Generation of platelets from human subcutaneous adipose tissues in a culture system
| Project/Area Number |
21591250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 輸血学 / 血小板 / 巨核球 / 脂肪組織 / 造血幹細胞 / 遺伝子ターゲティング / 血小板輸血 / 分化誘導 / トランスクリプトーム解析 |
|---|
| Research Abstract |
A large amount of platelets were generated from subcutaneous adipose tissues and preadipocytes in a highly-reproducible culture system using established culture media to differentiate of hematopoietic stem cells into platelets. Platelet functions were examined in peripheral platelets and cultured platelets. As compared with hematopoietic stem cell-derived platelets and platelets after 6-7hrs of blood drawing, adipose tissue-derived platelets showed higher functions in platelet activation and thrombus formation.
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Report
(4 results)
Research Products
(40 results)
