| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
This study was aimed to investigate the mechanism of action of biologic agents by using mouse models of autoimmune diseases. The analysis of the inflammatory bowel disease model revealed that both anti-TNF antibody and anti-IL-6 receptor antibody can restrain expansion of colitogenic helper T cells, thereby exhibiting potent inhibitory effect on colitis. Anti-IL-6R antibody also could regulate the balance between Th17 cells and Treg cells. In contrast, another agent TNFR-Fc exhibited no suppressive effect on colitis. This study thus characterized the difference in the mechanism between biologic agents. Further studies on the new agent(abatacept) and on the new mouse model of microscopic polyangiitis are currently in progress.
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