| Project/Area Number |
21591254
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
DOI Takahiro 独立行政法人理化学研究所, 生体情報統合技術開発チーム, サブチームリーダー (60227684)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MISE Setsuko 独立行政法人理化学研究所, 生体情報統合技術開発チーム, 開発研究員 (00269052)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | NF-kB / RelA / c-Rel / Hematopoiesis / Lym / phocytes / Macrophages Maturation / Apoptosis / Lymphocyte / Macrophage / Maturation arrest / Apopotsis / 造血機構 / リンパ球 / マクロファージ |
|---|
| Research Abstract |
We demonstrated that RelA and c-Rel were essential for regulation of cell-autonomous differentiation factors in hematopoiesis, because stem cells of lymphocytes and macrophages lacking RelA and c-Rel do not develop even in normal hematopoietic environment. And it was demonstrated that RelA and c-Rel functioned coordinately, because mice deficient of both of them showed pancytopenia, although mice lacking each of them did not. The main role of RelA and c-Rel in development of lymphocytes and macrophages cells from apoptosis. And beyond imagination, it was also demonstrated that RelA and c-Rel played the critical roles on development, not of lymphocytes and macrophages but also of megakaryocytes and erythrocytes.
|
