c-Cbl-interacting protein of 85 kDa(CIN85) regulates the function of autoreactive B cells

• Project/Area Number: 21591267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kyushu University
• Principal Investigator: NIIRO Hiroaki 九州大学, 大学病院, 助教 (20380636)
• Co-Investigator(Kenkyū-buntansha): AKASHI Koichi 九州大学, 医学研究院, 教授 (80380385)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 自己免疫疾患 / 細胞・組織 / 免疫学 / シグナル伝達 / 内科

Research Abstract

In the present study, we have shown a novel effect of CIN85 on the differentiation of human B cells, and have also established Bcellspecific C1N85 knockdown mice that can serve to evaluate an in vivo function of this adaptor molecule.

Research Products

• [Journal Article] Selfrenewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia (2011)
  • Author(s): Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mort Y, lino T, Yamauchi T, Eta T, Niiro H, Iwasaki H, Takenaka K, and Akashi K
  • Journal Title: Cancer Cell Volume: 20(2) Issue: 2 Pages: 246-259
  • DOI: 10.1016/j.ccr.2011.06.029
  • Peer Reviewed
• [Journal Article] Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis (2011)
  • Author(s): Shimoda S.
  • Journal Title: Hepatology Volume: 53(4) Issue: 4 Pages: 1270-1281
  • DOI: 10.1002/hep.24194
  • Peer Reviewed
• [Journal Article] Analysis of immune re constitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant re constitution of Thl CD4+ T cells (2011)
  • Author(s): Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, and Akashi K
  • Journal Title: Rheumatology Volume: 50(5) Pages: 944-52
  • Peer Reviewed
• [Journal Article] Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia (2011)
  • Author(s): Kikushige Y, et al
  • Journal Title: Cancer Cell Volume: 20 Pages: 246-259
  • Peer Reviewed
• [Journal Article] Analysis of immune reconstitution after autologous CD34^+ stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4^+ T cells (2011)
  • Author(s): Tsukamoto H, et al
  • Journal Title: Rheumatology Volume: 50 Issue: 5 Pages: 944-952
  • DOI: 10.1093/rheumatology/keq414
  • Peer Reviewed
• [Journal Article] A critical role of c-Cbl interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas via the Ras-ERK pathway (2010)
  • Author(s): Wakasaki T, Masuda M, Niiro H, Jabbarzadeh-Tabrizi S, Neda K, Taniyama T, Komune S, and Akashi K
  • Journal Title: Neoplasia Volume: 12(10) Pages: 789-796
  • URL: http://www.neoplasia.com8pdf/manuscript/v12i10/neo10396.pdf
  • Peer Reviewed
• [Journal Article] Tacrolimus is effective for lupus nephritis patients with persistent proteinuria (2010)
  • Author(s): Uchino A, Tsukamoto H, Nakashima H, Yoshizawa S, Furugo I, Mitoma H, Oryoji K, Shimoda T, Niiro H, Tada Y, Yano T, Nonaka T, Oishi R, Akashi K, and Horiuchi T
  • Journal Title: Crin Exp Rheumatol Volume: 28(1) Pages: 6-12
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20346231
  • Peer Reviewed
• [Journal Article] SLEにおけるinterferon signature:発見から臨床試験までの道のり (2010)
  • Author(s): 新納宏昭, ほか
  • Journal Title: リウマチ科 Volume: 43 Pages: 427-433
• [Journal Article] Tacrolimus is effective for lupus nephritis patients with persistent proteinuria. (2010)
  • Author(s): Uchino A, et al.
  • Journal Title: Clin.Exp.Rheumatol. Volume: 28 Pages: 6-12
  • Peer Reviewed
• [Journal Article] A critical role of c-Cbl interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas via the Ras-ERK pathway. (2010)
  • Author(s): Wakasaki T, et al.
  • Journal Title: Neoplasia Volume: 12 Pages: 789-796
  • Peer Reviewed
• [Journal Article] FLTs-ITD upregulates MCL-l to promote survival of stem cells in acute myeloid leukemia via FLTs-ITD specific STATs activation Blood (2009)
  • Author(s): Yoshimoto G, Miyamoto T, Jabbarzadeh Tabrizi S, lino T, Rocnik IL, Kikushige Y, Mort Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno S-I, Niiro H, Gilliland GD, and Akashi K
  • Journal Title: Blood Volume: 114(24) Issue: 24 Pages: 5034-5043
  • DOI: 10.1182/blood-2008-12-196055
  • ISSN: 0006-4971, 1528-0020
  • Peer Reviewed
• [Journal Article] T cell leukemia/lymphoma 1 and Galectin-l regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins (2009)
