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Pathogenic role of newly identified regulatory molecule in autoimmune arthritis

Research Project

Project/Area Number 21591261
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionUniversity of Tsukuba

Principal Investigator

MATSUMOTO Isao  筑波大学, 医学医療系, 准教授 (30343081)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリウマチ学 / 関節リウマチ / TNFa / TIARP / シトルリン化蛋白 / GPI / 自己抗体 / ACPA / glucose-6-phosphate isomerase / TNFα / STEAP4
Research Abstract

1)TIARP-/-mice developed spontaneous arthritis, had high serum levels of IL-6, increased CD11b+ cell count in the spleen, and showed enhanced TNF-induced IL-6 expression in macrophages. Sustained degradation of IkBa with dysregulated apoptosis was also noted in TIARP-/-macrophages, and they showed increased IL-6-induced STAT3 phosphorylation. These findings suggested that TIARP is a negative regulator in arthritis by suppressing IL-6 production, its signaling and TNFa-induced NF-kB signaling result in enhanced apoptosis in macrophages. 2)Nine cyclic citrullinated GPI peptides (CCG-1-9) were constructed. Samples were obtained from patients with RA (n=208), healthy subjects (n=174) and other autoimmune diseases (n=202). Anti-CCG-2, 4, 7 Abs were detected in about 30.0% patients with RA, and these Abs were very specific of RA (specificity 99%). Anti-CCG-2, 4, 7 Abs were correlated with anti-CCP, CEP-1 and the presence of HLA-DRB1 SE allele. Treatment with TNF antagonists significantly reduced the levels of anti-CCG-2, 7, suggesting possible diagnostic and activity marker of RA.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (73 results)

All 2012 2011 2010 2009 Other

All Journal Article (33 results) (of which Peer Reviewed: 9 results) Presentation (9 results) Book (27 results) Remarks (4 results)

  • [Journal Article] Interleukine-6 regulates anti-arthritic effect of methotrexate via the reduction of SLC19A1 expression in mouse arthritis model2012

    • Author(s)
      Hashizume M, Yoshida H, Tanaka K, SuzukiM, Matsumoto I, Sumida T, Mihara M
    • Journal Title

      Arthritis Research & Therapy

      Volume: (in press)

    • NAID

      120007137138

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population2012

    • Author(s)
      Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, TsuchiyaN.
    • Journal Title

      Lupus

      Volume: (in press)

    • NAID

      120007136865

    • Related Report
      2011 Final Research Report
  • [Journal Article] Six-transmembrane epithelialantigen of prostate4(STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis2012

    • Author(s)
      Tanaka Y, *Matsumoto I, Iwanami K, Inoue A, Umeda N, Tanaka Y, Sugihara M, Hayashi T, Ito S, Sumida T
    • Journal Title

      Clin. Exp. Rheumatol

      Volume: 30 Pages: 99-102

    • Related Report
      2011 Final Research Report
  • [Journal Article] Generation and functional analysis of monoclonal antibodies against the second extracellular loop of human M3 muscarinic acetylcholine receptor2012

    • Author(s)
      Tsuboi H, Nakamura Y, Iizuka M, Matsuo N, Matsumoto I, Sumida T.
    • Journal Title

      Mod.Rheumatol

      Volume: 22 Pages: 264-271

    • NAID

      10030615200

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of T-bet generegulates murine autoimmune arthritis2012

    • Author(s)
      Kondo Y, Iizuka M, Wakamatsu E, Yao Z, Tahara M, Tsuboi H, Sugihara M, Hayashi T, Yoh K, Takahiashi S, Matsumoto I, andSumida T
    • Journal Title

      Arthritis Rheum

      Volume: 64 Pages: 162-72

    • Related Report
      2011 Final Research Report
  • [Journal Article] Six-transmembraneepithelial antigen of prostate4(STEAP4) is TNFalpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis2012

    • Author(s)
      Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S and Sumida T
    • Journal Title

      Mod.Rheumatol

      Volume: 22 Pages: 128-36

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of T-bet gene regulates murine autoimmune arthritis2012

    • Author(s)
      Kondo Y
    • Journal Title

      Arthritis Rheum.

      Volume: 64:162-72 Pages: 162-172

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Six-transmembrane epithelial antigen of prostate4(STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis2012

    • Author(s)
      Tanaka Y
    • Journal Title

      Clin.Exp.Rheumatol.

