| Project/Area Number |
21591292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Nobuhiro 福井大学, 医学部, シニアフェロー (90003409)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEGAYA Satoshi 福井大学, 医学部, 助教 (10324162)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 感染症治療学 / 新興リケッチア感染症 / 日本紅斑熱 / サイトカイン / リケッチア感染症 / 新興感染症 / テトラサイクリン / ニューキノロン / ケモカイン |
|---|
| Research Abstract |
Recently, emerging rickettsial infection, Japanese spotted fever(JSF : Rickettsia japonica infection) is becoming a major rickettsioses in Japan. Many severe patients are reported, however we don' t have an appropriate chemotherapy to recover from the severe state of this infectious disease. In this research we present an effective combined chemotherapy for JSF using tetracyclines and fluoroquinolons simultaneously. Many severe cases showed high concentration of TNF-αin the serum. In vitro assay, the TNF-αproduction was suppressed by tetracyclines, and this phenomenon was accelerated by a part of fluoroquinolons. This combined chemotherapy is a candidate for suitable treatment of JSF.
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