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Establishment of safety of HLA-haploidentical stem cell transplantation

Research Project

Project/Area Number 21591252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionHyogo Medical University

Principal Investigator

OGAWA Hiroyasu  兵庫医科大学, 医学部, 教授 (80194447)

Co-Investigator(Kenkyū-buntansha) TAMAKI Hiroya  兵庫医科大学, 医学部, 講師 (70416254)
IKEGAME Kazuhiro  兵庫医科大学, 医学部, 講師 (20372609)
FUJIOKA Tatsuya  兵庫医科大学, 医学部, 助教 (70403045)
YOSHIHARA Satoshi  兵庫医科大学, 医学部, 助教 (90461037)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords造血幹細胞移植 / HLA不適合移植 / 移植片対宿主病
Research Abstract

A prospective, multiinstitutional study for HLA-haploidentical reduced-intensity stem cell transplantation was performed, and all recipients achieved donor type engraftment in the phase I study. To treat steroid-resistant graft-versus-host disease(GVHD), we developed a novel therapy, "graft-versus-GVHD", in which patients with severe GVHD underwent re-transplantation using a graft from second donor. Furthermore, we established a murine model of MHC-haploidentical transplantation, in which recipients did not develop severe GVHD when receiving lower intensity of conditioning treatment. We found that host regulatory T cells were involved in the regulation of GVHD.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (92 results)

All 2012 2011 2010 2009

All Journal Article (46 results) (of which Peer Reviewed: 46 results) Presentation (42 results) Book (4 results)

  • [Journal Article] Intra-bone marrow transplantation of unwashed cord blood using reduced-intensity conditioning treatment : A phase I study2012

    • Author(s)
      Okada M, Yoshihara S, Taniguchi K, Ogawa H, et al.(12人中12番)
    • Journal Title

      Biology of Blood and Marrow Transplantation

      Volume: 18 Issue: 4 Pages: 633-639

    • DOI

      10.1016/j.bbmt.2008.12.508

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis : a study of the Osaka Lymphoma Study Group2012

    • Author(s)
      Wada N, Zaki MA, Kohara M, Ogawa H, et al.(12人中4番)
    • Journal Title

      Histopathology

      Volume: 60 Issue: 6 Pages: 924-932

    • DOI

      10.1111/j.1365-2559.2011.04161.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curative resection of double primary lung cancer after 15-month bortezomib administration2012

    • Author(s)
      Tamaki H, Hashimoto M, Naito Y, Ogawa H, et al.(7人中6番)
    • Journal Title

      Onkologie

      Volume: 35 Pages: 216-217

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells2012

    • Author(s)
      Eguchi R, Kubo S, Takeda H, Ogawa H, et al.(8人中6番)
    • Journal Title

      Carcinogenesis

      Volume: 33 Issue: 5 Pages: 969-975

    • DOI

      10.1093/carcin/bgs109

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human umbilical cord provides a significant source of unexpanded mesenchymal stromal cells2012

    • Author(s)
      Kikuchi-Taura A, Taguchi A, Ogawa H, et al.(13人中12人)
    • Journal Title

      Cytotherapy

      Volume: 14 Issue: 4 Pages: 441-450

    • DOI

      10.3109/14653249.2012.658911

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation2012

    • Author(s)
      Morishita S, Kaida K, Ikegame K, Ogawa H, et al.(9人中8人)
    • Journal Title

      Supportive Care in Cancer

      Volume: 20 Issue: 4 Pages: 821-829

    • DOI

      10.1007/s00520-011-1156-2

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Salvage haploidentical transplantation for graft failure using reduced-intensity conditioning2012

    • Author(s)
      Yoshihara S, Ikegame K, Taniguchi K, Ogawa H, et al.(13人中13番)
    • Journal Title

      Bone Marrow Transplantation

      Volume: 47 Issue: 3 Pages: 369-373

    • DOI

      10.1038/bmt.2011.84

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrabone marrow transplantation of unwashed cord blood using reduced-intensity conditioning treatment : a phase I study2012