      Volume: 30 Pages: 99-102

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Six-transmembrane epithelial antigen of prostate4(STEAP4) is TNFalpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis2012

    • Author(s)
      Tanaka Y
    • Journal Title

      Mod.Rheumatol

      Volume: 22 Issue: 1 Pages: 128-136

    • DOI

      10.1007/s10165-011-0475-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NK1.1+ gdT cellsattenuates IL-18 plus IL-2-induced murine interstitial lung disease. Am. J. Res2011

    • Author(s)
      Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S and Sumida T
    • Journal Title

      Cell. Mol.Biol

      Volume: 45 Pages: 659-66

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cumulative Association of Eight Susceptibility Genes with Systemic Lupus Erythematosus in a Japanese Female Population2011

    • Author(s)
      Koga M, Kawasaki A, Ito I, Furuya T, OhashiJ, Kyogoku C, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Hashimoto H, Sumida T and Tsuchiya N
    • Journal Title

      J Hum Genet

      Volume: 56 Pages: 503-507

    • NAID

      10030660079

    • Related Report
      2011 Final Research Report
  • [Journal Article] Importance of serine 727 phosphorylated STAT1 in IFNgamma-inducedsignaling and apoptpsis of human salivarygland cells2011

    • Author(s)
      Tsuboi H, Wakamatsu E, Iizuka M, Nakamura Y, Sugihara M, Suzuki T, Ogishima H, Hayashi T, Goto D, Ito S, Matsumoto I, Sumida T
    • Journal Title

      Int. J. Rheum Dis.

      Volume: 14 Pages: 86-91

    • Related Report
      2011 Final Research Report
  • [Journal Article] Activation of natural killer Tcells by α-carba-GalCer (RCAI-56), a novelsynthetic glycolipid ligand, suppresses murine collagen-induced arthritis2011

    • Author(s)
      Yoshiga Y, Goto D, Segawa S, Horikoshi M, Hayashi T, Matsumoto I, Ito S, Taniguchi Sand Sumida T
    • Journal Title

      Clin. Exp. Immunol

      Volume: 164 Pages: 236-247

    • Related Report
      2011 Final Research Report
  • [Journal Article] Toll-like receptor 7(TLR7) SNPs in the 3' untranslated region and intron additively contribute to susceptibility to systemic lupus erythematosus in a Japanese female population2011

    • Author(s)
      Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T andTsuchiya N
    • Journal Title

      Arthritis Res.

      Volume: 13 Pages: 41-41

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of afunctional polymorphism in the 3' untranslated region of SPI1 with systemic lupus erythematosus2011

    • Author(s)
      Hikami K, Kawasaki A, Ito I, Koga M, Ito S, Hayashi T, Matsumoto I, Tsutsumi A, KusaoiM, Takasaki Y, Hashimoto H, Arinami T, Sumida T and Tsuchiya N
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 755-763

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparative suppressive effect in models of autoimmune arthritis by tyrosine kinase inhibitors imatinib and nilotinib2011

    • Author(s)
      Akashi N, Matsumoto I, Tanaka Y, Inoue A, Yamamoto K, Tanaka Y, Umeda N, Hayashi T, Goto D, Ito S, Sekiguchi K and Sumida T
    • Journal Title

      Mod.Rheumatol

      Volume: 21 Pages: 267-275

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparative suppressive effect in models of autoimmune arth ritis by tyrosine kinase inhibitors imatinib and nilotinib.2011

    • Author(s)
      Akashi N
    • Journal Title

      Mod Rheumatol.

      Volume: 11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a functional polymorphism in the 3' untranslated region of SPI1 with systemic lupus erythematosus.2011

    • Author(s)
      Hikami A
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 755-763

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis2010

    • Author(s)
      Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Murata H, Tsutsumi A, Hayashi T, Uchida K, Usui J, Yamagata K and Sumida T
    • Journal Title

      Clin. Exp. Immunol

      Volume: 159 Pages: 1-10

    • Related Report
      2011 Final Research Report
  • [Journal Article] A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models2010

    • Author(s)
      Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M, Li W, Inoue Y, Ackermann K, Shirota H, Matsumoto I, Spyvee M, Schiller S, Sumida T, Gusovsky Fand Lamphier M
    • Journal Title

