c-Cbl-interacting protein of 85 kDa(CIN85) regulates the function of autoreactive B cells
Project/Area Number |
21591267
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 医学研究院, 教授 (80380385)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 自己免疫疾患 / 細胞・組織 / 免疫学 / シグナル伝達 / 内科 |
Research Abstract |
In the present study, we have shown a novel effect of CIN85 on the differentiation of human B cells, and have also established Bcellspecific C1N85 knockdown mice that can serve to evaluate an in vivo function of this adaptor molecule.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Selfrenewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia2011
Author(s)
Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mort Y, lino T, Yamauchi T, Eta T, Niiro H, Iwasaki H, Takenaka K, and Akashi K
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Journal Title
Cancer Cell
Volume: 20(2)
Issue: 2
Pages: 246-259
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of immune re constitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant re constitution of Thl CD4+ T cells2011
Author(s)
Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, and Akashi K
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Journal Title
Rheumatology
Volume: 50(5)
Pages: 944-52
Related Report
Peer Reviewed
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[Journal Article] Tacrolimus is effective for lupus nephritis patients with persistent proteinuria2010
Author(s)
Uchino A, Tsukamoto H, Nakashima H, Yoshizawa S, Furugo I, Mitoma H, Oryoji K, Shimoda T, Niiro H, Tada Y, Yano T, Nonaka T, Oishi R, Akashi K, and Horiuchi T
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Journal Title
Crin Exp Rheumatol
Volume: 28(1)
Pages: 6-12
URL
Related Report
Peer Reviewed
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[Journal Article] FLTs-ITD upregulates MCL-l to promote survival of stem cells in acute myeloid leukemia via FLTs-ITD specific STATs activation Blood2009
Author(s)
Yoshimoto G, Miyamoto T, Jabbarzadeh Tabrizi S, lino T, Rocnik IL, Kikushige Y, Mort Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno S-I, Niiro H, Gilliland GD, and Akashi K
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Journal Title
Blood
Volume: 114(24)
Issue: 24
Pages: 5034-5043
DOI
ISSN
0006-4971, 1528-0020
Related Report
Peer Reviewed
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[Journal Article] T cell leukemia/lymphoma 1 and Galectin-l regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins2009
Author(s)
JabbarzadehTabrizi S, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, Wakasaki T, Baba E, Shimoda S, Miyamoto T, Hara T, Akashi K
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Journal Title
J. Immunol
Volume: 182(3)
Pages: 1490-1499
URL
Related Report
Peer Reviewed
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[Journal Article] Identification of the human eosinophil lineagecommitted progenitor : revision of phenotypic definition of the human common myeloid progenitor2009
Author(s)
Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, Okeda A, Uike N, Niiro H, Takenaka K, Nagafuji K, Miyamoto T, Harada M, Takatsu K, Akashi K
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Journal Title
J. Exp. Med
Volume: 206(1)
Issue: 1
Pages: 183-193
DOI
Related Report
Peer Reviewed
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