| Project/Area Number |
21591289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
|
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| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
ITO Tomoki 関西医科大学, 医学部, 准教授 (70434826)
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| Co-Investigator(Kenkyū-buntansha) |
INABA Muneo 関西医科大学, 医学部, 非常勤講師 (70115947)
FUKUHARA Shirou 関西医科大学, 医学部, 教授 (40142301)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 臨床免疫学 / OX40リガンド / Dendritic cell / スタチン / アレルギー / TSLP / NF-kB p50 / 制御性T細胞 / 自己免疫疾患 / TGF-β / IL-17 / Th17 / IFN-α / IL-10 / IL-33 |
|---|
| Research Abstract |
We found that OX40L plays an important role in the allergic inflammation by which IL-33 mediates Th2 cell differentiation. Moreover, OX40L was found to inhibit the induction of FOXP3 and CTLA4 in the generation of regulatory T cells. We also found that statins have capacity to inhibit the DC-derived OX40L induction.
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