The effect of low level of adiponectin on inflammation in vivo

• Project/Area Number: 21591288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Showa University
• Principal Investigator: NEGORO Takaharu 昭和大学, 薬学部, 講師 (70218270)
• Co-Investigator(Kenkyū-buntansha): NAKANO Yasuko 昭和大学, 薬学部, 教授 (20155790) ; SAITO Kiyomi 昭和大学, 薬学部, 助教 (70307065)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 炎症学 / アディポネクチン / 炎症 / マクロファージ / 酸応答性チャネル / 炎症性サイトカイン / adiponectin Tg mouse / カルシウム / B細胞 / adiponectin / 関節リウマチ / 抗炎症 / Th17 / 制御性T細胞 / 肥満 / adiponectin Tgマウス

Research Abstract

We analyzed two models for higher susceptibility to inflammatory stimuli under low level of adiponectin. One was an acid induced writhing model and the other was a rheumatoid arthritis(RA) model caused by the antibody of type 1 collagen. It's to be anticipated that the threshold of acid-sensing ion channels(ASICs) to acid stimuli was reduced and the expression of inflammatory cytokines was enhanced in macrophages under the condition. Moreover, the similar results go on being observed in RA model.

Research Products

• [Journal Article] Impaired Ca^<2+> regulation of CD^<4+> CD^<25+> regulatory T cells from pediatric asthma. (2011)
  • Author(s): Y. Yamamoto, T. Negoro, A. Hoshi, A. Wakagi, S. Shimizu, A. H. Banham, M. Ishii, H. Akiyama, Y. Kiuchi, S. Sunaga, T. Tobe, G. Roncador, K. Itabashi, and Y. Nakano
  • Journal Title: Int Arch Allergy Immunol Volume: 156 Pages: 148-158
• [Journal Article] Impaired Ca2+ regulation of CD4+CD25+ regulatory T cells from pediatric asthma (2011)
  • Author(s): Yamamoto Y
  • Journal Title: International Archives of Allergy and Immunology Volume: 156 Issue: 2 Pages: 148-158
  • DOI: 10.1159/000322845
  • Peer Reviewed
• [Journal Article] Participation of Th17 and Treg cells in pediatric bronchial asthma (2010)
  • Author(s): Y. Yamamoto, T. Negoro, A. Wakagi, A. Hoshi, A. H. Banham, Gi. Roncador, H. Akiyama, T. Tobe, S. Sunaga, Y. Nakano, and K. Itabashi
  • Journal Title: J. Health. Sci Volume: 56 Pages: 589-597
  • NAID: 130000425095
• [Journal Article] Participation of Th17 and Treg cells in pediatric bronchial asthma (2010)
  • Author(s): Yamamoto Y, Negoro T, et al.
  • Journal Title: Journal of Health Science Volume: 56 Pages: 589-597
  • NAID: 130000425095
  • Peer Reviewed
• [Presentation] Effect of RACK1 on impaired functions of CD4+CD25+ regulatory T cells from asthma subjects (2011)
  • Author(s): 根来孝治
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] Mechanisms of pathogenesis of diabetes induced by atypical antipsychotic drugs (2011)
  • Author(s): 秋山晴代
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] 非定型抗精神病薬の糖尿病病態発症機構の解明 (2010)
  • Author(s): 細野由佳
  • Organizer: BMB2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] 関節リウマチにおけるアディポネクチンの炎症病態への影響 (2010)
  • Author(s): 嶋田紘也
  • Organizer: 第60回 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] Effect of adiponectin on macrophage viae pH-sensor (2010)
  • Author(s): Negoro Takaharu
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-25
• [Presentation] The role of ectopically-expressed adiponectin in rheumatoid arthritis (2010)
  • Author(s): Akiyama Haruyo
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] 非定型抗精神病薬の脂肪細胞分化に及ぼす影響の検討 (2010)
  • Author(s): 秋山晴代
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] The role of ectopically-expressed adiponectin in rheumatoid arthritis (2010)
  • Author(s): Haruyo Akiyama, 他
  • Organizer: 14th ICI 2010 annual meeting
  • Place of Presentation: Kobe, Japan
• [Presentation] Effect of adiponectin on macrophage via the pH sensor (2010)
  • Author(s): Takaharu Negoro, 他
  • Organizer: 14th ICI 2010 annual meeting
  • Place of Presentation: Kobe, Japan
• [Presentation] 関節リウマチにおけるアディポネクチンの炎症病態への影響 (2010)
  • Author(s): 嶋田紘也他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] 転写因子FOXP3の機能調節メカニズムに関する解析 (2009)
  • Author(s): 池田佳奈子
  • Organizer: 第39回 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-03
• [Presentation] アディポネチンの抗炎症作用機序解析(続報) (2009)
  • Author(s): 詫間彰俊
  • Organizer: 第39回 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Presentation] 非定型抗精神病薬の脂肪細胞分化及びアディポネクチン分泌に及ぼす影響の検討 (2009)
  • Author(s): 秋山晴代
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-23
• [Presentation] LPSによる炎症誘導時のHMWアディポネクチンの機能 (2009)
  • Author(s): 嶋田紘也
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-23
• [Presentation] LPSによる炎症誘導時のHMWアディポネクチンの機能/The effect of HMW adiponectin in RAW264.7 under inflammation induced by LPS (2009)
  • Author(s): 嶋田紘也他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] アディポネチンの抗炎症作用機序解析(続報)/Influence of adiponectin on functions of macrophages(followup report) (2009)
  • Author(s): Akitoshi Takuma, 他
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Book] 範囲 血液・尿化学検査、免疫学的検査 -その数値をどう読むか-【第7版】 共同著 (2010)
  • Author(s): 根来孝治、中野泰子
  • Publisher: 日本臨床
• [Remarks]
  • URL: http://www.showa-u.ac.jp/sch/pharm/major/medinfo/index.html
• [Remarks]
  • URL: http://www.showa-u.ac.jp/sch/pharm/major/medinfo/index.html