    • Author(s)
      Okada M, et al
    • Journal Title

      Biology of blood and Marrow Transplantation

      Volume: 18 Issue: 4 Pages: 633-639

    • DOI

      10.1016/j.bbmt.2011.08.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of extramedullary relapse after haploidentical SCT for advanced AML/myelodysplastic syndrome2011

    • Author(s)
      Yoshihara S, Ikegame K, Kaida K, Ogawa H, et al.(11人中11番)
    • Journal Title

      Bone Marrow Transplantation

      Volume: (in press) Issue: 5 Pages: 669-676

    • DOI

      10.1038/bmt.2011.163

    • Year and Date
      2011-08-22
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated haploidentical SCT2011

    • Author(s)
      Yoshihara S, Maruya E, Taniguchi K, Ogawa H. et al.(17人中17番)
    • Journal Title

      Bone Marrow Transplantation

      Volume: (in press) Issue: 4 Pages: 508-515

    • DOI

      10.1038/bmt.2011.131

    • Year and Date
      2011-06-20
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic stem cell transplantation as treatment for heavily-treated, refractory acute graft-versus-host disease after HLA-mismatched stem cell transplantation2011

    • Author(s)
      Ikegame K, Yoshihara S, Taniguchi Y, Ogawa H, et al.(13人中13番)
    • Journal Title

      Experimental Hematology

      Volume: 39 Issue: 8 Pages: 880-890

    • DOI

      10.1016/j.exphem.2011.05.007

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for bone marrow transplantation in eculizumab-treated paroxysmal nocturnal hemoglobinuria2011

    • Author(s)
      Taniguchi K, Okada M, Yoshihara S, Ogawa H, et al.(11人中11番)
    • Journal Title

      International Journal of Hematology

      Volume: 94 Issue: 4 Pages: 403-407

    • DOI

      10.1007/s12185-011-0931-7

    • NAID

      10030265488

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dasatinib-induced rapid regression and complete molecular remission of multiple subcutaneous tumours presenting as relapsed chronic myeloid leukaemia after cord blood transplantation2011

    • Author(s)
      Nakata J, Okada M, Tamaki H, Ogawa H, e al.(9人中9番)
    • Journal Title

      Leuk Res

      Volume: 35 Issue: 12 Pages: 1658-1659

    • DOI

      10.1016/j.leukres.2011.07.005

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with nilotinib after imatinib failure in a CML patient with a four-way Ph chromosome translocation and point mutations in BCR/ABL gene2011

    • Author(s)
      Okada M, Satake A, Kaida K, Ogawa H, et al.(10人中10番)
    • Journal Title

      International Journal of Hematology

      Volume: 93 Issue: 2 Pages: 243-246

    • DOI

      10.1007/s12185-011-0769-z

    • NAID

      10029533342

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A decision analysis of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched sibling donor2011

    • Author(s)
      Kako S, Morita S, Sakamaki H, Ogawa H, et al.(20人中4番)
    • Journal Title

      Leukemia

      Volume: 25 Pages: 259-265

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presence of B-cell clones in T cell lymphoma2011

    • Author(s)
      Zaki MA, et al
    • Journal Title

      Eur J Hematol

      Volume: 86 Pages: 412-419

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of mycophenolate mofetil in patients received allogeneic hematopoietic stem cell transplantation in Japan2011

    • Author(s)
      Iida M, Takami A
    • Journal Title

      Int J Hematol

      Volume: 93 Issue: 4 Pages: 523-31

    • DOI

      10.1007/s12185-011-0817-8

    • NAID

      10029534696

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct antiglobulin test-negative autoimmune hemolytic anemia associated with HLA-haploidentical stem cell transplantation2011

    • Author(s)
      Nakata J, et al
    • Journal Title

      International Journal of Hematology

      Volume: 96 Issue: 4 Pages: 558-560

    • DOI

      10.1007/s12185-011-0833-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A decision analysis of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched sibling donor.2011

    • Author(s)
      Kako S, et al.
    • Journal Title

      Leukemia

      Volume: 25 Pages: 259-265

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kasayama S. Usefulness of glycated albumin as an indicator of glycemic control status in patients with hemolytic anemia.2011

