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Association of linkage between autoantigens and, ubiquitin. proteasome system in autoantibody production

Research Project

Project/Area Number 21591271
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionJuntendo University

Principal Investigator

TAKASAKI Yoshinari  順天堂大学, 医学部, 教授 (80154772)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsautoantigen / proteasome / ubiquitin / autoantibody / autoanitibody / ubiqutin / 自己免疫
Research Abstract

We studied immune response to components of proteasome using sera from patients with various connective tissue diseases by immunoblotting. Then, we found that there is a linkage of autoimmune response among components of proteasome and their binding proteins. In addition, We found that circulating proteasome detected by sandwich type ELISA is significantly associated with autoimmune response to proteasome and its binding proteins. These results suggested that the circulating ubiquitin-proteasome complex binding with autoantigens in association with its biologic function is playing an important role to induce autoimmune response to its binding antigens.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (7 results) Book (5 results)

  • [Journal Article] Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus2011

    • Author(s)
      Nakano S, Morimoto S, Suzuki S, Watanabe T, Amano H, Takasaki Y
    • Journal Title

      Rheumatology

      Volume: 49 Pages: 876-881

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated serum level of circulating syndecan-1(CD138) in active systemic lupus erythematosus2011

    • Author(s)
      Minowa K, Amano H, Nakano S, Ando S, Watanabe T, Nakiri Y, Amano E, Tokano Y, Morimoto S, Takasaki Y
    • Journal Title

      Autoimmunity

      Volume: 44 Pages: 357-362

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011

    • Author(s)
      Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Akiba H, Takasaki Y
    • Journal Title

      Arthritis Res

      Volume: Ther13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Ro/SSA Antibodies Are an Independent Factor Associated with an Insufficient Response to Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis2011

    • Author(s)
      Matsudaira R, Tamura N, Sekiya F, Ogasawara M, Yamanaka K, Takasaki Y
    • Journal Title

      J Rheumatol

      Volume: 38 Pages: 2346-2354

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated serum level of circulating syndeecn-1 (CD138) in active systemic lupus erythematosus2011

    • Author(s)
      Minowa K
    • Journal Title

      Autoimmunity

      Volume: 44 Pages: 357-362

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011

    • Author(s)
      Kawamoto T
    • Journal Title

      Arthritis Res Ther

      Volume: 13

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Ro/SSA Antibodies Are an Independent Factor Associated with an Insufficient Response to Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis2011

    • Author(s)
      Matsudaira R
    • Journal Title

      J Rheumatol

      Volume: 28 Pages: 2346-2354

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis2011

    • Author(s)
      Kida I
    • Journal Title

      Mod Rheumatol

      Volume: 21 Pages: 43-50

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women : a case-control association study2011

    • Author(s)
      Kawasakil A
    • Journal Title

      Arthritis Res Ther

      Volume: 13

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a Functional Polymorphism in the 3'-Untranslated Region of SPI1 With Systemic Lupus Erythematosus2011

    • Author(s)
      Hikami K
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 755-763

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis2011

    • Author(s)
      Ogasawara M
    • Journal Title

      Clin Rheumatol

      Volume: 31 Pages: 251-257

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice2010

    • Author(s)
      Toyama S, Tamura N, Haruta K, Karakida T, Mori S, Watanabe T, Yamori T, Takasaki Y
    • Journal Title

      Arthritis Res Ther

      Volume: 12 Pages: 1-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.2010

    • Author(s)
      Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 94 Pages: 804-810

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice.2010

    • Author(s)
      Toyama S, Tamura N, Haruta K, Karakida T, Mori S, Watanabe T, Yamori T, Takasaki Y
    • Journal Title

      Arthritis Res Ther

      Volume: 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus.2010

    • Author(s)
      Nakano S, Morimoto S, Suzuki S, Watanabe T, Amano H, Takasaki Y
    • Journal Title

      Rheumatology

      Volume: 69 Pages: 936-937

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome2009

    • Author(s)
      Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK
    • Journal Title

      Front Biosci

      Volume: 14 Pages: 3733-3739

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-proteasome activator 28 α is a novel anti-cytoplasmic antibody in patients with systemic lupus erythematosus and Sjogren's syndrome2009

