Development of therapeutic strategies for RA targeting TNF-α-inducible RNA receptors in cytoplasm
Project/Area Number |
21591259
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Hirosaki University |
Principal Investigator |
IMAIZUMI Tadaatsu 弘前大学, 医学(系)研究科(研究院), 教授 (90232602)
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Co-Investigator(Kenkyū-buntansha) |
ISHIGURO You 弘前大学, 医学(系)研究科(研究院), 研究員 (10312498)
ISHIBASHI Yasuyuki 弘前大学, 医学(系)研究科(研究院), 教授 (80292142)
YOSHIDA Hidemi 弘前大学, 医学(系)研究科(研究院), 講師 (40201008)
MATSUMIYA Tomoho 弘前大学, 医学(系)研究科(研究院), 助教 (30344592)
SATOH Kei 弘前大学, 事務局, 学長 (20125438)
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Project Period (FY) |
2009 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | リウマチ / ループス腎炎 / RIG-I / MDA5 / 細胞質RNA受容体 / 慢性炎症 / TLR3 / IFN-β / DEC2 / poly IC / ISG20 / Th1 / RIG-1 / microRNA / IFN-γ / TNF-α / CCL5 / microRNA-155 / inflammation |
Research Abstract |
Retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are TNF-α-inducible RNA receptors in cytoplasm. The expression of RIG-I and MDA5 are induced by viral infection, and are increased in chronic inflammatory diseases such as rheumatoid arthritis and lupus nephritis which can be triggered or worsened by viral infections. Knockdown of RIG-I and/or MDA5 resulted in the induction of inflammatory cytokines,and RIG-I and MDA5 can be molecules which can be new therapeutic targets.
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Melanoma Differentiation-Associated Gene 5 Regulates the Expression of a Chemokine CXCL10 in Human Mesangial Cells: Implications for Chronic Inflammatory Renal Diseases2012
Author(s)
Imaizumi T, Aizawa-Yashiro T, Tsuruga K, Tanaka H, Matsumiya T, Yoshida H, Tatsuta T, Xing F, Hayakari R, Satoh K
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 228
Issue: 1
Pages: 17-26
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Journal Article] Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells.2011
Author(s)
Okabayashi T, Kojima T, Masaki T, Yokota SI, Imaizumi T, Tsutsumi H, Himi T, Fujii N, Sawada N
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Journal Title
Virus Res
Volume: 160(1-2)
Issue: 1-2
Pages: 360-366
DOI
Related Report
Peer Reviewed
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[Journal Article] IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells2010
Author(s)
Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, Tsuruga K, Aizawa-Yashiro T, Hayakari R, Inoue I, Ito E, Satoh K
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Journal Title
Am J Nephrol
Volume: 32
Issue: 5
Pages: 462-468
DOI
Related Report
Peer Reviewed
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[Journal Article] IFN-γ and TNF-a synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells.2010
Author(s)
Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, Tsuruga K, Aizawa-Yashiro T, Hayakari R, Inoue I, Ito E, Satoh K.
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Journal Title
Am J Nephrol
Volume: 32
Pages: 462-468
Related Report
Peer Reviewed
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[Journal Article] Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-γ-stimulated CXCL9-11 production in intestinal epithelial cells2009
Author(s)
Kawaguchi S, Ishiguro Y, Imaizumi T, Mori F, Matsumiya T, Yoshida H, Ota K, Sakuraba H, Yamagata K, Sato Y, Tanji K, Haga T, Wakabayashi K, Fukuda S, Satoh K
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Journal Title
Immunol Lett
Volume: 123(1)
Issue: 1
Pages: 9-13
DOI
Related Report
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[Journal Article] Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-γ-stimulated CXCL9-11 production in intestinal epithelial cells.2009
Author(s)
Kawaguchi S, Ishiguro Y, Imaizumi T, Mori F, Matsumiya T, Yoshida H, Ota K, Sakuraba H, Yamagata K, Sato Y, Tanji K, Haga T, Wakabayashi K, Fukuda S, Satoh K
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Journal Title
Immunol Lett 123
Pages: 9-13
Related Report
Peer Reviewed
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