      Br J. Pharmacol

      Volume: 160 Pages: 292-310

    • Related Report
      2011 Final Research Report
  • [Journal Article] Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population2010

    • Author(s)
      Ito I, Kawasaki A, Ito S, Kondo Y, Sugihara M, Horikoshi M, Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Takasaki Y, Hashimoto H, Matsuta K, Sumida T and Tsuchiya N
    • Journal Title

      Ann Rheum Dis

      Volume: 69 Pages: 936-937

    • Related Report
      2011 Final Research Report
  • [Journal Article] Inhibition of transforming growth factor-b signaling attenuates IL-18 plus IL-2-induced interstitial lung disease in mice2010

    • Author(s)
      Segawa S, Goto D, Yoshiga Y, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S andSumida T
    • Journal Title

      Clin. Exp. Immunol

      Volume: 160 Pages: 394-402

    • Related Report
      2011 Final Research Report
  • [Journal Article] New low-field extremity MRI, compact Tscan : comparison with whole body1.5 tesla conventional MRI2010

    • Author(s)
      Suzuki T, Ito S, Handa S, Kose K, Okamoto Y, Minami M, Sugihara M, Horikoshi M, TsuboiH, Hayashi T, Goto D, Matsumoto I andSumida T
    • Journal Title

      Mod. Rheumatol

      Volume: 20 Pages: 331-336

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population2010

    • Author(s)
      Kawasaki A, Ito I, Ito S, Hayashi T, Goto D, Matsumoto I, Takasaki Y, Hashimoto H, Sumida T and Tsuchiya N
    • Journal Title

      J. Biomed Biotechnol

      Pages: 207578-207578

    • NAID

      120007137993

    • Related Report
      2011 Final Research Report
  • [Journal Article] New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjogren's syndrome2010

    • Author(s)
      Tsuboi H, Matsumoto I, Wakamatsu E, Nakamura Y, Iizuka M, Hayashi T, Goto D, ItoS and Sumida T
    • Journal Title

      Clin. Exp. Immunol

      Volume: 162 Pages: 53-61

    • Related Report
      2011 Final Research Report
  • [Journal Article] Elevated level of serum cystatin-C concentration is a useful predictor for myelosuppression induced by methotrexate for treatment of rheumatoid arthritis2010

    • Author(s)
      Hayashi T, Ito S, Goto D, Matsumoto I andSumida T : Elevated level of serumcystatin-C concentration
    • Journal Title

      Mod. Rheumatol

      Volume: 20 Pages: 548-55

    • NAID

      10027647308

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis2010

    • Author(s)
      Horikoshi M, Suzuki T, Sugihara M, Kondo Y, Tsuboi H, Uehara T, Hama M, Takase K, OhnoS, Ishigatsubo Y, Yoshida Y, Sagawa A, IkedaK, Ota T, Matsumoto I, Ito S and Sumida T
    • Journal Title

      Mod. Rheumatol

      Volume: 20 Pages: 556-560

    • NAID

      10027647341

    • Related Report
      2011 Final Research Report
  • [Journal Article] M3 muscarinic acetylcholine receptor reactive immune response induces Sjogren's syndrome-like sialoadenitis2010

    • Author(s)
      Iizuka M, Wakamatsu E, Tsuboi H, NakamuraY, Hayashi T, Matsui M, Goto D, Ito S, Matsumoto I and Sumida T
    • Journal Title

      J. Autoimmunity

      Volume: 35 Pages: 383-389

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of TNIP1 with systemic lupus erythematosus in a Japanese population : a case-control association study2010

    • Author(s)
      Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham R R, Matsuta K, Behrens T W, Tohma S, Takasaki Y, Hashimoto H, Sumida T andTsuchiya N
    • Journal Title

      Arthritis Res.

