術集会コーポレートセミナー
  • Place of Presentation: 名古屋市(招待)
  • Year and Date: 2011-10-14
• [Presentation] Leukocyte elastase contributes to degradation of cross-linked fibrin in sepsis-induced DIC (2011)
  • Author(s): Madoiwa S., et al
  • Organizer: The 73rd Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2011-10-11
• [Presentation] 血友病インヒビター発生に関する考察-動物モデルを用いた免疫寛容誘導法の研究- (2011)
  • Author(s): 窓岩清治
  • Organizer: 血友病PUPs研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-03
• [Presentation] 血友病インヒビター発生に関する考察-動物モデルを用いた免疫寛容誘導法の研究- (2011)
  • Author(s): 窓岩清治
  • Organizer: 血友病PUPs研究会
  • Place of Presentation: 東京(招待)
  • Year and Date: 2011-09-03
• [Presentation] Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation (2011)
  • Author(s): Madoiwa S., et al
  • Organizer: 23rd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2011-07-26
• [Presentation] Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation (2011)
  • Author(s): Madoiwa S., et al.
  • Organizer: 23rd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto
  • Year and Date: 2011-07-26
• [Presentation] Leukocyte elastase as an alternative pathway for fibrinolysis (2011)
  • Author(s): Madoiwa S., et al
  • Organizer: 57th Annual SSC Meeting
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2011-07-24
• [Presentation] Leukocyte elastase as an alternative pathway for fibrinolysis (2011)
  • Author(s): Madoiwa S., et al.
  • Organizer: 57th Annual SSC Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2011-07-24
• [Presentation] 敗血症における白血球エラスターゼの作用 (2011)
  • Author(s): 窓岩清治
  • Organizer: 第5回SIRS-DIC研究会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-07-01
• [Presentation] 敗血症における白血球エラスターゼの作用 (2011)
  • Author(s): 窓岩清治
  • Organizer: 第5回SIRS-DIC研究会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2011-07-01
• [Presentation] 線溶系から捉えたDICの病態-血栓溶解をどのように把握するか- (2011)
  • Author(s): 窓岩清治
  • Organizer: 第13回大阪DIC研究会特別講演
  • Place of Presentation: 大阪市
  • Year and Date: 2011-06-22
• [Presentation] 線溶系から捉えたDICの病態-血栓溶解をどのように把握するか- (2011)
  • Author(s): 窓岩清治
  • Organizer: 第13回大阪DIC研究会特別講演
  • Place of Presentation: 大阪市(招待)
  • Year and Date: 2011-06-22
• [Presentation] サイトカインストーム、特に敗血症DICにおける血栓溶解と白血球エラスターゼ (2011)
  • Author(s): 窓岩清治
  • Organizer: 第5回サイトカインストーム研究会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2011-02-04
• [Presentation] DICの病態と線溶系 (2011)
  • Author(s): 窓岩清治
  • Organizer: 2011日本DIC研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-29
• [Presentation] 血栓溶解の基礎と血栓溶解療法のガイドライン:血栓溶解薬-特徴と保険適応 (2010)
  • Author(s): 窓岩清治
  • Organizer: 第5回日本血栓止血学会学術標準化委員会血栓溶解部会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-10-30
• [Presentation] DICの病態・診断・治療～新規 & 分子マーカーの意義～敗血症DICにおける白血球エラスターゼによる血栓溶解の臨床的意義 (2010)
  • Author(s): 窓岩清治、, 他
  • Organizer: 第5回日本血栓止血学会学術標準化委員会DIC部会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-10-30
• [Presentation] 血栓溶解の基礎と血栓溶解療法のガイドライン-血栓溶解薬-特徴と保険適応 (2010)
  • Author(s): 窓岩清治
  • Organizer: 第5回日本血栓止血学会学術標準化委員会血栓溶解部会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-10-30
• [Presentation] DICの病態・診断・治療～新規&分子マーカーの意義～敗血症DICにおける白血球エラスターゼによる血栓溶解の臨床的意義 (2010)
  • Author(s): 窓岩清治
  • Organizer: 第5回日本血栓止血学会学術標準化委員会血栓溶解部会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-10-30
• [Presentation] DICの病態と診断-線溶系の観点から- (2010)
  • Author(s): 窓岩清治
  • Organizer: 第5回日本血栓止血学会学術標準化委員会ランチョンセミナー
  • Place of Presentation: 東京
  • Year and Date: 2010-10-30
• [Presentation] マイクロポート植え込み成体血友病Aマウスを用いた第VIII因子頻回刺激に対する免疫応答能の解析 (2010)
  • Author(s): 窓岩清治、, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] 敗血症における白血球エラスターゼの造血制御機構 (2010)
  • Author(s): 窓岩清治、, 他
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-04-23
• [Presentation] 担癌患者における血栓塞栓症 (2010)
  • Author(s): 窓岩清治
  • Organizer: 第8回日本臨床腫瘍学会学術集会教育講演
  • Place of Presentation: 東京
