Effects of oral tolerance in allergen-induced airway responses
Project/Area Number |
21591281
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANEHIRO Arihiko 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (20243503)
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Research Collaborator |
ERWIN W gelfand National Jewish Health, Denver, CO, USA, Department of Pediatrics
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 気管支喘息 / 免疫寛容 / 気道過敏性 / 気道炎症 / アレルギー |
Research Abstract |
Oral administration of soluble antigen before immunization induces peripheral tolerance and is effective in suppressing animal models of autoimmune diseases. However, few studies have focused on effects on Th-2 type diseases. Mice were sensitized to ovalbumin(OVA) and subsequently challenged with OVA via the airways, eliciting airway hyperresponsiveness(AHR) and airway inflammation. The feeding effects of OVA at different phases of the immune response were evaluated. Mice exposed to both multiple high dose feeding and multiple low dose feeding before sensitization with OVA failed to develop AHR or airway inflammation. High dose feeding of OVA also abrogated AHR and partially suppressed airway inflammation when initiated after sensitization with OVA, but prior to challenge ; low dose feeding partially suppressed AHR but did not affect the development of airway inflammation. High dose but not low dose feeding was effective on AHR when initiated even after challenge with OVA. These data indicate that the dose and phase of the response may be critical in dictating the effect of inducing oral tolerance on allergen-induced AHR and airway inflammation
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Requirement for CCR5 in the development of allergen-induced airway hyperresponsiveness and inflammation2011
Author(s)
Fuchimoto Y, Kanehiro A, Miyahara N, Koga H, Ikeda G, Waseda K, Tanimoto Y, Ueha S, Kataoka M, Gelfand EW, Tanimoto M
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Journal Title
Am J Respir Cell MolBiol
Volume: 45(6)
Pages: 1248-55
Related Report
Peer Reviewed
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[Journal Article] Blocking the leukotriene B4 receptor 1 inhibits late phase airway responses in established disease2011
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Fuchimoto Y, Kurimoto E, Tanimoto Y, Kataoka M, Tanimoto M, Gelfand EW
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Journal Title
Am J Respir Cell Mol Biol
Volume: 45
Pages: 851-7
Related Report
Peer Reviewed
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[Journal Article] Requirement for CCR5 in the development of allergen-induced airway hyperresponsiveness and inflammation2011
Author(s)
Fuchimoto Y, Kanehiro A, Miyahara N, Koga H, Ikeda G, Waseda K, Tanimoto Y, Ueha S, Kataoka M, Gelfand EW, Tanimoto M
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Journal Title
Am J Respir Cell Mol Biol
Volume: 45
Pages: 1248-1255
Related Report
Peer Reviewed
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[Journal Article] Successful extracorporeal life support for life-threatening hypercapnia with bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation2011
Author(s)
Waseda K, Tanimoto Y, Ichiba S, Miyahara N, Murakami T, Ochi N, Terado M, Nagano O, Maeda Y, Kanehiro A, Ujike Y, Tanimoto M
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Journal Title
Acta Med Okayama
Volume: 65
Pages: 403-406
Related Report
Peer Reviewed
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[Journal Article] Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation2009
Author(s)
Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW
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Journal Title
J Immunol
Volume: 183
Pages: 181-90
Related Report
Peer Reviewed
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[Journal Article] Leukotriene B4 Release from Mast Cells in IgE-Mediated Airway Hyperresponsiveness and Inflammation2009
Author(s)
Miyahara N, Ohnishi H, Miyahara S, Takeda K, Matsubara S, Matsuda H, Okamoto M, Loader JE, Joetham A, Tanimoto M, Dakhama A, Gelfand EW
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Journal Title
Am J Respir Cell Mol Biol
Volume: 40
Pages: 672-82
Related Report
Peer Reviewed
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[Presentation] オキサリプラチンアレルギーを獲得した大腸癌患者に対する減感作によるオキサリプラチン再投与の検討2011
Author(s)
谷本安, 谷口暁彦, 能島大輔, 栗本悦子, 早稲田公一, 古賀光, 宮原信明, 木浦勝行, 宗田良, 片岡幹男, 谷本光音
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Year and Date
2011-11-11
Related Report
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[Presentation] オマリズマブ投与により著明な改善を認めた好酸球性副鼻腔炎合併難治性喘息の1例2011
Author(s)
谷口暁彦, 金廣有彦, 宮原信明, 能島大輔, 栗本悦子, 早稲田公一, 谷本安, 片岡幹男, 木浦勝行, 岡野光博, 谷本光音
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Year and Date
2011-11-11
Related Report
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[Presentation] Importance of receptor for advanced glycation end products(RAGE) to the development of elastase-induced pulmonary inflammation and emphysema in mice2011
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Kurimoto E, Fuchimoto E, Taniguchi A, Tanimoto Y, Kataoka M, Gelfand EW, Tanimoto M
Organizer
ATS International Conference
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-18
Related Report
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[Presentation] Importance of receptor for advanced glycation end products (RAGE) to the development of elastase-induced pulmonary inflammation and emphysema in mice2011
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Kurimoto E, Fuchimoto E, Taniguchi A, Tanimoto Y, Kataoka M, (Gelfand EW), Tanimoto M
Organizer
ATS International Conference
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-18
Related Report
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[Presentation] 吸入ステロイド治療を継続中の喘息患者の吸気流速と背景因子の関連性調査中国、四国地区多施設研究2011
Author(s)
尾長谷靖, 金廣有彦, 谷本安, 宮原信明, 谷本光音, 岡三喜男, 江田良輔, 窪田哲也, 横山彰仁, 若林規良, 竹山博泰, 岡田千春, 木村五郎, 宗田良, 高橋清
Organizer
第23回日本アレルギー学会春季臨床大会
Place of Presentation
千葉
Year and Date
2011-05-14
Related Report
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[Presentation] アレルギー性気道反応における経口免疫寛容の効果2010
Author(s)
宮原信明, 武田勝行, 宮原聡子, 早稲田公一, 栗本悦子, 池田元洋, 古賀光, 谷口暁彦, 能島大輔, 渊本康子, 谷本安, 金廣有彦, 片岡幹男, Gelfand EW, 谷本光音
Organizer
第60回日本アレルギー学会秋期学術大会
Place of Presentation
東京
Year and Date
2010-11-25
Related Report
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[Presentation] Blockade of the leukotriene B4 receptor 1 suppresses allergen-induced late phase airway development of AHR and inflammation in established asthma2010
Author(s)
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Fuchimoto Y, Koga H, Kurimoto E, Tanimoto Y, Kataoka M, Yanimoto M, Gelfand EW
Organizer
ATS International Conference
Place of Presentation
New Orleans, USA
Year and Date
2010-04-14
Related Report
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[Presentation] Effect of cysteiny leukotriene receptor antagonist on airway hyperresponsiveness, airway inhlammation, and the development of emphysematous change in a murine model of COPD combined with bronchial asthma2010
Author(s)
Ikeda G, Kanehiro A, Miyahara N, Koga H, Fuchimoto Y, Waseda K, Kurimoto E, Ono K, Hirano A, Tanimoto Y, Kataoka M, Tanimoto M
Organizer
ATS International Conference
Place of Presentation
New Orleans, USA
Year and Date
2010-04-14
Related Report
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