    • Author(s)
      Koga M, et al.
    • Journal Title

      Clinica Chimica Acta

      Volume: 412 Pages: 253-257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-barr virus in diffuse large B-Cell lymphoma in immunocompetent patients in Japan is as low as in Western Countries.2011

    • Author(s)
      Wada N, et al.
    • Journal Title

      J Med Virol

      Volume: 83 Pages: 317-321

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with nilotinib after imatinib failure in a CML patient with a four-way Ph chromosome translocation and point mutations in BCR/ABL gene.2011

    • Author(s)
      Okada M, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 93 Pages: 243-246

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation : participation of host immune cells2010

    • Author(s)
      Satake A, Inoue T, Kubo S, Ogawa H., et al.(15人中15番)
    • Journal Title

      International Journal of Hematology

      Volume: 91 Issue: 3 Pages: 485-497

    • DOI

      10.1007/s12185-010-0545-5

    • NAID

      10026401388

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib2010

    • Author(s)
      Tamaki H, Naito Y, Lee-Kawabata M, Ogawa H., et al.(9人中9番)
    • Journal Title

      International Journal of Hematology

      Volume: 92 Issue: 4 Pages: 655-658

    • DOI

      10.1007/s12185-010-0710-x

    • NAID

      10027674126

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dasatinib is effective against optic nerve infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia2010

    • Author(s)
      Satake A, Okada M, Asada T, Ogawa H, et al.(8人中8番)
    • Journal Title

      Leukemia Lymphoma

      Volume: 51 Issue: 10 Pages: 1920-1922

    • DOI

      10.3109/10428194.2010.509453

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia : comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission2010

    • Author(s)
      Nishiwaki S, Inamoto Y, Sakamaki H, Ogawa H, et al.(19人中6番)
    • Journal Title

      Blood

      Volume: 116 Issue: 20 Pages: 4368-4375

    • DOI

      10.1182/blood-2010-02-269571

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of foscarnet for cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation from a related donor2010

    • Author(s)
      Asakura M, Ikegame K, Yoshihara S, Ogawa H. et al.(16人中16番)
    • Journal Title

      International Journal of Hematology

      Volume: 92 Issue: 2 Pages: 351-359

    • DOI

      10.1007/s12185-010-0657-y

    • NAID

      10026712482

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatosplenic alphabeta T cell lymphoma2010

    • Author(s)
      Nagai Y, Ikegame K, Mori M, Ogawa H, et al.(14人中13番)
    • Journal Title

      Int J Clin Oncol

      Volume: 15 Issue: 2 Pages: 215-219

    • DOI

      10.1007/s10147-010-0028-y

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation : participation of host immune cells.2010

    • Author(s)
      Satake A, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 91 Pages: 485-497

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia : comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission.2010

    • Author(s)
      Nishiwaki S, et al.
    • Journal Title

      Blood

      Volume: 116 Pages: 4368-4375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse large B-cell lymphoma in the spinal epidural space : A study of the Osaka Lymphoma Study Group2010

    • Author(s)
      Wada N, et al.
    • Journal Title

      Pathol Res Pract

      Volume: 206 Pages: 439-444

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral blood stem cell versus bone marrow transplantation from HLA-identical sibling donors in patients with leukemia : a propensity score-based comparison from the Japan Society for Hematopoietic Stem Cell Transplantation registry2010

    • Author(s)
      Nagafuji K, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 91 Pages: 855-864

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD318/CUB-domain-containing protein 1 expression on cord blood hematopoietic progenitors2010

    • Author(s)
      Takeda H, et al.
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 1 Pages: 497-501

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib.2010

    • Author(s)
      Tamaki H, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 92 Pages: 655-658

    • NAID

      10027674126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dasatinib is effective against optic nerve infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia.2010

    • Author(s)
      Satake A, et al.
    • Journal Title

      Leukemia Lymphoma

      Volume: 51 Pages: 1920-1922

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation : participation of host immune cells.2010