  • Author(s): JabbarzadehTabrizi S, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, Wakasaki T, Baba E, Shimoda S, Miyamoto T, Hara T, Akashi K
  • Journal Title: J. Immunol Volume: 182(3) Pages: 1490-1499
  • URL: http://www.jimmunol.org/content/182/3/1490.long
  • Peer Reviewed
• [Journal Article] Identification of the human eosinophil lineagecommitted progenitor : revision of phenotypic definition of the human common myeloid progenitor (2009)
  • Author(s): Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, Okeda A, Uike N, Niiro H, Takenaka K, Nagafuji K, Miyamoto T, Harada M, Takatsu K, Akashi K
  • Journal Title: J. Exp. Med Volume: 206(1) Issue: 1 Pages: 183-193
  • DOI: 10.1084/jem.20081756
  • Peer Reviewed
• [Journal Article] Identification of the human eosinophil lineage-committed progenitor : revision of phenotypic definition of the human common myeloid progenitor (2009)
  • Author(s): Mori Y, et al.
  • Journal Title: J.Exp.Med. 206 Pages: 183-193
  • Peer Reviewed
• [Journal Article] T cell leukemia/lymphoma 1 and Galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins (2009)
  • Author(s): Jabbarzadeh-Tabrizi S, et al.
  • Journal Title: J.Immunol. 182 Pages: 1490-1499
  • Peer Reviewed
• [Journal Article] FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation (2009)
  • Author(s): Yoshimoto G, et al.
  • Journal Title: Blood 114 Pages: 5034-5043
  • Peer Reviewed
• [Presentation] 健常人ならびにSLE患者B細胞におけるIRAK発現とその役割新納宏昭、ジャバルザデタブリジシアマック (2011)
  • Author(s): 大田俊一郎、野田久美子、上田尚靖、田中淳、藤健太郎、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
  • Organizer: 第55回日本リウマチ学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-19
• [Presentation] 健常人ならびにSLE患者B細胞におけるIRAK発現とその役割 (2011)
  • Author(s): 新納宏昭, 他
  • Organizer: 第55回日本リウマチ学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-19
• [Presentation] ヒトB細胞におけるIRAK発現調節と自己免疫疾患におけるその関与 (2010)
  • Author(s): 新納宏昭、JabbarzadehTabrizi Siamak,相澤久美子、上田尚靖、押領司健介、三苫弘喜、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
  • Organizer: 第54回日本リウマチ学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-04-23
• [Presentation] A vital role of CIN85 in Cbl-mediated regulation of B cell survival, growth and differentiation. (2010)
  • Author(s): Niiro H, et al.
  • Organizer: 2010 Keystone Symposia
  • Place of Presentation: Taos Convention Center, Taos, New Mexico, USA
  • Year and Date: 2010-02-24
• [Presentation] A vital role of CIN85 in Cblmediated regulation of B cell survival, growth and differentiation (2010)
  • Author(s): Hiroaki Niiro, Siamak JabbarzadehTabrizi, Kumiko Noda, Yasushi Inoue, Yojiro Arinobu, Koichi Akashi
  • Organizer: 2010 Keystone Symposia February
  • Place of Presentation: Taos Convention Center, Taos, New Mexico, USA
• [Presentation] Cb1のB細胞機能制御におけるCIN85の役割/A vital role of CIN85 in Cblmediated regulation of B cell functions (2009)
  • Author(s): Hiroaki Niiro, Siamak JabbarzadehTabrizi, Kumiko Noda, Yasushi Inoue, Yojiro Arinobu, Shinji Shimoda, Eishi Baba, Tadayoshi Taniyama, Toshiro Hara, Koichi Akashi
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Critical role of CIN85 in Cblmediated regulation of B cell function after antigen receptor stimulation (2009)
  • Author(s): Hiroaki Niiro, Siamak JabbarzadehTabrizi, Kumiko Aizawa, Yasushi Inoue, Yojiro Arinobu, Koichi Akashi
  • Organizer: 96th annual meeting AAI Immunology
  • Place of Presentation: Washington State Convention & Trade Center, Seattle, WA
  • Year and Date: 2009-05-10
• [Presentation] Critical role of CIN85 in Cbl-mediated regulation of B cell function after antigen receptor stimulation (2009)
  • Author(s): Niiro H, et al.
  • Organizer: 96^<th> annual meeting AAI Immunology 2009
  • Place of Presentation: Washington State Convention & Trade Center
  • Year and Date: 2009-05-10
• [Presentation] 抗原受容体シグナルによる正常ならびにSLE B細胞サブセットの生存の制御 (2009)
  • Author(s): 新納宏昭、ジャバルザデタブリジシアマック、相澤久美子、三苫弘喜、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
  • Organizer: 第53回日本リウマチ学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/intmedl/immune/