Mechanism of severity of emerging rickettsial infection, Japanese spotted fever.
| Project/Area Number |
21591292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Nobuhiro 福井大学, 医学部, シニアフェロー (90003409)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEGAYA Satoshi 福井大学, 医学部, 助教 (10324162)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 感染症治療学 / 新興リケッチア感染症 / 日本紅斑熱 / サイトカイン / リケッチア感染症 / 新興感染症 / テトラサイクリン / ニューキノロン / ケモカイン |
|---|
| Research Abstract |
Recently, emerging rickettsial infection, Japanese spotted fever(JSF : Rickettsia japonica infection) is becoming a major rickettsioses in Japan. Many severe patients are reported, however we don' t have an appropriate chemotherapy to recover from the severe state of this infectious disease. In this research we present an effective combined chemotherapy for JSF using tetracyclines and fluoroquinolons simultaneously. Many severe cases showed high concentration of TNF-αin the serum. In vitro assay, the TNF-αproduction was suppressed by tetracyclines, and this phenomenon was accelerated by a part of fluoroquinolons. This combined chemotherapy is a candidate for suitable treatment of JSF.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] 宮古島のつつが虫病患者発生地に生息するカニ寄生ツツガムシ2011
Author(s)
高橋守,三角仁子,亀田和成,藤田博己,角坂照貴,高田伸弘,平良勝也,山本正悟,安藤秀二,川端寛樹,北野智一,岡野洋,御供田睦代,高野愛,矢野泰弘,及川陽三郎,本田俊郎,岩崎博道,平良セツ子,岸本壽男
Organizer
第63回日本衛生動物学会大会
Place of Presentation
東京
Year and Date
2011-04-14
Related Report
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[Presentation] 第84回日本感染症学会総会2010
Author(s)
田居克規, 池ヶ谷諭史, 岩崎博道, 高木和貴, 浦崎芳正, 上田孝典
Organizer
抗菌薬によるサイトカイン産生修飾作用の網羅的解析
Place of Presentation
京都
Year and Date
2010-04-05
Related Report
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[Presentation] Significance of GPC bacteremia during the neutropenic status in hematological malignancies2009
Author(s)
Iwasaki H, Ikegaya S, Tai K, Hosono N, Negoro E, Takagi K, Kishi S, Yamauchi T, Yoshida A, Urasaki Y, Ueda T
Organizer
第71回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2009-10-24
Related Report
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