The research of aspirin induced asthma associated with prostaglandin receptors

• Project/Area Number: 21591280
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Niigata University
• Principal Investigator: KOYA Toshiyuki 新潟大学, 医歯学系, 助教 (90444158)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Takashi 新潟大学, 医歯学総合病院, 准教授 (90361906)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 気管支喘息 / アスピリン喘息 / プロスタグランジン / 動物実験 / 気道過敏性 / プロスタグランジンI2 / トロンボキサン合成酵素阻害 / 肝細胞増殖因子 / 気道リモデリング / プロスタグランジンE2 / 好酸球性気道炎症

Research Abstract

Original plan was to analyse the role of the receptor of prostaglandin E2(EP)(kindly gifted from Ono pharmaceutical company) in murine model of asthma by using EP agonist, however, it found out that beraprost, the agonist of prostaglandin I2 receptor(IP) had potentials to suppress airway allergic inflammation more that EP agonists. Moreover, a novel IP agonist(kindly gifted from Ono pharmaceutical company) that has the inhibitory effects of thromboxane synthesis, induced significant suppression of airway hyperresponsiveness and airway eosinophilic inflammation in murine asthma mode. This mechanism appeared to be due to the alteration of lung dendritic cell functions.

Research Products

• [Journal Article] A Novel Prostacyclin Agonist Protects to Airway Hyperresponsiveness and Remodeling in Mice (2012)
  • Author(s): Yamabayashi C, Koya T, Kagamu H, Kawakami H, Kimura Y, Furukawa T, Sakagami T, Hasegawa T, Sakai Y, Matsumoto K, Nakayama M, Gelfand EW, Suzuki E, Narita I
  • Journal Title: Am J Respir Cell Mol Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] A Novel Prostacyclin Agonist Protects against Airway Hyperresponsiveness and Remodeling in Mice (2012)
  • Author(s): Yamabayashi C, Koya T, 総名11名
  • Journal Title: American Journal of Respiratory Cell and Molecular Biology Volume: (In press)
  • Peer Reviewed
• [Journal Article] A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice (2010)
  • Author(s): Hayashi M, Koya T, Kawakami H, Sakagami T, Hasegawa T, Kagamu H, Takada T, Sakai Y, Suzuki E, Gelfand EW, Gejyo F
  • Journal Title: Clin Exp Allergy Volume: 40 Pages: 317-26
  • Peer Reviewed
• [Journal Article] A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice. (2010)
  • Author(s): 林正周、小屋俊之、長谷川隆志, ら
  • Journal Title: Clinical Experimental Allergy 40 Pages: 317-26
  • Peer Reviewed
• [Presentation] A Sustained-Release Prostacyclin Agonist With Thromboxane Inhibitory Activity (ONO-1301MS) Improves Airway Inflammation And Remodeling In A Murine Model Of Chronic House Dust Mite-Induced Airway Disease (2012)
  • Author(s): Kimura Y, Koya T, ほか11名
  • Organizer: American Thoracic Society International Conference 2012
  • Place of Presentation: Moscone Center, San Francisco, USA
  • Year and Date: 2012-05-20
• [Presentation] A Sustained-Release Prostacyclin Agonist With Thromboxane Inhibitory Activity(ONO-1301MS) Improves Airway Inflammation And Remodeling In A Murine Model Of Chronic House Dust Mite-Induced Airway Disease (2012)
  • Author(s): Y. Kimura, T. Koya, H. Sakamoto, H. Kawakami, Y. Hoshino, T. Furukawa, T. Sakagami, T. Hasegawa, H. Kagamu, Y. Sakai, K. Matsumoto, E. Suzuki, I. Narita
  • Organizer: American Thoracic Society International Conference 2012
  • Place of Presentation: Moscone Center, San Francisco, USA
  • Year and Date: 2012-05-18
• [Presentation] ダニ誘発マウス喘息モデルにおけるONO-1301の喘息抑制効果の検討 (2011)
  • Author(s): 木村陽介,小屋俊之,河上英則,星野芳史,坂上拓郎,坂元宏隆,長谷川隆志,酒井芳紀,松本邦夫,鈴木栄一,成田一衛
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 品川高輪プリンスホテル(東京都)
  • Year and Date: 2011-11-30
• [Presentation] TX合成酵素阻害作用を併せ持つPGI2アゴニストのダニ誘発マウス喘息モデルにおける喘息抑制効果の検討 (2011)
  • Author(s): 木村陽介,小屋俊之,河上英則,星野芳史,坂上拓郎,坂元宏隆,長谷川隆志,酒井芳紀,松本邦夫,鈴木栄一,成田一衛
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-11-25
• [Presentation] ONO-1301(PGI2アゴニスト+TX合成酵素阻害)のマウス慢性喘息モデルにおける気道過敏性の抑制効果 (2010)
  • Author(s): 小屋俊之,河上英則,木村陽介,星野芳史,坂上拓郎,坂元宏隆,長谷川隆志,酒井芳紀,松本邦夫,中山瑞穂,鈴木栄一,成田一衛
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-26
• [Presentation] ONO-1301(PGI_2アゴニスト+TX合成酵素阻害)のマウス慢性喘息モデルにおける気道過敏性の抑制効果 (2010)
  • Author(s): 小屋俊之、長谷川隆志, ほか10名
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-26
• [Presentation] TX合成酵素阻害作用を併せ持つPGI2アゴニストのダニ誘発マウス喘息モデルにおける喘息抑制効果の検討 (2010)
  • Author(s): 木村陽介、小屋俊之, ほか7名
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-25