    • Author(s)
      Satake A, et al
    • Journal Title

      International Journal if Hematology 91

      Pages: 485-497

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatosplenic alphabeta T cell lymphoma.2010

    • Author(s)
      Nagai Y, et al.
    • Journal Title

      Int J Clin Oncol 15

      Pages: 215-219

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphous lymphoproliferative disease : a clinicopathological analysis.2010

    • Author(s)
      Nakamichi N
    • Journal Title

      Virchow Archives 456

      Pages: 269-276

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular detection of AML1-MTG8-positive cells in peripheral blood from a patient with isolated extramedullary relapse of t(8 ; 21) acute myeloid leukemia2009

    • Author(s)
      Tamaki H, Yoshihara S, Fujioka T, Ogawa H, et al.(6人中6番)
    • Journal Title

      Leukemia

      Volume: 23 Issue: 2 Pages: 424-426

    • DOI

      10.1038/leu.2008.220

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia : t(8 ; 21) and inv(16) represent different clinical outcomes2009

    • Author(s)
      Kuwatsuka Y, Miyamura K, Suzuki R, Ogawa H, et al.(14人中6番)
    • Journal Title

      Blood

      Volume: 113 Issue: 9 Pages: 2096-2103

    • DOI

      10.1182/blood-2008-03-145862

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and risk factor of early bacterial infections after unrelated cord blood transplantation2009

    • Author(s)
      Yazaki M, Atsuta Y, Kato K, Ogawa H, et al.(17人中7番)
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 15 Pages: 439-446

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes(Lymphoepithelioid B-cell lymphoma): A study of Osaka Lymphoma Study Group2009

    • Author(s)
      Wada N, Ikeda J, Kohara M, Ogawa H, et al.(11人中4番)
    • Journal Title

      Virchow Archives

      Volume: 455 Issue: 3 Pages: 285-293

    • DOI

      10.1007/s00428-009-0827-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular detection of AML1-MTG8-positive cells in peripheral blood from a patient with isolated extramedullary relapse of t(8 ; 21)acute myeloid leukemia.2009

    • Author(s)
      Tamaki H, et al.
    • Journal Title

      Leukemia 23

      Pages: 424-426

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia : t(8 ; 21)and inv(16)represent different clinical outcomes2009

    • Author(s)
      Kuwatsuka Y, et al.
    • Journal Title

      Blood 113

      Pages: 2096-2103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes(Lymphoepithelioid B-cell lymphoma): A study of Osaka Lymphoma Study Group.2009

    • Author(s)
      Wada N, et al.
    • Journal Title

      Virchow Archives 455

      Pages: 285-293

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and Risk factor of Early Bacterial Infections after Unrelated Cord Blood Transplantation.2009

    • Author(s)
      Yazaki M, et al.
    • Journal Title

      Biol Blood Marrow Transplant 15

      Pages: 439-446

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cord blood stem cell transplantation : from the bench to the bed, Intra-bone marrow transplantation of unwashed cord blood using reduced-intensity conditioning treatment2012

    • Author(s)
      Ogawa H.
    • Organizer
      第34回日本造血細胞移植学会
    • Place of Presentation
      大阪
    • Year and Date
      2012-02-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Cord blood stem cell transplantation : from the bench to the bed, Intrabone marrow transplantation of unwashed cord blood using reduced-intensity conditioning treatment2012

    • Author(s)
      Ogawa H
    • Organizer
      第34回日本造血細胞移植学会
    • Place of Presentation
      大阪(Presidential Symposium)(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] (JSA-EHA Joint Symposium-Stem Cell Source) Unmanipulated HLA-haploidentical stem cell transplantation2011

    • Author(s)
      Ogawa H.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Unmanipulated HLA-haploidentical stem cell transplantation (JSA-EHA Joint Symposium-Stem Cell Source)2011

    • Author(s)
      Ogawa H
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Host regulatory T cells contribute to the regulation of GVHD in murine MHC haploidentical BMT models2011