      Volume: 12 Pages: 174-174

    • Related Report
      2011 Final Research Report
  • [Journal Article] M3 muscarinic acetylcholine receptor reactive immune response induces Sjogren's syndrome-like sialoadenitis.2010

    • Author(s)
      Iizuka M
    • Journal Title

      J.Autoimmunity

      Volume: 35 Pages: 383-389

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population.2010

    • Author(s)
      Ito I
    • Journal Title

      Ann Rheum Dis. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide.2009

    • Author(s)
      Iwanami K
    • Journal Title

      Arthritis Res Ther. 11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis.2009

    • Author(s)
      Inoue A
    • Journal Title

      Arthritis Res Ther. 11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 関節リウマチにおける抗シトルリン化GPI抗体2012

    • Author(s)
      松本功, 梅田直人, 土屋尚之, 住田孝之
    • Organizer
      第56回日本リウマチ学会総会シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] TIARP欠損による炎症性サイトカイン異常と関節炎発症 @構2012

    • Author(s)
      松本功, 井上明日香, 住田孝之
    • Organizer
      第56回日本リウマチ学会
    • Place of Presentation
      (東京)総会シンポジウム
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunologicalmechanisms in autoimmune arthritis via ubiquitous autoantigens.International Rheumatology symposium2012

    • Author(s)
      Matsumoto I, Sumida T
    • Organizer
      第56回日本リウマチ学会総会
    • Place of Presentation
      シンポジウム
    • Related Report
      2011 Final Research Report
  • [Presentation] Pathophysiology of autoimmune arthritis-From clinic to bench and vice versa-. China-Japan Rheumatology symposium2012

    • Author(s)
      Matsumoto I
    • Organizer
      第56回日本リウマチ学会総会
    • Place of Presentation
      (東京)国際シンポジウ
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-6 receptor inhibitionin autoimmune arthritis. from clinicaland basic point of view-2010

    • Author(s)
      Matsumoto I
    • Organizer
      7^<th> CombinedMeeting of the Orthopaedic ResearchSocieties
    • Place of Presentation
      (CORS)(Kyoto)
    • Year and Date
      2010-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 生物学的製剤導入による外科手術適応例の変動-内科的見地より-2010

    • Author(s)
      松本功
    • Organizer
      第39回リウマチの外科研究会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 関節リウマチにおける自己抗体の病因論2010

    • Author(s)
      松本功
    • Organizer
      第54回日本リウマチ学会総会・学術集会教育セミナー
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自己免疫性関節炎におけるTNFalpha induced adipose related protein(TIARP)の機能解析2010

    • Author(s)
      松本功, 井上明日香, 田中陽子, 住田孝之
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 関節リウマチにおける自己抗体の意義とその産生制御2009

    • Author(s)
      松本功
    • Organizer
      第22回熊本リウマチセミナー
    • Place of Presentation
      熊本全日空ホテル
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Book] 関節リウマチ(RA):診断と治療の進歩病態関節炎モデル2012

    • Author(s)
      松本功
    • Publisher
      日本内科学会雑誌
    • Related Report
      2011 Final Research Report
  • [Book] TGF-b臨床免疫・アレルギー科2012

    • Author(s)
      松本功
    • Publisher
      サイトカ Cンのすべて
    • Related Report
      2011 Final Research Report
  • [Book] 関節リウマチ診療update IL-17阻害は有効か?内科2012

    • Author(s)
      松本功
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] 関節リウマチにおけるTh17細胞と抗IL-17, 23抗体療法2012

    • Author(s)
      松本功
    • Publisher
      最新医学
    • Related Report
      2011 Final Research Report
  • [Book] 膠原病・リウマチ疾患の治療の現状と展望免疫抑制薬・抗リウマチ薬アザチオプリン2011

    • Author(s)
      松本功
    • Publisher
      日本内科学会雑誌
    • Related Report
      2011 Final Research Report
  • [Book] トップランナーに聞く関節リウマチの発症メカニズム解明とその制御機構を追い求めて2011

    • Author(s)
      松本功
    • Publisher
      最新医学
    • Related Report
      2011 Final Research Report
  • [Book] 解糖系酵素に対する自己免疫応答と関節リウマチ2011

    • Author(s)
      松本功, 岩波慶一, 田中陽子, 井上明日香, 田中勇希, 梅田直人, 住田孝之
    • Publisher
      日本臨床免疫学会雑誌
    • Related Report
      2011 Final Research Report
  • [Book] 関節リウマチにおけるTh17細胞の意義2011

    • Author(s)
      松本功
    • Publisher
      リウマチ科
    • Related Report
      2011 Final Research Report
  • [Book] 生物学的製剤の副作用:Cochraneデーターベースより2011

    • Author(s)
      松本功
    • Publisher
      RAtrends
    • Related Report
      2011 Final Research Report
  • [Book] medicina2011

