| Project/Area Number |
21591259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hirosaki University |
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Principal Investigator |
IMAIZUMI Tadaatsu 弘前大学, 医学(系)研究科(研究院), 教授 (90232602)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO You 弘前大学, 医学(系)研究科(研究院), 研究員 (10312498)
ISHIBASHI Yasuyuki 弘前大学, 医学(系)研究科(研究院), 教授 (80292142)
YOSHIDA Hidemi 弘前大学, 医学(系)研究科(研究院), 講師 (40201008)
MATSUMIYA Tomoho 弘前大学, 医学(系)研究科(研究院), 助教 (30344592)
SATOH Kei 弘前大学, 事務局, 学長 (20125438)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | リウマチ / ループス腎炎 / RIG-I / MDA5 / 細胞質RNA受容体 / 慢性炎症 / TLR3 / IFN-β / DEC2 / poly IC / ISG20 / Th1 / RIG-1 / microRNA / IFN-γ / TNF-α / CCL5 / microRNA-155 / inflammation |
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| Research Abstract |
Retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are TNF-α-inducible RNA receptors in cytoplasm. The expression of RIG-I and MDA5 are induced by viral infection, and are increased in chronic inflammatory diseases such as rheumatoid arthritis and lupus nephritis which can be triggered or worsened by viral infections. Knockdown of RIG-I and/or MDA5 resulted in the induction of inflammatory cytokines，and RIG-I and MDA5 can be molecules which can be new therapeutic targets.
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