• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the susceptible genes of antiphospholipid syndrome and systemic lupus erythematosus.

Research Project

Project/Area Number 21591258
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionHokkaido University

Principal Investigator

HORITA Tetsuya  北海道大学, 北海道大学病院, 講師 (50399929)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords一塩基多型 / 疾患感受性遺伝子 / 全身性エリテマトーデス / 抗リン脂質抗体症候群
Research Abstract

To explore the genetic background of antiphospholipid syndrome and systemic lupus erythematosus, the analysis of single nucleotide polymorphisms (SNPs) was performed after the establishment of database of APS and SLE in Japanese population. TNFAIP3 SNP was associated with SLE in Japanese population. In addition, various lupus susuceptible genes were found by multicenter genome wide association study.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (28 results) (of which Peer Reviewed: 25 results) Presentation (10 results) Book (1 results)

  • [Journal Article] genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K
    • Journal Title

      PLoS Genetics

      Volume: 8(1)

    • NAID

      120005906866

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events2012

    • Author(s)
      K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 64(2) Pages: 504-512

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired expression of Act1mRNA in B cells of patients with Sjögren's syndrome2012

    • Author(s)
      中川靖子, 片岡浩, 栗田崇史, 中川久子, 保田晋助, 堀田哲也, 渥美達也, 小池隆夫
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 35 Issue: 1 Pages: 75-80

    • DOI

      10.2177/jsci.35.75

    • NAID

      10030465739

    • ISSN
      0911-4300, 1349-7413
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events2012

    • Author(s)
      Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 64 Issue: 2 Pages: 504-512

    • DOI

      10.1002/art.33340

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis2011

    • Author(s)
      Hashimoto T, Yasuda S, Koide H, Kataoka H, Horita T, Atsumi T, Koike T
    • Journal Title

      Arthritis Res Ther

      Volume: 13(5)

    • NAID

      120003945421

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B Virus Reactivation by Immunosuppressive Therapy in Patients with Autoimmune Diseases : Risk Analysis in Hepatitis B Surface Antigen-negative Cases2011

    • Author(s)
      Kato M, Atsumi T, Kurita T, Odani T, Fujieda Y, Otomo K, Horita T, Yasuda S, Koike T
    • Journal Title

      J Rheumatol

      Volume: 38(10) Pages: 2209-2214

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases : report of five cases and a literatural review2011

    • Author(s)
      Kato M, Kataoka H, Odani T, Fujieda Y, Otomo K, Oku K, Horita T, Yasuda S, Atsumi T, Tsujino I, Nishimura M, Koike T
    • Journal Title

      Lupus

      Volume: 20(10) Pages: 1047-1056

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus2011

    • Author(s)
      Fujieda Y, Kataoka H, Odani T, Otomo K, Kato M, Fukaya S, Oku K, Horita T, Yasuda S, Atsumi T, Koike T
    • Journal Title

      Mod Rheumatol

      Volume: 21(3) Pages: 276-281

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin2011

    • Author(s)
      Bohgaki M, Matsumoto M, Atsumi T, Kondo T, Yasuda S, Horita T, Nakayama KI, Okumura F, Hatakeyama S, Koike T
    • Journal Title

      J Cell Mol Med

      Volume: 15(1) Pages: 141-151

    • NAID

      120003660581

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膠原病に伴う血栓症2011

    • Author(s)
      清水裕香、堀田哲也
    • Journal Title

      内科

      Volume: 107 Pages: 631-635

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 関節リウマチ患者における従来の非ステロイド性消炎鎮痛薬からcyclooxygenase-2選択的阻害薬セレコキシブへの切り替えによる臨床効果の検討2011

    • Author(s)
      加藤将, 栗田崇史, 小谷俊雄, 藤枝雄一郎,大友耕太郎,堀田哲也,保田晋助, 渥美達也, 小池隆夫
    • Journal Title

      新薬と臨牀

      Volume: 60 Pages: 1377-1344

    • Related Report
      2011 Annual Research Report
  • [Journal Article] The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases : report of five cases and a literatural review2011

    • Author(s)
      Kato M, Kataoka H, Odani T, Fujieda Y, Otomo K, Oku K, Horita T, Yasuda s, Atsumi T, Tsujino I, Nishimura M, Koike T
    • Journal Title

      Lupus

      Volume: 20 Issue: 10 Pages: 1047-1056

    • DOI

      10.1177/0961203311403347

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus.2011

    • Author(s)
      Fujieda Y, et al
    • Journal Title

      Mod Rheumatol

      Volume: Jan 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Expression of Phospholipid Scramblase 1 in Monocytes from Patients with Systemic Lupus Erythematosus2010

    • Author(s)
      Suzuki E, Amengual O, Atsumi T, Oku K, Hashimoto T, Kataoka H, Horita T, Yasuda S, Ieko M, Fukushima K, Koike T
    • Journal Title

      J Rheumatol

      Volume: 37(8) Pages: 1639-1645

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association of a non-synonymous SNP in the TNFAIP3 gene with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y and Yamamoto K
    • Journal Title

      Arthritis Rheum 2010

      Volume: 62(2) Pages: 574-579

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of phospholipid scramblase 1 in monocytes from patients with systemic lupus erythematosus.2010

    • Author(s)
      Suzuki E, et al
    • Journal Title

      J Rheumatol

      Volume: 37 Pages: 1639-1645

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2010

    • Author(s)
      Shimane K, et al
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 574-579

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, et al
    • Journal Title

      Arthritis Rheum 62

      Pages: 574-579

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicked・2-glycoprotein I binds angiostatin4.5 (plasminogen kringle 1-5) and attenuates its anti-angiogenic property2009