    • Author(s)
      井上貴之、池亀和博、吉原哲、海田勝仁、谷口享子、玉置広哉、藤岡龍哉、岡田昌也、加藤るり、山本庸子、相馬俊裕、小川啓恭
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 移植後再発/拒絶に対する再移植としての夫婦間造血幹細胞移植の可能性2011

    • Author(s)
      池亀和博, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 移植前処置におけるATG (Rresenius) 8mg/kg投与時の薬物動態2011

    • Author(s)
      海田勝仁, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 顆粒球の動員および採取効率の検討2011

    • Author(s)
      池本純子, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] HLA半合致ドナーからのreduced intesnsity stem cell transplantation後、寛解到達と同時に軸索障害性末梢神経障害により完全下半身麻痺を来したリンパ芽球性リンパ腫の一例2011

    • Author(s)
      川上学, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄内臍帯血ミニ移植-臨床第1相試験結果報告2011

    • Author(s)
      岡田昌也, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 兵庫医科大学における造血幹細胞移植施行予定で抜歯した患者の術後経過2011

    • Author(s)
      河田尚子, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Homozygous HLA患者へのHLA不適合半合致移植では拒絶リスクが高い2011

    • Author(s)
      石川貴己, et al.
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unmanipulated haploidentical stem cell transplantation using myeloablative or reduced-intensity preconditioning regimen.2011

    • Author(s)
      Ikegame K, et al.
    • Organizer
      2011 BMT Tandem Meetings.
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unmanipulated HLA-haploidentical(2-3 antigen-mismatched) stem cell transplantation using myeliablative or reduced-intensity preconditioning regimen2011

    • Author(s)
      Kaida K, Ikegame K, Yoshihara S, Taniguchi K, Ishii S, Kato R, Inoue T, Okada M, Tamaki H, Fujioka T, Soma T, Ogawa H.
    • Organizer
      The 53th annual meeting of the American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Haplo-identical HCT from family members2011

    • Author(s)
      Ogawa H.
    • Organizer
      The 1st international scientific symposium on hematopoietic stem cell transplantation in emerging countries
    • Place of Presentation
      Hanoi, Bietnam
    • Related Report
      2011 Final Research Report
  • [Presentation] Haplo-identical HCT from family members2011

    • Author(s)
      Ogawa H, Haplo-identical HCT from family members
    • Organizer
      The 1st international scientific symposium on hematopoietic stem cell transplantation in emerging countries
    • Place of Presentation
      Hanoi, Bietnam(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Unmanipulated HLA-haploidentical (2-3 antigen-mismatched) stem cell transplantation using myeliablative or reduced-intensity preconditioning regimen2011

    • Author(s)
      Kaida K, et al
    • Organizer
      The 53th annual meeting of the American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prospective isolation and functional characterization of human bone marrow-derived hematopoietic stem cell-supportive mesenchymal stromal cells.2010

    • Author(s)
      Sasaki Y, et al.
    • Organizer
      The 52th annual meeting of the American Society of Hematology
    • Place of Presentation
      Orlando
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanism of marked reduction in the severity of graft-versus-host disease by reduced-intensity conditioning in murine MHC-haploidentical BMT model.2010

    • Author(s)
      Inoue T, et al.
    • Organizer
      The 52th annual meeting of the American Society of Hematology
    • Place of Presentation
      Orlando
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] One-HLA-antigen-mismatched related hematopoietic stem- cell transplantation using graft-versus-host disease prophylaxis with methylpredonisolone.2010

    • Author(s)
      Kato R, et al.
    • Organizer
      The 15th Congress of Asia-Pacific Blood and Marrow Transplantation
    • Place of Presentation
      Phuket
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Clinical significance of WT1 mRNA expression level in patients with myelodysplastic syndrome (MDS)2010

    • Author(s)
      Nannya Y, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] High risk of graft rejection in cases with HLA anitibodies undergoing haploidentical SCT without TCD2010

    • Author(s)
      吉原哲, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Disseminated adenovirus disease after HLA-haplidentical stem cell trans plantation2010

