| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Crk-associated substrate lymphocyte type(Cas-L) is an integrin signaling adaptor protein composed of multiple domains serving as a substrate for a variety of tyrosine kinases. Cas-L functions in diverse biological processes such as cell attachment, migration and invasion, apoptosis, and cell cycle progression. To elucidate the function of Cas-L in autoimmune diseases and host defence, we employed Cas-L knockout mice. It was shown that these mice relatively resistant to collagen-induced arthritis, on the other hands, they were susceptible to Citrobacter rodentium infection of colon.
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