    • Author(s)
      Nakagawa H, Yasuda S, Matsuura E, Kobayashi K, Ieko M, Kataoka H, Horita T, Atsumi T, and Koike T
    • Journal Title

      Blood

      Volume: 114(12) Pages: 2553-2559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of phosphatidylserine dependent antiprothrombin antibody on thrombin generation2009

    • Author(s)
      Sakai Y, Atsumi T, Ieko M, Amengual O, Furukawa S , Furusaki A, Bohgaki M, Kataoka H, Horita T, Yasuda S and Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 60(8) Pages: 2457-2467

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement activation in patients with primary antiphospholipid syndrome2009

    • Author(s)
      Oku K, Atsumi T, Bohgaki M, Amengual O, Kataoka H, Horita T, Yasuda S, Koike T
    • Journal Title

      Ann Rheum Dis

      Volume: 68(11) Pages: 1030-1035

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis : relationship between clinical benefits and intensity of immunosuppression2009

    • Author(s)
      Bohgaki T, Atsumi T, Bohgaki M, Furusaki A, Kondo M, Sato-Matsumura KC, Abe R, Kataoka H, Horita T, Yasuda S, Amasaki Y, Nishio M, Sawada K, Shimizu H, Koike T
    • Journal Title

      J Rheumatol

      Volume: 36(6) Pages: 1240-1248

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] STAT4 single nucleotide polymorphism, rs7574865 G/T, as a risk for antiphospholipid syndrome2009

    • Author(s)
      Horita T, Atsumi T, Yoshida N, Nakagawa H, Kataoka H, Yasuda S, Koike T
    • Journal Title

      Ann Rheum Dis

      Volume: 68(8) Pages: 1366-1367

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Splenic Volume in Systemic Lupus Erythematosus2009

    • Author(s)
      Harris A, Kamishima T, Horita T, Atsumi T, Fujita N, Omatsu T, Onodera Y, Terae S, Koike T, Shirato H
    • Journal Title

      Lupus

      Volume: 18(12) Pages: 1119-1120

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] STAT4 single nucleotide polymorphism, rs7574865 G/T, as a risk for antiphospholipid syndrome2009

    • Author(s)
      Horita T, Atsumi T, Yoshida N, et al
    • Journal Title

      Ann Rheum Dis 68

      Pages: 1366-1367

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complement activation in patients with primary antiphospholipid syndrome2009

    • Author(s)
      Oku K, Atsumi T, Bohgaki M, et al
    • Journal Title

      Ann Rheum Dis 68

      Pages: 1030-1035

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      堀田哲也
    • Journal Title

      今日の治療指針2009:「血管炎症候群」(医学書院)

      Pages: 615-617

    • Related Report
      2009 Annual Research Report
  • [Presentation] ワークショップ3「自己抗体」:抗リン脂質抗体症候群と遺伝子多型2011

    • Author(s)
      堀田哲也
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗リン脂質抗体患者におけるAGTRL1とPRKCH遺伝子多型の解析2011

    • Author(s)
      堀田哲也、中川久子、小谷俊雄、藤枝雄一郎、大友耕太郎、加藤将、保田晋助、渥美達也、小池隆夫
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗リン脂質抗体症候群と遺伝子多型2011

    • Author(s)
      堀田哲也
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      京王プラザホテル、東京(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗リン脂質抗体患者におけるAGTRL1とPRKCH遺伝子多型の解析2011

    • Author(s)
      堀田哲也、中川久子、小谷俊雄、藤枝雄一郎、大友耕太郎、加藤将、保田晋助、渥美達也、小池隆夫
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      ピアホテル、神戸国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel Lupus Susceptible Gene Polymorphisms in Patients with Sjogren's Syndrome in Japanese Population.2010

    • Author(s)
      Horita T, et al
    • Organizer
      The 74th annual meeting of the American College of Rheumatology
    • Place of Presentation
      米国アトランタ
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel Lupus Susceptible Gene Polymorphisms in Patients with Sjogren's Syndrome in Japanese Population2010

    • Author(s)
      Horita T, Nakagawa H, Kurita T, Odani T, Fujieda Y, Otomo K, Kato M, Yasuda S, Atsumi T, Koike T
    • Organizer
      The 74th Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Atlanta, Georgia, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Lupus Susceptible Gene Polymorphisms in Patients with Antiphospholipid Syndrome in Japanese Population2010

    • Author(s)
      Horita T, Nakagawa H, Oku K, Kataoka H, Yasuda S, Atsumi T, Koike T
    • Organizer
      The 13th International Congress on Antiphospholipid Antibodies
    • Place of Presentation
      Galveston, Texas, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Lupus Susceptible Gene Polymorphisms in Patients with Antiphospholipid Syndrome2009

    • Author(s)
      Horita T, Nakagawa N, Oku K, et al
    • Organizer
      American College of Rheumatology 73^<rd> Annual Scientific Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lupus Susceptible Gene Polymorphisms in Patients with Antiphospholipid Syndrome2009

    • Author(s)
      Horita T, Nakagawa N, Oku K, Kataoka H, Yasuda S, Atsumi T, Koike T
    • Organizer
      The 73rd Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗リン脂質抗体症候群患者における全身性エリテマトーデスの疾患感受性遺伝子の多型解析2009

    • Author(s)
      堀田哲也、中川久子、片岡浩、保田晋助、渥美達也、小池隆夫
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Related Report
      2011 Final Research Report
  • [Book] 「血管炎症候群」、今日の治療指針2009

    • Author(s)
      堀田哲也
    • Publisher
      山口徹、北原光夫、福井次矢編、医学書院
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi