Investigation of the mechanism of cardiovascular damage in a rat model of arthritis
| Project/Area Number |
21591274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Minoru 川崎医科大学, 医学部, 講師 (70449891)
YADA Toyotaka 川崎医科大学, 医学部, 講師 (00210279)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Katsuhiko 川崎医科大学, 医学部, 教授 (10263245)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 関節リウマチ / アジュバント関節炎 / 関節炎モデル / アンジオテンシン / 内皮機能 / 活性酸素 / 炎症 / 血管障害 / 心肥大 / うっ血性心不全 / 酸化ストレス / NAD(P)H oxidase / サイトカイン / IL-6 / TNFα / 血圧 |
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| Research Abstract |
The risks of cardiovascular disease and death are higher among patients with rheumatoid arthritis(RA) than the general population. Previous studies identified the presence of endothelial dysfunction in RA patients and rat adjuvant-induced arthritis. This study demonstrated that locally activated renin-angiotensin system(RAS) is involved in the increased vascular oxidative stress and endothelial dysfunction in the arthritis model. Our findings provide a scientific rationale for a trial of RAS inhibitors to reduce cardiovascular mortality in patients with RA.
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Report
(4 results)
Research Products
(10 results)
