Analysis of collagen-induced arthritis and bacterial colitis using Cas-L null mice
Project/Area Number |
21591278
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | The University of Tokyo |
Principal Investigator |
IWATA Satoshi 東京大学, 医科学研究所, 特任講師 (00396871)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | インテグリン / シトロバクター / 病原性大腸菌 / コラーゲン関節炎 / Nedd9 / HEF-1 / 接着分子 / コラーゲン誘発関節炎 / 感染性大腸炎 / Cas / 関節リウマチ / 骨粗鬆症 / 免疫学 |
Research Abstract |
Crk-associated substrate lymphocyte type(Cas-L) is an integrin signaling adaptor protein composed of multiple domains serving as a substrate for a variety of tyrosine kinases. Cas-L functions in diverse biological processes such as cell attachment, migration and invasion, apoptosis, and cell cycle progression. To elucidate the function of Cas-L in autoimmune diseases and host defence, we employed Cas-L knockout mice. It was shown that these mice relatively resistant to collagen-induced arthritis, on the other hands, they were susceptible to Citrobacter rodentium infection of colon.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Characterization of cancer stem cell properties of CD24 and CD26-positive human malignant mesothelioma cells2012
Author(s)
Yamazaki, H., Naito, M., Ghani, F. I., Dang, N. H., Iwata, S., and Morimoto, C.
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Journal Title
Biochem Biophys Res Commun
Volume: 419
Pages: 529-536
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[Journal Article] Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia2011
Author(s)
Yamazaki, H., Xu, C. W., Naito, M., Nishida, H., Okamoto, T., Ghani, F. I., Iwata, S., Inukai, T., Sugita, K., and Morimoto, C.
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Journal Title
Biochem Biophys Res Commun
Volume: 409
Pages: 14-21
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[Journal Article] Identification of cancer stem cell markers in human malignant mesothelioma cells2011
Author(s)
Ghani, F. I., Yamazaki, H., Iwata, S., Okamoto, T., Aoe, K., Okabe, K., Mimura, Y., Fujimoto, N., Kishimoto, T., Yamada, T., et al.
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Journal Title
Biochem Biophys Res Commun
Volume: 404
Pages: 735-742
Related Report
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[Journal Article] Identification of cancer stem cell markers in human malignant mesothelioma cells.2011
Author(s)
Ghani FI, Yamazaki H, Iwata S, Okamoto T, Aoe K, Okabe K, Mimura Y, Fujimoto N, Kishimoto T, Yamada T, Xu CW, Morimoto C
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Journal Title
Biochem Biophys Res Commun
Volume: 404(2)
Pages: 735-42
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Peer Reviewed
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[Journal Article] Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects2010
Author(s)
Otsuki, N., Dang, N. H., Kumagai, E., Kondo, A., Iwata, S., and Morimoto, C.
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Journal Title
Journal of ethnopharmacology
Volume: 127
Pages: 760-767
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[Journal Article] Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation2010
Author(s)
Arimoto-Miyamoto, K., Kadowaki, N., Kitawaki, T., Iwata, S., Morimoto, C., and Uchiyama, T.
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Journal Title
Immunology
Volume: 130
Pages: 137-149
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[Journal Article] SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration2009
Author(s)
Yo, K., Iwata, S., Hashizume, Y., Kondo, S., Nomura, S., Hosono, O., Kawasaki, H., Tanaka, H., Dang, N. H., and Morimoto, C.
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Journal Title
Biochem Biophys Res Commun
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[Journal Article] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells2009
Author(s)
Nishida, H., Yamazaki, H., Yamada, T., Iwata, S., Dang, N. H., Inukai, T., Sugita, K., Ikeda, Y., and Morimoto, C.
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Journal Title
Biochem Biophys Res Commun.
Related Report
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[Journal Article] The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans2009
Author(s)
Hashimoto-Okada, M., Kitawaki, T., Kadowaki, N., Iwata, S., Morimoto, C., Hori, T., and Uchiyama, T.
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Journal Title
Int Immunol
Volume: 21
Pages: 891-904
NAID
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[Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-Induced Arthritis2011
Author(s)
Otsuki, N., Iwata, S., Kumagai, S., Yamada, T., Katayose, T., Kichikawa, Y., Hosono, O., Kawasaki, H., Tanaka, H., Dang, N. H., and Morimoto, C.
Organizer
2011 Annual Scientific Meeting of American College of Rheumatology
Place of Presentation
Chicago, Illinois
Year and Date
2011-11-07
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