Association of linkage between autoantigens and, ubiquitin. proteasome system in autoantibody production
| Project/Area Number |
21591271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | autoantigen / proteasome / ubiquitin / autoantibody / autoanitibody / ubiqutin / 自己免疫 |
|---|
| Research Abstract |
We studied immune response to components of proteasome using sera from patients with various connective tissue diseases by immunoblotting. Then, we found that there is a linkage of autoimmune response among components of proteasome and their binding proteins. In addition, We found that circulating proteasome detected by sandwich type ELISA is significantly associated with autoimmune response to proteasome and its binding proteins. These results suggested that the circulating ubiquitin-proteasome complex binding with autoantigens in association with its biologic function is playing an important role to induce autoimmune response to its binding antigens.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011
Author(s)
Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Akiba H, Takasaki Y
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Journal Title
Arthritis Res
Volume: Ther13
Related Report
Peer Reviewed
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[Journal Article] FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.2010
Author(s)
Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y
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Journal Title
Biochem Biophys Res Commun
Volume: 94
Pages: 804-810
Related Report
Peer Reviewed
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[Journal Article] Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome2009
Author(s)
Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK
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Journal Title
Front Biosci
Volume: 14
Pages: 3733-3739
Related Report
Peer Reviewed
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[Book] 膠原病2009
Author(s)
高崎芳成
Total Pages
191
Publisher
誠文堂新光社
Related Report