    • Author(s)
      松本功
    • Publisher
      関節リウマチを疑ったら診断治療のupdateと鑑別すべき膠原病-シェーグレン症候群-
    • Related Report
      2011 Final Research Report
  • [Book] K/BxNマウス-血清移入関節炎-2011

    • Author(s)
      松本功
    • Publisher
      Clinical Calcium
    • Related Report
      2011 Final Research Report
  • [Book] TIARPによる炎症性サイトカインの産生抑制2011

    • Author(s)
      井上明日香, 松本功, 住田孝之
    • Total Pages
      55
    • Publisher
      臨床免疫・アレルギー科
    • Related Report
      2011 Final Research Report
  • [Book] 関節リウマチにおける自己抗体の病態への関与2011

    • Author(s)
      松本功
    • Publisher
      リウマチ科
    • Related Report
      2011 Final Research Report
  • [Book] シェーグレン症候群内科2011

    • Author(s)
      松本功
    • Publisher
      薫風吹く膠原病診療-臨床を駆ける進歩の風-
    • Related Report
      2011 Final Research Report
  • [Book] 再発性多発軟骨炎GUIDELINE膠原病・リウマチ改訂第2版、小池隆夫、住田孝之編集2010

    • Author(s)
      松本功
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] 多発性筋炎/皮膚筋炎COLORATLAS膠原病・リウマチ改訂第2版住田孝之編集2010

    • Author(s)
      松本功
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] 免疫グロブリン・補体・免疫複合体リウマチ・膠原病内科クリニカルスタンダード2010

    • Author(s)
      松本功
    • Publisher
      文光堂
    • Related Report
      2011 Final Research Report
  • [Book] 自己免疫関節炎における2010

    • Author(s)
      井上明日香, 松本功, 住田孝之
    • Publisher
      TNFa-inducedadipose related protein(TIARP)の役割医学のあゆみ
    • Related Report
      2011 Final Research Report
  • [Book] シェーグレン症候群の病態形成におけるM3ムスカリン作動性アセチルコリン受容体に対する自己免疫応答の解明2010

    • Author(s)
      飯塚麻菜, 若松英, 松本功, 坪井洋人, 中村友美, 松井稔, 住田孝之
    • Publisher
      日本臨床免疫学会雑誌
    • Related Report
      2011 Final Research Report
  • [Book] リウマチ科2010

    • Author(s)
      松本功
    • Publisher
      実験的関節炎に対するリボゾームを用いた抗原特異的治療戦略
    • Related Report
      2011 Final Research Report
  • [Book] 膠原病-病態への新たなアプローチと治療展開-関節リウマチの分子標的と制御2010

    • Author(s)
      松本功
    • Publisher
      最新医学
    • Related Report
      2011 Final Research Report
  • [Book] M3R反応性T細胞とシェーグレン症候群2010

    • Author(s)
      住田孝之, 坪井洋人, 飯塚麻菜, 中村友美, 松本功
    • Publisher
      Mebio
    • Related Report
      2011 Final Research Report
  • [Book] TNF・誘導分子TIARPと自己免疫疾患2010

    • Author(s)
      松本功, 井上明日香, 田中陽子, 明石直嗣, 岩波慶一, 住田孝之
    • Publisher
      Mebio
    • Related Report
      2011 Final Research Report
  • [Book] RA の治療標的としてのimmunoproteasomeFrontiers in Rheumatology & Clinical2010

    • Author(s)
      明石直嗣, 松本功, 住田孝之
    • Publisher
      Immunology
    • Related Report
      2011 Final Research Report
  • [Book] 日本臨床免疫学会雑誌2010

    • Author(s)
      坪井洋人, 松尾直美, 飯塚麻菜, 中村友美, 松本功, 住田孝之
    • Publisher
      シェーグレン症候群におけるM3ムスカリン作動性アセチルコリン受容体抗体のエピトープと機能解析
    • Related Report
      2011 Final Research Report
  • [Book] 関節炎における2010

    • Author(s)
      松本功, 井上 セ日香, 田中陽子
    • Publisher
      TNF a-induced adiposerelated protein (TIARP)リウマチ科
    • Related Report
      2011 Final Research Report
  • [Book] 関節リウマチ治療におけるイマチニブの可能性2010

    • Author(s)
      明石直嗣, 松本功, 住田孝之
    • Publisher
      分子リウマチ治療
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/rheumatology/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/rheumatology

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/rheumatology

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/rheumatology

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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