    • Author(s)
      谷口享子, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prospective isolation and functional characterization of human bone marrow-rerived MSCs2010

    • Author(s)
      Matsuoka Y, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparison of ATG with Thymoglogulin in the lymphocyte recovery after haploidentical SCT2010

    • Author(s)
      池亀和博, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Favorable outcome of haploidentical SCT with a novel conditioning regimen following graft rejection2010

    • Author(s)
      小田原聡一, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Phamacokinetics of itoconazole in HSCT patients receiving IV ITCZ 200mg followed by capsule 400mg2010

    • Author(s)
      Kaida K, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科における成人骨髄内臍帯血ミニ移植(静脈内輸注法との比較)2010

    • Author(s)
      岡田昌也, ら
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] オーラルマネジメントにより著明な歯肉の炎症を改善できた急性骨髄性白血病の1例2010

    • Author(s)
      蔵下舞, ら
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 同種末梢血幹編胞採取血液に含まれる赤血球量の検討2010

    • Author(s)
      池本純子, ら
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 同種造血幹細胞移植後における血清可溶性I1-2受容体レベルによる急性GVHDのモニタリング2010

    • Author(s)
      海田勝仁, ら
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 単回HLA半合致血縁者ミニ移植の生命予後へ影響を及ぼす因子の解析2010

    • Author(s)
      玉置広哉, ら
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Unmanipulated haploidentical stem cell transplantation using myeloabla tive or reduced-intensity preconditioning regimen.2010

    • Author(s)
      Ikegame K, et al
    • Organizer
      The 36th Annual Meeting of the European Group for Blood and Marrow Transplantation
    • Place of Presentation
      ウイーン
    • Related Report
      2009 Annual Research Report
  • [Presentation] 同種造血細胞移植後の急性GVHDと制御性T細胞の動態との関連性-HLA半合致移植を中心とした解析2009

    • Author(s)
      藤岡龍哉, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 我が国における血縁同種造血幹細胞移植でのMycophenolate Mofetil(MMF)使用実態全国調査結果報告2009

    • Author(s)
      飯田美奈子, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Our experience of multiple(three times and more)allogeneic stem cell transplantation2009

    • Author(s)
      池亀和博, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ph陽性白血病髄外再発症例に対するダサチニブの効果2009

    • Author(s)
      岡田昌也, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 造血幹細胞移植の経過中に、Trichosporon asahiiによる播種性トリコスポロン症を合併した症例2009

    • Author(s)
      加藤るり, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスMHCハプロミスマッチGVHDモデルはGVHDを抑制しGVL効果を発揮する2009

    • Author(s)
      佐竹敦志, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] HLA不適合血縁移植、臍帯血移植54例におけるHHV-6血症の解析2009

    • Author(s)
      玉置広哉, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 造血幹細胞移植後の骨髄抑制に鉄過剰症が関与したと思われる1例2009

    • Author(s)
      中田潤, ら
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Frequent monitoring of Wilms' tumor gene(WT1)expression levels in peripheral blood for early diagnosis of acute leukemia relapse after allogeneic stem cell transplantation.2009

    • Author(s)
      Kato R, et al.
    • Organizer
      The 14th congress of the European Hematology Association
    • Place of Presentation
      Berlin
    • Related Report
      2009 Annual Research Report
  • [Book] GVH反応とGVL反応におけるT細胞の異なった役割、臨床免疫・アレルギー科2011

    • Author(s)
      池亀和博、小川啓恭
    • Publisher
      科学評論社
    • Related Report
      2011 Final Research Report
  • [Book] HLA半合致移植、血液疾患最新の治療2011

    • Author(s)
      池亀和博、小川啓恭
    • Publisher
      南江堂
    • Related Report
      2011 Annual Research Report
  • [Book] 薬学生のための臨床実習マニュアル2011

    • Author(s)
      松田重三, ら
    • Total Pages
      335
    • Publisher
      医学評論社
    • Related Report
      2010 Annual Research Report
  • [Book] HLA半合致移植、血液疾患最新の治療2010

    • Author(s)
      池亀和博、小川啓恭
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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