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Search for genetic polymorphisms associated with RA severity and the response to treatment.

Research Project

Project/Area Number 21591264
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKyoto University

Principal Investigator

OHMURA Koichiro  京都大学, 医学研究科, 講師 (40432372)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords関節リウマチ / SNP / 疾患関連遺伝子 / 治療反応性 / 全ゲノム関連解析 / HLA / CCP / ACPA / GWAS / 関連解析 / 重症化
Research Abstract

We collected 420 DNA samples and clinical information from multiple institutes which has many rheumatoid arthritis(RA) patients under treatment with tocilizumab. Now we are ready to start genome-wide association study on finding the polymorphisms which are related to the response to tocilizumab treatment.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2012 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 15 results) Presentation (7 results)

  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese2012

    • Author(s)
      Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Ohmura K, et al.
    • Journal Title

      PLoS Genet

      Volume: 8(1)

    • NAID

      120005906866

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis : no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1* 09 : 012012

    • Author(s)
      Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, et al.
    • Journal Title

      Ann Rheum Dis

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis : no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1*09:012012

    • Author(s)
      Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, Saji H, Taniguchi A, Momohara S, Yamanaka H, Matsuda F, Mimori T
    • Journal Title

      Ann Rheum Dis

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A arge-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects2011

    • Author(s)
      Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, et Al.
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 2134-2139

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis-a genome-wide study combined with immunological analyses2011

    • Author(s)
      Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, et al.
    • Journal Title

      PLoS ONE.

      Volume: 6

    • NAID

      120003184064

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk actor in Japanese and European populations2011

    • Author(s)
      Meziani R, Yamada R, Takahashi M, Ohigashi K, Morinobu A, Ohmura K, et al.
    • Journal Title

      Mod Rheumatol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population2011

    • Author(s)
      Terao C, Yamada R, Ohmura K, Takahashi M, Kawaguchi T, Kochi Y, et al.
    • Journal Title

      Hum Mol Genet

      Volume: 20 Pages: 2680-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population2011

    • Author(s)
      Terao C, Yamada R, Ohmura K, Takahashi M, Kawaguchi T, Kochi Y; Human Disease Genomics Working Group; RA Clinical and Genetic Study Consortium, Okada Y, Nakamura Y, Yamamoto K, Melchers I, Lathrop M, Mimori T, Matsuda F
    • Journal Title

      Hum Mol Genet

      Volume: 20 Pages: 2680-2685

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses2011

    • Author(s)
      Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, Toda Y, Yamamoto N; Human Disease Genomics Working Group; Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium, Shinkura R, Shimizu M, Gut I, Heath S, Melchers I, Manabe T, Lathrop M, Mimori T, Yamada R, Matsuda F
    • Journal Title

      PLoS One

      Volume: 6

    • NAID

      120003184064

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects2011

    • Author(s)
      Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, Shimada K, Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 2134-2139

    • NAID

      120003796492

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-citrullinated peptide antibody negative RA is a genetically distinct subset : a definitive study using only bone-erosive ACPA-negativerheumatoid arthritis2010

    • Author(s)
      K. Ohmura, C. Terao, E. Maruya, M. Katayama, K. Matoba, K. Shimada, et al.
    • Journal Title

      Rheumatology(Oxford)

      Volume: 49 Pages: 2298-304

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility2010

    • Author(s)
      Y. Kochi, Y. Okada, A. Suzuki, K. Ikari, C. Terao, A., K. Ohmura, et al.
    • Journal Title

      Nat Genet

      Volume: 42(6) Pages: 515-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-citrullinated peptide antibody-negative RA is a genetical-ly distinct subset : a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.2010

    • Author(s)
      Koichiro Ohmura
    • Journal Title

      Rheumatology (Oxford)

      Volume: 49 Pages: 2298-2304

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility2010

    • Author(s)
      Yuta Kochi
    • Journal Title

      Nat Genet

      Volume: 42 Pages: 515-519

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RAの関節病変重症化にかかわる遺伝的要因2010

    • Author(s)
      大村浩一郎
    • Journal Title

      リウマチ科

      Volume: 43 Pages: 142-149

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 早期診断における血清検査-特に抗CCP抗体の有用性-2010

    • Author(s)
      大村浩一郎
    • Journal Title

      Medical Practice

      Volume: 27 Pages: 2025-2028

    • Related Report
      2010 Annual Research Report
  • [Journal Article] RAの関節病変重症化にかかわる遺伝的要因2010

    • Author(s)
      大村浩一郎
    • Journal Title

      リウマチ科 43

      Pages: 142-149

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Aberrant splicing of the milk fat globule-EGF factor 8 (MFGE8) gene in human systemic lupus erythematosus.2010

    • Author(s)
      H.Yamaguchi,
    • Journal Title

      Eur J Immunol. 40

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 抗シトルリン化ペプチド抗体陰性関節リウマチは遺伝的背景の異なるサブセットである?2009

    • Author(s)
      大村浩一郎
    • Journal Title

      日本臨床免疫学会会誌 32

      Pages: 484-491

    • NAID

      10026352391

    • Related Report
      2009 Annual Research Report
  • [Presentation] A HAPLOTYPE OF THE HUMAN AIRE GENE IS ASSOCIATED WITH THE RISK FOR RHEUMATOID ARTHRITIS IN JAPANESE POPULATION2011

    • Author(s)
      C. Terao, K. Ohmura, et al.
    • Organizer
      European League Against Rheumatism
    • Place of Presentation
      London
    • Year and Date
      2011-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] A HAPLOTYPE OF THE HUMAN AIRE GENE IS ASSOCIATED WITH THE RISK FOR RHEUMATOID ARTHRITIS IN JAPANESE POPULATION2011

    • Author(s)
      C.Terao, K.Ohmura, R.Yamada, Y.Kochi, Y.Okada, Y.Nakamura, K.Yamamoto, I.Melchers, M.Lathrop, T.Mimori, F.Matsuda
    • Organizer
      European League Against Rheumatism 2011
    • Place of Presentation
      Londonイギリス
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] HLA-DR8 is associated with ACPA-negative RA in Japanese2010

    • Author(s)
      K. Ohmura, C. Terao, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-22
    • Related Report
      2011 Final Research Report
  • [Presentation] LA-DR8 is associated with ACPA-negative RA in Japanese2010

    • Author(s)
      Koichiro Ohmura
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗CCP抗体陰性関節リウマチとHLA-DRB1 Shared epitopeとの関連2009

    • Author(s)
      片山昌紀
    • Organizer
      第5回テーラーメイド医療を目指したゲノム情報活用基盤技術
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2009-08-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Two cases of adult TRAPS(tumor necrosis factor receptor-associated periodic syndrome) treated with etanercept2009

    • Author(s)
      Kanako Takano, Koichiro Ohmura, et al.
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-07-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts2009

    • Author(s)
      C.Terao
    • Organizer
      ヨーロッパリウマチ学会
    • Place of Presentation
      Bella Center (コペハーゲン)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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