    • Author(s)
      Matsushita M, Matsudaira R, Ikeda K, Nawata M, Tamura N, Takasaki Y
    • Journal Title

      Mod Rheumatol

      Volume: 19 Pages: 622-628

    • NAID

      10027167756

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis2009

    • Author(s)
      Nozawa K, Fritzler MJ, Takasaki Y, Wood MR, Chan EKL
    • Journal Title

      Cell Biol Int 33

      Pages: 48-157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-proteasome activator 28α is a novel anti-cytoplasmic antibody in patients with systemic lupus erythematosus and Sjogren's syndrome2009

    • Author(s)
      Matsushita M, Matsudaira R, Ikeda K, Nawata M, Tamura N, Takasaki Y
    • Journal Title

      Mod Rheumatol 19

      Pages: 622-628

    • NAID

      10027167756

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoattractant mechanism of Th1 cells in class III and IV lupus nephritis2009

    • Author(s)
      Morimoto S, Tokano Y, Nakano S, Watanabe T, Tamayama Y, Mitsuo A Suzuki J, Kaneko H, Sekigawa I, Takasaki Y
    • Journal Title

      Autoimmunity 42

      Pages: 143-149

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] REGENERATING GENE(REG) 1 ALPHA PROMOTES PROGRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS2011

    • Author(s)
      Nozawa K, Fujishiro M, Takasaki Y, Sekigawa
    • Organizer
      ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2011
    • Place of Presentation
      London, British
    • Year and Date
      2011-07-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 関節リウマチの予後判定に必要な検査とその評価法2011

    • Author(s)
      高崎芳成
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸,ポートピアホテル
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膠原病鑑別診断のポイント2010

    • Author(s)
      高崎芳成
    • Organizer
      第25回日本臨床リウマチ学会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Role for TIM-2 in Collagen-Induced Arthritis2010

    • Author(s)
      Kawamoto T, Akiba H, Abe Y, Morimoto S, Yamaji K, Tamura N, Takasaki Y
    • Organizer
      74th Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Anti-Ro/SS-A antibody is an independent factor of insufficient response to anti-TNF-alpha monoclonal antibodies in patients with rheumatoid arthritis2010

    • Author(s)
      Matsudaira R, Tamura N, Sekiya F, Watanabe T, Ogasawara M, Takasaki Y
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      Rome
    • Year and Date
      2010-06-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Autoantibodies in Connective Tissue Diseases-Its Mechanism of Production and Clinical Significance2009

    • Author(s)
      Takasaki Y
    • Organizer
      Asia Pacific League of Associations for Rheumatology with the Philippine Rheumatology Association
    • Place of Presentation
      Manila, Philippine
    • Year and Date
      2009-11-27
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Prevalence and Clinical Significance of the Anti-p53 Antibody in Systemic Lupus Erythematosus2009

    • Author(s)
      Yamanaka K, Nakano S, Kanai Y, Asano M, Ikeda K, Thoyama S, Ishiyama K, Takasaki Y
    • Organizer
      73th Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2009-10-19
    • Related Report
      2011 Final Research Report
  • [Book] Wegener肉芽腫症(多発血管炎性肉芽腫症:GPA).膠原病の肺合併症診療マニュアル2011

    • Author(s)
      高崎芳成
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Annual Research Report
  • [Book] エタネルセプト/エンブレル.関節リウマチ生物学的製剤の正しい使い方とは?2011

    • Author(s)
      高崎芳成
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Annual Research Report
  • [Book] MCTDの病態別治療指針・腎障害.混合性結合組織病の診療ガイドライン2011

    • Author(s)
      高崎芳成
    • Publisher
      厚生労働科学研究費難病治療克服事業混合性結合組織病の病態解明と治療法の確立に関する研究班
    • Related Report
      2011 Annual Research Report
  • [Book] 全身性エリテマトーデス,リウマチ・膠原病内科クリニカルスタンダード2010

    • Author(s)
      高崎芳成
    • Total Pages
      9
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report
  • [Book] 膠原病2009

    • Author(s)
      高崎芳成
    • Total Pages
      191
    • Publisher
      誠文堂新光社
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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