| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
It is suggested that Pendrin, which is an anion channel induced by IL-13, is important for the pathogenesis of bronchial asthma. In this study, we confirmed the involvement of Pendrin in the pathogenesis of bronchial asthma, and present a novel hypothesis that a thiocyanate ion transported by Pendrin to the airway surface is converted to a hypothiocyanous acid by heme-peroxidase enzymes, and then this acid affects airway epithelial cells and amplifies allergic airway inflammation through the activation of NF-kb and ERK.
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