  • Year and Date: 2010-03-19
• [Presentation] 敗血症DICにおける血栓溶解機構のモニタリング (2010)
  • Author(s): 窓岩清治
  • Organizer: 第11回侵襲と生体反応研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-27
• [Presentation] 敗血症における白血球エラスターゼの造血制御機構 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第7回血液・血管フォ-ラム
  • Place of Presentation: 北九州
  • Year and Date: 2009-12-05
• [Presentation] 感染症DICを考慮した現厚生労働省診断基準の検討 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第4回日本血栓止血学会学術標準化委員会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-21
• [Presentation] 感染症DICを考慮した現厚生労働省診断基準の検討 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第4回日本血栓止血学会学術標準化委員会シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2009-11-21
• [Presentation] 線溶系からDICを捉える (2009)
  • Author(s): 窓岩清治
  • Organizer: 第20回九州血管血栓フォーラム
  • Place of Presentation: 熊本
  • Year and Date: 2009-11-07
• [Presentation] 線溶系からDICを捉える (2009)
  • Author(s): 窓岩清治
  • Organizer: 第20回九州血管血栓フォーラム
  • Place of Presentation: 熊本市
  • Year and Date: 2009-11-07
• [Presentation] 地域医療における血栓症・出血性疾患の診療 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第19回福井県地域医療学術集会
  • Place of Presentation: 福井県美浜町
  • Year and Date: 2009-10-24
• [Presentation] DICと線溶病態 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第9回群馬血栓止血研究会
  • Place of Presentation: 高崎市
  • Year and Date: 2009-10-16
• [Presentation] 悪性腫瘍と凝固線溶系 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第47回東北血栓止血研究会
  • Place of Presentation: 福島
  • Year and Date: 2009-09-12
• [Presentation] 悪性腫瘍と凝固線溶系 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第47回東北血栓止血研究会
  • Place of Presentation: 福島市
  • Year and Date: 2009-09-12
• [Presentation] Intrathymic administration of Factor VIII results in immune tolerance by induction of Factor VIII-specific regulatory T cells in murine hemophilia A (2009)
  • Author(s): Madoiwa S., et al
  • Organizer: 22nd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-16
• [Presentation] Intrathymic administration of Factor VIII results in immune tolerance by induction of Factor VIII-specific regulatory T cells in murine hemoph ilia A (2009)
  • Author(s): 窓岩清治
  • Organizer: XXII Congress of International Society on Thrombosis and Haemostasis
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-16
• [Presentation] DICにおける線溶系のモニタリング-その臨床的意義を考える (2009)
  • Author(s): 窓岩清治
  • Organizer: 第10回日本検査血液学会学術集会セミナー
  • Place of Presentation: 山梨
  • Year and Date: 2009-07-04
• [Presentation] DICにおける線溶系のモニタリング-その臨床的意義を考える- (2009)
  • Author(s): 窓岩清治
  • Organizer: 第10回日本検査血液学会学術集会
  • Place of Presentation: 甲府市
  • Year and Date: 2009-07-04
• [Presentation] Development of immune tolerance induction by intrathymic administration of Factor VIII in murine hemophilia A (2009)
  • Author(s): Madoiwa S., et al
  • Organizer: 2009 East Asia Hemophilia Forum
  • Place of Presentation: Kitakyushu
  • Year and Date: 2009-06-07
• [Presentation] Development of immune tolerance induction by intrathymic administration of Factor VIII in murine hemophilia A (2009)
  • Author(s): 窓岩清治
  • Organizer: 2009 East Asia Hemophilia Forum
  • Place of Presentation: Kitakyushu, Japan
  • Year and Date: 2009-06-07
• [Presentation] 敗血症における凝固線溶系異常 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第32回日本血栓止血学会学術集会
  • Place of Presentation: 北九州
  • Year and Date: 2009-06-05
• [Presentation] 敗血症における凝固線溶系異常 (2009)
  • Author(s): 窓岩清治
  • Organizer: 第32回日本血栓止血学会学術集会 日本血栓止血学会・日本救急医学会ジョイントシンポジウム
  • Place of Presentation: 北九州
  • Year and Date: 2009-06-05
• [Book] 血液専門医テキスト (2011)
  • Author(s): 窓岩清治, 他
  • Publisher: 南江堂
• [Book] 血液内科ゴールデンハンドブック2011年 (2011)
  • Author(s): 窓岩清治, 他
  • Publisher: 南江堂
• [Book] 血液内科ゴールデンハンドブック (2011)
  • Author(s): 窓岩清治, 他
  • Total Pages: 462
  • Publisher: 南江堂
• [Remarks]
  • URL: http://www.jichi.ac.jp/shiketsu/